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Effect of N,N-dimethylglycine supplementation in parturition feed for sows on metabolism, nutrient digestibility and reproductive performance

An Cools UGent, Dominiek Maes UGent, Johan Buyse, Isabelle Kalmar UGent, Jo-Ann Vandermeiren UGent and Geert Janssens UGent (2010) ANIMAL. 4(12). p.2004-2011
abstract
The current pilot study assessed the influence of N,N-dimethylglycine (DMG) on insulin sensitivity, glucose and fat metabolism, nutrient digestibility and reproductive performance of sows in the peripartal period. At day 105 of gestation, 25 sows were randomly assigned to the control (n = 13) or the DMG group (n = 12). Sows from the DMG group were supplemented with 1 g DMG/kg feed until day 3 of lactation. After an overnight fast 1 day after farrowing, a blood sample of each sow was drawn. The plasma was analyzed for insulin, glucose, fructosamine, leptin, thiobarbituric acid reactive substances (TBARS), ferric reducing ability of plasma (FRAP), non-esterified fatty acids (NEFA) and triglycerides (TG) and an oral glucose tolerance test was performed. A rectal feces sample was collected and the apparent fecal digestibility (AFD) of crude fat (CFAT), crude protein (CP) and nitrogen-free extract (NFE) was calculated after proximate analyses. Finally, a colostrum sample was collected from each sow and analyzed for the presence of DMG. Reproductive performance parameters were recorded. The results showed an improvement in the AFD of CFAT, CP and NFE when DMG was supplemented. This beneficial effect confirms the hypothesis that DMG acts as an emulsifying agent. The improvement in digestibility in the DMG group was accompanied by a numerical increase in plasma TG (P = 0.067). Plasma NEFA concentrations were not different between treatment groups. DMG supplementation neither affected glucose clearance nor influenced plasma insulin, glucose, fructosamine or leptin levels. TBARS and FRAP also remained unaffected, despite previously reported anti-oxidative properties of DMG. Furthermore, no significant impact on reproductive performance could be recorded. In conclusion, DMG supplementation significantly improved nutrient digestibility. Possible beneficial effects on energy metabolism and reproductive performance of sows should be tested when DMG is supplemented for a longer period of time or at a higher dose.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
in press
subject
keyword
N_N-dimethylglycine, nutrient digestibility, sow, glucose metabolism, reproduction, GLUCOSE-TOLERANCE, PRIMIPAROUS SOWS, POSTPARTUM HYPOPHAGIA, INSULIN-RESISTANCE, ENERGY-METABOLISM, MULTIPAROUS SOWS, LACTATION, PLASMA, BETAINE, FAT
journal title
ANIMAL
Animal
volume
4
issue
12
pages
2004 - 2011
Web of Science type
Article
Web of Science id
000283996800008
JCR category
VETERINARY SCIENCES
JCR impact factor
1.458 (2010)
JCR rank
32/145 (2010)
JCR quartile
1 (2010)
ISSN
1751-7311
DOI
10.1017/S1751731110001242
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1018691
handle
http://hdl.handle.net/1854/LU-1018691
date created
2010-08-06 11:56:53
date last changed
2011-07-07 14:17:49
@article{1018691,
  abstract     = {The current pilot study assessed the influence of N,N-dimethylglycine (DMG) on insulin sensitivity, glucose and fat metabolism, nutrient digestibility and reproductive performance of sows in the peripartal period. At day 105 of gestation, 25 sows were randomly assigned to the control (n = 13) or the DMG group (n = 12). Sows from the DMG group were supplemented with 1 g DMG/kg feed until day 3 of lactation. After an overnight fast 1 day after farrowing, a blood sample of each sow was drawn. The plasma was analyzed for insulin, glucose, fructosamine, leptin, thiobarbituric acid reactive substances (TBARS), ferric reducing ability of plasma (FRAP), non-esterified fatty acids (NEFA) and triglycerides (TG) and an oral glucose tolerance test was performed. A rectal feces sample was collected and the apparent fecal digestibility (AFD) of crude fat (CFAT), crude protein (CP) and nitrogen-free extract (NFE) was calculated after proximate analyses. Finally, a colostrum sample was collected from each sow and analyzed for the presence of DMG. Reproductive performance parameters were recorded. The results showed an improvement in the AFD of CFAT, CP and NFE when DMG was supplemented. This beneficial effect confirms the hypothesis that DMG acts as an emulsifying agent. The improvement in digestibility in the DMG group was accompanied by a numerical increase in plasma TG (P = 0.067). Plasma NEFA concentrations were not different between treatment groups. DMG supplementation neither affected glucose clearance nor influenced plasma insulin, glucose, fructosamine or leptin levels. TBARS and FRAP also remained unaffected, despite previously reported anti-oxidative properties of DMG. Furthermore, no significant impact on reproductive performance could be recorded. In conclusion, DMG supplementation significantly improved nutrient digestibility. Possible beneficial effects on energy metabolism and reproductive performance of sows should be tested when DMG is supplemented for a longer period of time or at a higher dose.},
  author       = {Cools, An and Maes, Dominiek and Buyse, Johan and Kalmar, Isabelle and Vandermeiren, Jo-Ann and Janssens, Geert},
  issn         = {1751-7311},
  journal      = {ANIMAL},
  keyword      = {N\_N-dimethylglycine,nutrient digestibility,sow,glucose metabolism,reproduction,GLUCOSE-TOLERANCE,PRIMIPAROUS SOWS,POSTPARTUM HYPOPHAGIA,INSULIN-RESISTANCE,ENERGY-METABOLISM,MULTIPAROUS SOWS,LACTATION,PLASMA,BETAINE,FAT},
  language     = {eng},
  number       = {12},
  pages        = {2004--2011},
  title        = {Effect of N,N-dimethylglycine supplementation in parturition feed for sows on metabolism, nutrient digestibility and reproductive performance},
  url          = {http://dx.doi.org/10.1017/S1751731110001242},
  volume       = {4},
  year         = {2010},
}

Chicago
Cools, An, Dominiek Maes, Johan Buyse, Isabelle Kalmar, Jo-Ann Vandermeiren, and Geert Janssens. 2010. “Effect of N,N-dimethylglycine Supplementation in Parturition Feed for Sows on Metabolism, Nutrient Digestibility and Reproductive Performance.” Animal 4 (12): 2004–2011.
APA
Cools, An, Maes, D., Buyse, J., Kalmar, I., Vandermeiren, J.-A., & Janssens, G. (2010). Effect of N,N-dimethylglycine supplementation in parturition feed for sows on metabolism, nutrient digestibility and reproductive performance. ANIMAL, 4(12), 2004–2011.
Vancouver
1.
Cools A, Maes D, Buyse J, Kalmar I, Vandermeiren J-A, Janssens G. Effect of N,N-dimethylglycine supplementation in parturition feed for sows on metabolism, nutrient digestibility and reproductive performance. ANIMAL. 2010;4(12):2004–11.
MLA
Cools, An, Dominiek Maes, Johan Buyse, et al. “Effect of N,N-dimethylglycine Supplementation in Parturition Feed for Sows on Metabolism, Nutrient Digestibility and Reproductive Performance.” ANIMAL 4.12 (2010): 2004–2011. Print.