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Gravity is an important determinant of oxygenation during one-lung ventilation

Laszlo L Szegedi UGent, AA D'Hollander, Frank Vermassen UGent, Frederic De Ryck and Patrick Wouters UGent (2010) ACTA ANAESTHESIOLOGICA SCANDINAVICA. 54(6). p.744-750
abstract
Background : The role of gravity in the redistribution of pulmonary blood flow during one-lung ventilation (OLV) has been questioned recently. To address this controversial but clinically important issue, we used an experimental approach that allowed us to differentiate the effects of gravity from the effects of hypoxic pulmonary vasoconstriction (HPV) on arterial oxygenation during OLV in patients scheduled for thoracic surgery. Methods : Forty patients with chronic obstructive pulmonary disease scheduled for right lung tumour resection were randomized to undergo dependent (left) one-lung ventilation (D-OLV; n=20) or non-dependent (right) one-lung ventilation (ND-OLV; n=20) in the supine and left lateral positions. Partial pressure of arterial oxygen (PaO2) was measured as a surrogate for ventilation/perfusion matching. Patients were studied before surgery under closed chest conditions. Results : When compared with bilateral lung ventilation, both D-OLV and ND-OLV caused a significant and equal decrease in PaO2 in the supine position. However, D-OLV in the lateral position was associated with a higher PaO2 as compared with the supine position [274.2 (77.6) vs. 181.9 (68.3) mmHg, P < 0.01, analysis of variance (ANOVA)]. In contrast, in patients undergoing ND-OLV, PaO2 was always lower in the lateral as compared with the supine position [105.3 (63.2) vs. 187 (63.1) mmHg, P < 0.01, ANOVA]. Conclusion : The relative position of the ventilated vs. the non-ventilated lung markedly affects arterial oxygenation during OLV. These data suggest that gravity affects ventilation-perfusion matching independent of HPV.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
POSITION, PERFUSION, DOGS, SUPINE, MANAGEMENT
journal title
ACTA ANAESTHESIOLOGICA SCANDINAVICA
Acta Anaesthesiol. Scand.
volume
54
issue
6
pages
744 - 750
Web of Science type
Article
Web of Science id
000278292400012
JCR category
ANESTHESIOLOGY
JCR impact factor
2.196 (2010)
JCR rank
12/26 (2010)
JCR quartile
2 (2010)
ISSN
0001-5172
DOI
10.1111/j.1399-6576.2010.02238.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1022369
handle
http://hdl.handle.net/1854/LU-1022369
date created
2010-08-12 17:20:31
date last changed
2016-12-19 15:44:30
@article{1022369,
  abstract     = {Background : The role of gravity in the redistribution of pulmonary blood flow during one-lung ventilation (OLV) has been questioned recently. To address this controversial but clinically important issue, we used an experimental approach that allowed us to differentiate the effects of gravity from the effects of hypoxic pulmonary vasoconstriction (HPV) on arterial oxygenation during OLV in patients scheduled for thoracic surgery.
Methods : Forty patients with chronic obstructive pulmonary disease scheduled for right lung tumour resection were randomized to undergo dependent (left) one-lung ventilation (D-OLV; n=20) or non-dependent (right) one-lung ventilation (ND-OLV; n=20) in the supine and left lateral positions. Partial pressure of arterial oxygen (PaO2) was measured as a surrogate for ventilation/perfusion matching. Patients were studied before surgery under closed chest conditions.
Results : When compared with bilateral lung ventilation, both D-OLV and ND-OLV caused a significant and equal decrease in PaO2 in the supine position. However, D-OLV in the lateral position was associated with a higher PaO2 as compared with the supine position [274.2 (77.6) vs. 181.9 (68.3) mmHg, P {\textlangle} 0.01, analysis of variance (ANOVA)]. In contrast, in patients undergoing ND-OLV, PaO2 was always lower in the lateral as compared with the supine position [105.3 (63.2) vs. 187 (63.1) mmHg, P {\textlangle} 0.01, ANOVA].
Conclusion : The relative position of the ventilated vs. the non-ventilated lung markedly affects arterial oxygenation during OLV. These data suggest that gravity affects ventilation-perfusion matching independent of HPV.},
  author       = {Szegedi, Laszlo L and D'Hollander, AA and Vermassen, Frank and De Ryck, Frederic and Wouters, Patrick},
  issn         = {0001-5172},
  journal      = {ACTA ANAESTHESIOLOGICA SCANDINAVICA},
  keyword      = {POSITION,PERFUSION,DOGS,SUPINE,MANAGEMENT},
  language     = {eng},
  number       = {6},
  pages        = {744--750},
  title        = {Gravity is an important determinant of oxygenation during one-lung ventilation},
  url          = {http://dx.doi.org/10.1111/j.1399-6576.2010.02238.x},
  volume       = {54},
  year         = {2010},
}

Chicago
Szegedi, Laszlo L, AA D’Hollander, Frank Vermassen, FREDERIC DE RYCK, and Patrick Wouters. 2010. “Gravity Is an Important Determinant of Oxygenation During One-lung Ventilation.” Acta Anaesthesiologica Scandinavica 54 (6): 744–750.
APA
Szegedi, L. L., D’Hollander, A., Vermassen, F., DE RYCK, F., & Wouters, P. (2010). Gravity is an important determinant of oxygenation during one-lung ventilation. ACTA ANAESTHESIOLOGICA SCANDINAVICA, 54(6), 744–750.
Vancouver
1.
Szegedi LL, D’Hollander A, Vermassen F, DE RYCK F, Wouters P. Gravity is an important determinant of oxygenation during one-lung ventilation. ACTA ANAESTHESIOLOGICA SCANDINAVICA. 2010;54(6):744–50.
MLA
Szegedi, Laszlo L, AA D’Hollander, Frank Vermassen, et al. “Gravity Is an Important Determinant of Oxygenation During One-lung Ventilation.” ACTA ANAESTHESIOLOGICA SCANDINAVICA 54.6 (2010): 744–750. Print.