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The X chromosome in immune functions: when a chromosome makes the difference

Claude Libert UGent, Lien Dejager and Iris Pinheiro UGent (2010) NATURE REVIEWS IMMUNOLOGY. 10(8). p.594-604
abstract
In response to various immune challenges, females show better survival than males; the X chromosome has an important role in this immunological advantage. X chromosome-linked diseases are usually restricted to males, who have only one copy of the X chromosome; however, females are more prone to autoimmune diseases, and the X chromosome may be involved in the breakdown of self tolerance. Several hypotheses have been proposed in recent years that support a role for the X chromosome in shaping autoimmune responses. Here, we review the main mechanisms responsible for increased immune activity in females. This provides a survival advantage in the face of pathogenic insult but can also enhance the susceptibility of females to autoimmunity.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
SYSTEMIC-LUPUS-ERYTHEMATOSUS, B ESSENTIAL MODULATOR, SUDDEN UNEXPECTED DEATH, AUTOIMMUNE-DISEASES, FEMALE PREDISPOSITION, TURNERS-SYNDROME, SEX-CHROMOSOMES, IMMUNODEFICIENCY DISEASES, MATRIX-METALLOPROTEINASES, DOSAGE COMPENSATION
journal title
NATURE REVIEWS IMMUNOLOGY
Nat. Rev. Immunol.
volume
10
issue
8
pages
594 - 604
Web of Science type
Review
Web of Science id
000280198400013
JCR category
IMMUNOLOGY
JCR impact factor
35.196 (2010)
JCR rank
2/133 (2010)
JCR quartile
1 (2010)
ISSN
1474-1733
DOI
10.1038/nri2815
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1019453
handle
http://hdl.handle.net/1854/LU-1019453
date created
2010-08-09 12:20:18
date last changed
2016-12-19 15:44:13
@article{1019453,
  abstract     = {In response to various immune challenges, females show better survival than males; the X chromosome has an important role in this immunological advantage. X chromosome-linked diseases are usually restricted to males, who have only one copy of the X chromosome; however, females are more prone to autoimmune diseases, and the X chromosome may be involved in the breakdown of self tolerance. Several hypotheses have been proposed in recent years that support a role for the X chromosome in shaping autoimmune responses. Here, we review the main mechanisms responsible for increased immune activity in females. This provides a survival advantage in the face of pathogenic insult but can also enhance the susceptibility of females to autoimmunity.},
  author       = {Libert, Claude and Dejager, Lien and Pinheiro, Iris},
  issn         = {1474-1733},
  journal      = {NATURE REVIEWS IMMUNOLOGY},
  keyword      = {SYSTEMIC-LUPUS-ERYTHEMATOSUS,B ESSENTIAL MODULATOR,SUDDEN UNEXPECTED DEATH,AUTOIMMUNE-DISEASES,FEMALE PREDISPOSITION,TURNERS-SYNDROME,SEX-CHROMOSOMES,IMMUNODEFICIENCY DISEASES,MATRIX-METALLOPROTEINASES,DOSAGE COMPENSATION},
  language     = {eng},
  number       = {8},
  pages        = {594--604},
  title        = {The X chromosome in immune functions: when a chromosome makes the difference},
  url          = {http://dx.doi.org/10.1038/nri2815},
  volume       = {10},
  year         = {2010},
}

Chicago
Libert, Claude, Lien Dejager, and Iris Pinheiro. 2010. “The X Chromosome in Immune Functions: When a Chromosome Makes the Difference.” Nature Reviews Immunology 10 (8): 594–604.
APA
Libert, C., Dejager, L., & Pinheiro, I. (2010). The X chromosome in immune functions: when a chromosome makes the difference. NATURE REVIEWS IMMUNOLOGY, 10(8), 594–604.
Vancouver
1.
Libert C, Dejager L, Pinheiro I. The X chromosome in immune functions: when a chromosome makes the difference. NATURE REVIEWS IMMUNOLOGY. 2010;10(8):594–604.
MLA
Libert, Claude, Lien Dejager, and Iris Pinheiro. “The X Chromosome in Immune Functions: When a Chromosome Makes the Difference.” NATURE REVIEWS IMMUNOLOGY 10.8 (2010): 594–604. Print.