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The dopamine D4 receptor: biochemical and signalling properties

Pieter Rondou UGent, Guy Haegeman UGent and Kathleen Van Craenenbroeck UGent (2010) CELLULAR AND MOLECULAR LIFE SCIENCES. 67(12). p.1971-1986
abstract
Dopamine is an important neurotransmitter that regulates several key functions in the brain, such as motor output, motivation and reward, learning and memory, and endocrine regulation. Dopamine does not mediate fast synaptic transmission, but rather modulates it by triggering slow-acting effects through the activation of dopamine receptors, which belong to the G-protein-coupled receptor superfamily. Besides activating different effectors through G-protein coupling, dopamine receptors also signal through interaction with a variety of proteins, collectively termed dopamine receptor-interacting proteins. We focus on the dopamine D4 receptor, which contains an important polymorphism in its third intracellular loop. This polymorphism has been the subject of numerous studies investigating links with several brain disorders, such as attention-deficit hyperactivity disorder and schizophrenia. We provide an overview of the structure, signalling properties and regulation of dopamine D4 receptors, and briefly discuss their physiological and pathophysiological role in the brain.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
GPCR, PHARMACOLOGICAL CHARACTERIZATION, Dopamine, D4 receptor, Variable number of tandem repeats (VNTR), Dimerization, Internalization, Dopamine receptor-interacting protein (DRIP), Attention-deficit hyperactivity disorder (ADHD), DEFICIT HYPERACTIVITY DISORDER, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, PROTEIN-COUPLED RECEPTOR, HAMSTER OVARY CELLS, CONSERVED SERINE RESIDUES, D-4 RECEPTOR, PREFRONTAL CORTEX, DRD4 GENE, HIGH-AFFINITY
journal title
CELLULAR AND MOLECULAR LIFE SCIENCES
Cell. Mol. Life Sci.
volume
67
issue
12
pages
1971 - 1986
Web of Science type
Review
Web of Science id
000278111400002
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
7.047 (2010)
JCR rank
35/284 (2010)
JCR quartile
1 (2010)
ISSN
1420-682X
DOI
10.1007/s00018-010-0293-y
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1020576
handle
http://hdl.handle.net/1854/LU-1020576
date created
2010-08-11 10:11:44
date last changed
2010-08-19 09:30:46
@article{1020576,
  abstract     = {Dopamine is an important neurotransmitter that regulates several key functions in the brain, such as motor output, motivation and reward, learning and memory, and endocrine regulation. Dopamine does not mediate fast synaptic transmission, but rather modulates it by triggering slow-acting effects through the activation of dopamine receptors, which belong to the G-protein-coupled receptor superfamily. Besides activating different effectors through G-protein coupling, dopamine receptors also signal through interaction with a variety of proteins, collectively termed dopamine receptor-interacting proteins. We focus on the dopamine D4 receptor, which contains an important polymorphism in its third intracellular loop. This polymorphism has been the subject of numerous studies investigating links with several brain disorders, such as attention-deficit hyperactivity disorder and schizophrenia. We provide an overview of the structure, signalling properties and regulation of dopamine D4 receptors, and briefly discuss their physiological and pathophysiological role in the brain.},
  author       = {Rondou, Pieter and Haegeman, Guy and Van Craenenbroeck, Kathleen},
  issn         = {1420-682X},
  journal      = {CELLULAR AND MOLECULAR LIFE SCIENCES},
  keyword      = {GPCR,PHARMACOLOGICAL CHARACTERIZATION,Dopamine,D4 receptor,Variable number of tandem repeats (VNTR),Dimerization,Internalization,Dopamine receptor-interacting protein (DRIP),Attention-deficit hyperactivity disorder (ADHD),DEFICIT HYPERACTIVITY DISORDER,ATTENTION-DEFICIT/HYPERACTIVITY DISORDER,PROTEIN-COUPLED RECEPTOR,HAMSTER OVARY CELLS,CONSERVED SERINE RESIDUES,D-4 RECEPTOR,PREFRONTAL CORTEX,DRD4 GENE,HIGH-AFFINITY},
  language     = {eng},
  number       = {12},
  pages        = {1971--1986},
  title        = {The dopamine D4 receptor: biochemical and signalling properties},
  url          = {http://dx.doi.org/10.1007/s00018-010-0293-y},
  volume       = {67},
  year         = {2010},
}

Chicago
Rondou, Pieter, Guy Haegeman, and Kathleen Van Craenenbroeck. 2010. “The Dopamine D4 Receptor: Biochemical and Signalling Properties.” Cellular and Molecular Life Sciences 67 (12): 1971–1986.
APA
Rondou, P., Haegeman, G., & Van Craenenbroeck, K. (2010). The dopamine D4 receptor: biochemical and signalling properties. CELLULAR AND MOLECULAR LIFE SCIENCES, 67(12), 1971–1986.
Vancouver
1.
Rondou P, Haegeman G, Van Craenenbroeck K. The dopamine D4 receptor: biochemical and signalling properties. CELLULAR AND MOLECULAR LIFE SCIENCES. 2010;67(12):1971–86.
MLA
Rondou, Pieter, Guy Haegeman, and Kathleen Van Craenenbroeck. “The Dopamine D4 Receptor: Biochemical and Signalling Properties.” CELLULAR AND MOLECULAR LIFE SCIENCES 67.12 (2010): 1971–1986. Print.