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Auxin regulates distal stem cell differentiation in Arabidopsis roots

Zhaojun Ding (UGent) and Jiri Friml (UGent)
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Abstract
The stem cell niche in the root meristem is critical for the development of the plant root system. The plant hormone auxin acts as a versatile trigger in many developmental processes, including the regulation of root growth, but its role in the control of the stem cell activity remains largely unclear. Here we show that local auxin levels, determined by biosynthesis and intercellular transport, mediate maintenance or differentiation of distal stem cells in the Arabidopsis thaliana roots. Genetic analysis shows that auxin acts upstream of the major regulators of the stem cell activity, the homeodomain transcription factor WOX5, and the AP-2 transcription factor PLETHORA. Auxin signaling for differentiation of distal stem cells requires the transcriptional repressor IAA17/AXR3 as well as the ARF10 and ARF16 auxin response factors. ARF10 and ARF16 activities repress the WOX5 transcription and restrict it to the quiescent center, where WOX5, in turn, is needed for the activity of PLETHORA. Our investigations reveal that long-distance auxin signals act upstream of the short-range network of transcriptional factors to mediate the differentiation of distal stem cells in roots.
Keywords
EXPRESSION, NICHE, THALIANA, DIVISION, REGENERATION, columella differentiation, auxin, root, Arabidopsis

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Citation

Please use this url to cite or link to this publication:

Chicago
Ding, Zhaojun, and Jiri Friml. 2010. “Auxin Regulates Distal Stem Cell Differentiation in Arabidopsis Roots.” Proceedings of the National Academy of Sciences of the United States of America 107 (26): 12046–12051.
APA
Ding, Z., & Friml, J. (2010). Auxin regulates distal stem cell differentiation in Arabidopsis roots. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(26), 12046–12051.
Vancouver
1.
Ding Z, Friml J. Auxin regulates distal stem cell differentiation in Arabidopsis roots. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(26):12046–51.
MLA
Ding, Zhaojun, and Jiri Friml. “Auxin Regulates Distal Stem Cell Differentiation in Arabidopsis Roots.” PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107.26 (2010): 12046–12051. Print.
@article{1018431,
  abstract     = {The stem cell niche in the root meristem is critical for the development of the plant root system. The plant hormone auxin acts as a versatile trigger in many developmental processes, including the regulation of root growth, but its role in the control of the stem cell activity remains largely unclear. Here we show that local auxin levels, determined by biosynthesis and intercellular transport, mediate maintenance or differentiation of distal stem cells in the Arabidopsis thaliana roots. Genetic analysis shows that auxin acts upstream of the major regulators of the stem cell activity, the homeodomain transcription factor WOX5, and the AP-2 transcription factor PLETHORA. Auxin signaling for differentiation of distal stem cells requires the transcriptional repressor IAA17/AXR3 as well as the ARF10 and ARF16 auxin response factors. ARF10 and ARF16 activities repress the WOX5 transcription and restrict it to the quiescent center, where WOX5, in turn, is needed for the activity of PLETHORA. Our investigations reveal that long-distance auxin signals act upstream of the short-range network of transcriptional factors to mediate the differentiation of distal stem cells in roots.},
  author       = {Ding, Zhaojun and Friml, Jiri},
  issn         = {0027-8424},
  journal      = {PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA},
  keyword      = {EXPRESSION,NICHE,THALIANA,DIVISION,REGENERATION,columella differentiation,auxin,root,Arabidopsis},
  language     = {eng},
  number       = {26},
  pages        = {12046--12051},
  title        = {Auxin regulates distal stem cell differentiation in Arabidopsis roots},
  url          = {http://dx.doi.org/10.1073/pnas.1000672107},
  volume       = {107},
  year         = {2010},
}

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