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Prohibitins: mitochondrial partners in development and stress response

(2010) TRENDS IN PLANT SCIENCE. 15(5). p.275-282
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Abstract
Twelve years after their discovery in plants, prohibitins (PHBs) have retained their status as some of the most enigmatic mitochondrial proteins. Although the original hypothesis that PHBs act as negative cell cycle regulators has lost its impetus in plants, the essential molecular function(s) PHB complexes perform in the inner mitochondrial membrane are now beginning to be understood. We review the current state of knowledge to propose a unifying model that positions the PHB complex as a universal protein scaffold for key mitochondrial processes, including protein processing, respiratory chain function and mitochondrial DNA organization. Furthermore, recent findings indicate that PHBs play an active role in stress tolerance and are involved in triggering retrograde signals in response to stress and mitochondrial dysfunction.
Keywords
TRANSCRIPTION, PROTEINS, SPFH DOMAIN, CELL-PROLIFERATION, ALTERNATIVE OXIDASE, SACCHAROMYCES-CEREVISIAE, GENE-EXPRESSION, ARABIDOPSIS-THALIANA, M-AAA PROTEASE, REPLICATIVE LIFE-SPAN

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Citation

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Chicago
Van Aken, Olivier, James Whelan, and Frank Van Breusegem. 2010. “Prohibitins: Mitochondrial Partners in Development and Stress Response.” Trends in Plant Science 15 (5): 275–282.
APA
Van Aken, O., Whelan, J., & Van Breusegem, F. (2010). Prohibitins: mitochondrial partners in development and stress response. TRENDS IN PLANT SCIENCE, 15(5), 275–282.
Vancouver
1.
Van Aken O, Whelan J, Van Breusegem F. Prohibitins: mitochondrial partners in development and stress response. TRENDS IN PLANT SCIENCE. 2010;15(5):275–82.
MLA
Van Aken, Olivier, James Whelan, and Frank Van Breusegem. “Prohibitins: Mitochondrial Partners in Development and Stress Response.” TRENDS IN PLANT SCIENCE 15.5 (2010): 275–282. Print.
@article{1008281,
  abstract     = {Twelve years after their discovery in plants, prohibitins (PHBs) have retained their status as some of the most enigmatic mitochondrial proteins. Although the original hypothesis that PHBs act as negative cell cycle regulators has lost its impetus in plants, the essential molecular function(s) PHB complexes perform in the inner mitochondrial membrane are now beginning to be understood. We review the current state of knowledge to propose a unifying model that positions the PHB complex as a universal protein scaffold for key mitochondrial processes, including protein processing, respiratory chain function and mitochondrial DNA organization. Furthermore, recent findings indicate that PHBs play an active role in stress tolerance and are involved in triggering retrograde signals in response to stress and mitochondrial dysfunction.},
  author       = {Van Aken, Olivier and Whelan, James and Van Breusegem, Frank},
  issn         = {1360-1385},
  journal      = {TRENDS IN PLANT SCIENCE},
  keyword      = {TRANSCRIPTION,PROTEINS,SPFH DOMAIN,CELL-PROLIFERATION,ALTERNATIVE OXIDASE,SACCHAROMYCES-CEREVISIAE,GENE-EXPRESSION,ARABIDOPSIS-THALIANA,M-AAA PROTEASE,REPLICATIVE LIFE-SPAN},
  language     = {eng},
  number       = {5},
  pages        = {275--282},
  title        = {Prohibitins: mitochondrial partners in development and stress response},
  url          = {http://dx.doi.org/10.1016/j.tplants.2010.02.002},
  volume       = {15},
  year         = {2010},
}

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