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Important role of muscle carnosine in rowing performance

Audrey Baguet UGent, Jan Bourgois UGent, Lander Vanhee UGent, Eric Achten UGent and Wim Derave UGent (2010) JOURNAL OF APPLIED PHYSIOLOGY. 109(4). p.1096-1101
abstract
The role of the presence of carnosine (beta-alanyl-L-histidine) in millimolar concentrations in human skeletal muscle is poorly understood. Chronic oral beta-alanine supplementation is shown to elevate muscle carnosine content and improve anaerobic exercise performance during some laboratory tests, mainly in the untrained. It remains to be determined whether carnosine loading can improve single competition-like events in elite athletes. The aims of the present study were to investigate if performance is related to the muscle carnosine content and if beta-alanine supplementation improves performance in highly-trained rowers. Eighteen Belgian elite rowers were supplemented for 7 weeks with either placebo or beta-alanine (5 g/day). Before and following supplementation, muscle carnosine content in soleus and gastrocnemius medialis was measured by proton magnetic resonance spectroscopy ((1)H-MRS) and the performance was evaluated in a 2000 m ergometer test. At baseline, there was a strong positive correlation between 100 m, 500 m, 2000 m and 6000 m speed and muscle carnosine content. After beta-alanine supplementation, the carnosine content increased by 45.3 % in soleus and 28.2 % in gastrocnemius. Following supplementation, the beta-alanine group was 4.3 s faster than the placebo group, whereas before supplementation they were 0.3 s slower (p=0.07). Muscle carnosine elevation was positively correlated to 2000 m performance enhancement (p=0.042 and r=0.498). It can be concluded that the positive correlation between baseline muscle carnosine levels and rowing performance and the positive correlation between changes in muscle carnosine and performance improvement suggest that muscle carnosine is a new determinant of rowing performance.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
muscle carnosine, Ergogenic supplements, exercise performance, rowing, beta-alanine, BETA-ALANINE SUPPLEMENTATION, HISTIDINE-CONTAINING DIPEPTIDES, CA-RELEASE CHANNELS, SKELETAL-MUSCLE, CREATINE SUPPLEMENTATION, ANSERINE, FATIGUE, ROWERS, INGESTION, ENDURANCE
journal title
JOURNAL OF APPLIED PHYSIOLOGY
J. Appl. Physiol.
volume
109
issue
4
pages
1096 - 1101
Web of Science type
Article
Web of Science id
000285344900021
JCR category
SPORT SCIENCES
JCR impact factor
4.232 (2010)
JCR rank
2/79 (2010)
JCR quartile
1 (2010)
ISSN
8750-7587
DOI
10.1152/japplphysiol.00141.2010
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1020627
handle
http://hdl.handle.net/1854/LU-1020627
date created
2010-08-11 11:36:22
date last changed
2015-06-17 09:10:15
@article{1020627,
  abstract     = {The role of the presence of carnosine (beta-alanyl-L-histidine) in millimolar concentrations in human skeletal muscle is poorly understood. Chronic oral beta-alanine supplementation is shown to elevate muscle carnosine content and improve anaerobic exercise performance during some laboratory tests, mainly in the untrained. It remains to be determined whether carnosine loading can improve single competition-like events in elite athletes. The aims of the present study were to investigate if performance is related to the muscle carnosine content and if beta-alanine supplementation improves performance in highly-trained rowers. Eighteen Belgian elite rowers were supplemented for 7 weeks with either placebo or beta-alanine (5 g/day). Before and following supplementation, muscle carnosine content in soleus and gastrocnemius medialis was measured by proton magnetic resonance spectroscopy ((1)H-MRS) and the performance was evaluated in a 2000 m ergometer test. At baseline, there was a strong positive correlation between 100 m, 500 m, 2000 m and 6000 m speed and muscle carnosine content. After beta-alanine supplementation, the carnosine content increased by 45.3 \% in soleus and 28.2 \% in gastrocnemius. Following supplementation, the beta-alanine group was 4.3 s faster than the placebo group, whereas before supplementation they were 0.3 s slower (p=0.07). Muscle carnosine elevation was positively correlated to 2000 m performance enhancement (p=0.042 and r=0.498). It can be concluded that the positive correlation between baseline muscle carnosine levels and rowing performance and the positive correlation between changes in muscle carnosine and performance improvement suggest that muscle carnosine is a new determinant of rowing performance.},
  author       = {Baguet, Audrey and Bourgois, Jan and Vanhee, Lander and Achten, Eric and Derave, Wim},
  issn         = {8750-7587},
  journal      = {JOURNAL OF APPLIED PHYSIOLOGY},
  keyword      = {muscle carnosine,Ergogenic supplements,exercise performance,rowing,beta-alanine,BETA-ALANINE SUPPLEMENTATION,HISTIDINE-CONTAINING DIPEPTIDES,CA-RELEASE CHANNELS,SKELETAL-MUSCLE,CREATINE SUPPLEMENTATION,ANSERINE,FATIGUE,ROWERS,INGESTION,ENDURANCE},
  language     = {eng},
  number       = {4},
  pages        = {1096--1101},
  title        = {Important role of muscle carnosine in rowing performance},
  url          = {http://dx.doi.org/10.1152/japplphysiol.00141.2010},
  volume       = {109},
  year         = {2010},
}

Chicago
Baguet, Audrey, Jan Bourgois, Lander Vanhee, Eric Achten, and Wim Derave. 2010. “Important Role of Muscle Carnosine in Rowing Performance.” Journal of Applied Physiology 109 (4): 1096–1101.
APA
Baguet, A., Bourgois, J., Vanhee, L., Achten, E., & Derave, W. (2010). Important role of muscle carnosine in rowing performance. JOURNAL OF APPLIED PHYSIOLOGY, 109(4), 1096–1101.
Vancouver
1.
Baguet A, Bourgois J, Vanhee L, Achten E, Derave W. Important role of muscle carnosine in rowing performance. JOURNAL OF APPLIED PHYSIOLOGY. 2010;109(4):1096–101.
MLA
Baguet, Audrey, Jan Bourgois, Lander Vanhee, et al. “Important Role of Muscle Carnosine in Rowing Performance.” JOURNAL OF APPLIED PHYSIOLOGY 109.4 (2010): 1096–1101. Print.