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PEPE II: a multicenter study with an end-point heparin-bonded expanded polytetrafluoroethylene vascular graft for above and below knee bypass surgery: determinants of patency

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Organization
Abstract
Aim The Propaten European Product Evaluation (PEPE H) study was a product evaluation Intended to characterize the performance of the GORE PROPATEN(R) vascular graft in above-knee (AK) and below-knee bypass (BK) surgery. Methods. This prospective multicenter trial enrolled 142 patients with peripheral arterial disease. in 87 patients AK and in 52 patients BK bypasses (including 15 femorocrural) were implanted (67.6% males, 32.4% females). Results. The one-year overall primary and secondary patency rates were 80% and 84.7%, respectively. Overall limb salvage rate at 12-months was 96.2%. The primary patency rate for AK bypasses was 82.7%, for BK femoropopliteal bypasses 74.2% and for BK tibial-peroneal bypasses 79.4%. Secondary patency rates were 87.3%, 78.8% and 85.1%, respectively. Primary patency rates decreased depending on the number of patent run-off vessels (three 84.3%, two 80.8%, one 73.3%). Subgroup analysis showed that female patients had a significantly higher primary patency rate for BK bypasses (95.5% vs. 67.8%, P=0.037) compared to male patients. Subgroup analysis comparing patients younger and older than 70 years did not show a statistically significant difference in patency rates. Twenty-one patients underwent 42 reinterventions after bypass surgery. Conclusion. Present data show that the end-point heparin-bonded polytetrafluoroethylene graft yields patency rates comparable to those obtained with other graft material in above-knee locations. The encouraging results for BK bypasses suggests that this graft is an excellent option for small diameter vascular reconstructions when autologous vein is unavailable.
Keywords
Graft occlusion, vascular, Polytetra-fluoroethylene, Peripheral vascular diseases, FEMOROPOPLITEAL BYPASS, SAPHENOUS-VEIN, NEOINTIMAL HYPERPLASIA, PLATELET DEPOSITION, EPTFE GRAFTS, REVASCULARIZATION, TRIAL, ISCHEMIA, DISEASE, DACRON

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Citation

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Chicago
Hugl, B, A Nevelsteen, K Daenens, MA Perez, P Heider, M Railo, H Schelzig, et al. 2009. “PEPE II: a Multicenter Study with an End-point Heparin-bonded Expanded Polytetrafluoroethylene Vascular Graft for Above and Below Knee Bypass Surgery: Determinants of Patency.” Journal of Cardiovascular Surgery 50 (2): 195–203.
APA
Hugl, B., Nevelsteen, A., Daenens, K., Perez, M., Heider, P., Railo, M., Schelzig, H., et al. (2009). PEPE II: a multicenter study with an end-point heparin-bonded expanded polytetrafluoroethylene vascular graft for above and below knee bypass surgery: determinants of patency. JOURNAL OF CARDIOVASCULAR SURGERY, 50(2), 195–203.
Vancouver
1.
Hugl B, Nevelsteen A, Daenens K, Perez M, Heider P, Railo M, et al. PEPE II: a multicenter study with an end-point heparin-bonded expanded polytetrafluoroethylene vascular graft for above and below knee bypass surgery: determinants of patency. JOURNAL OF CARDIOVASCULAR SURGERY. 2009;50(2):195–203.
MLA
Hugl, B, A Nevelsteen, K Daenens, et al. “PEPE II: a Multicenter Study with an End-point Heparin-bonded Expanded Polytetrafluoroethylene Vascular Graft for Above and Below Knee Bypass Surgery: Determinants of Patency.” JOURNAL OF CARDIOVASCULAR SURGERY 50.2 (2009): 195–203. Print.
@article{1022635,
  abstract     = {Aim The Propaten European Product Evaluation (PEPE H) study was a product evaluation Intended to characterize the performance of the GORE PROPATEN(R) vascular graft in above-knee (AK) and below-knee bypass (BK) surgery.
Methods. This prospective multicenter trial enrolled 142 patients with peripheral arterial disease. in 87 patients AK and in 52 patients BK bypasses (including 15 femorocrural) were implanted (67.6\% males, 32.4\% females).
Results. The one-year overall primary and secondary patency rates were 80\% and 84.7\%, respectively. Overall limb salvage rate at 12-months was 96.2\%. The primary patency rate for AK bypasses was 82.7\%, for BK femoropopliteal bypasses 74.2\% and for BK tibial-peroneal bypasses 79.4\%. Secondary patency rates were 87.3\%, 78.8\% and 85.1\%, respectively. Primary patency rates decreased depending on the number of patent run-off vessels (three 84.3\%, two 80.8\%, one 73.3\%). Subgroup analysis showed that female patients had a significantly higher primary patency rate for BK bypasses (95.5\% vs. 67.8\%, P=0.037) compared to male patients. Subgroup analysis comparing patients younger and older than 70 years did not show a statistically significant difference in patency rates. Twenty-one patients underwent 42 reinterventions after bypass surgery.
Conclusion. Present data show that the end-point heparin-bonded polytetrafluoroethylene graft yields patency rates comparable to those obtained with other graft material in above-knee locations. The encouraging results for BK bypasses suggests that this graft is an excellent option for small diameter vascular reconstructions when autologous vein is unavailable.},
  author       = {Hugl, B and Nevelsteen, A and Daenens, K and Perez, MA and Heider, P and Railo, M and Schelzig, H and Gluecklich, B and Balzer, K and Vermassen, Frank and De Smit, P and Fraedrich, G},
  issn         = {0021-9509},
  journal      = {JOURNAL OF CARDIOVASCULAR SURGERY},
  keyword      = {Graft occlusion,vascular,Polytetra-fluoroethylene,Peripheral vascular diseases,FEMOROPOPLITEAL BYPASS,SAPHENOUS-VEIN,NEOINTIMAL HYPERPLASIA,PLATELET DEPOSITION,EPTFE GRAFTS,REVASCULARIZATION,TRIAL,ISCHEMIA,DISEASE,DACRON},
  language     = {eng},
  number       = {2},
  pages        = {195--203},
  title        = {PEPE II: a multicenter study with an end-point heparin-bonded expanded polytetrafluoroethylene vascular graft for above and below knee bypass surgery: determinants of patency},
  url          = {http://www.minervamedica.it/en/journals/cardiovascular-surgery/article.php?cod=R37Y2009N02A0195},
  volume       = {50},
  year         = {2009},
}

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