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Manipulation of host cell death pathways during microbial infections

(2010) CELL HOST & MICROBE. 8(1). p.44-54
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Abstract
Viral and microbial infections often elicit programmed cell death as part of the host defense system or as a component of the survival strategy of the pathogen. It is thus not surprising that pathogens have evolved an array of toxins and virulence factors to modulate host cell death pathways. Apoptosis, necrosis, and pyroptosis constitute the three major cell death modes for elimination of infected cells. Herein, we discuss the signaling pathways underlying the principal host cell death mechanisms and provide an overview of the strategies employed by viral and microbial pathogens to manipulate these cell death processes.
Keywords
RECEPTOR-INTERACTING PROTEIN, FRANCISELLA-TULARENSIS, CYTOCHROME-C RELEASE, NECROSIS-FACTOR RECEPTOR-1, LYMPHOCYTE APOPTOSIS, CASPASE ACTIVATION, MACROPHAGE APOPTOSIS, PROGRAMMED NECROSIS, IMPROVES SURVIVAL, AIM2 INFLAMMASOME

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Citation

Please use this url to cite or link to this publication:

Chicago
Lamkanfi, Mohamed, and Vishva M Dixit. 2010. “Manipulation of Host Cell Death Pathways During Microbial Infections.” Cell Host & Microbe 8 (1): 44–54.
APA
Lamkanfi, M., & Dixit, V. M. (2010). Manipulation of host cell death pathways during microbial infections. CELL HOST & MICROBE, 8(1), 44–54.
Vancouver
1.
Lamkanfi M, Dixit VM. Manipulation of host cell death pathways during microbial infections. CELL HOST & MICROBE. 2010;8(1):44–54.
MLA
Lamkanfi, Mohamed, and Vishva M Dixit. “Manipulation of Host Cell Death Pathways During Microbial Infections.” CELL HOST & MICROBE 8.1 (2010): 44–54. Print.
@article{1023107,
  abstract     = {Viral and microbial infections often elicit programmed cell death as part of the host defense system or as a component of the survival strategy of the pathogen. It is thus not surprising that pathogens have evolved an array of toxins and virulence factors to modulate host cell death pathways. Apoptosis, necrosis, and pyroptosis constitute the three major cell death modes for elimination of infected cells. Herein, we discuss the signaling pathways underlying the principal host cell death mechanisms and provide an overview of the strategies employed by viral and microbial pathogens to manipulate these cell death processes.},
  author       = {Lamkanfi, Mohamed and Dixit, Vishva M},
  issn         = {1931-3128},
  journal      = {CELL HOST \& MICROBE},
  keyword      = {RECEPTOR-INTERACTING PROTEIN,FRANCISELLA-TULARENSIS,CYTOCHROME-C RELEASE,NECROSIS-FACTOR RECEPTOR-1,LYMPHOCYTE APOPTOSIS,CASPASE ACTIVATION,MACROPHAGE APOPTOSIS,PROGRAMMED NECROSIS,IMPROVES SURVIVAL,AIM2 INFLAMMASOME},
  language     = {eng},
  number       = {1},
  pages        = {44--54},
  title        = {Manipulation of host cell death pathways during microbial infections},
  url          = {http://dx.doi.org/10.1016/j.chom.2010.06.007},
  volume       = {8},
  year         = {2010},
}

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