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Prohibitins: mitochondrial partners in development and stress response

Olivier Van Aken, James Whelan and Frank Van Breusegem UGent (2010) TRENDS IN PLANT SCIENCE. 15(5). p.275-282
abstract
Twelve years after their discovery in plants, prohibitins (PHBs) have retained their status as some of the most enigmatic mitochondrial proteins. Although the original hypothesis that PHBs act as negative cell cycle regulators has lost its impetus in plants, the essential molecular function(s) PHB complexes perform in the inner mitochondrial membrane are now beginning to be understood. We review the current state of knowledge to propose a unifying model that positions the PHB complex as a universal protein scaffold for key mitochondrial processes, including protein processing, respiratory chain function and mitochondrial DNA organization. Furthermore, recent findings indicate that PHBs play an active role in stress tolerance and are involved in triggering retrograde signals in response to stress and mitochondrial dysfunction.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
TRANSCRIPTION, PROTEINS, SPFH DOMAIN, CELL-PROLIFERATION, ALTERNATIVE OXIDASE, SACCHAROMYCES-CEREVISIAE, GENE-EXPRESSION, ARABIDOPSIS-THALIANA, M-AAA PROTEASE, REPLICATIVE LIFE-SPAN
journal title
TRENDS IN PLANT SCIENCE
Trends Plant Sci.
volume
15
issue
5
pages
275 - 282
Web of Science type
Review
Web of Science id
000278197500005
JCR category
PLANT SCIENCES
JCR impact factor
10.095 (2010)
JCR rank
3/185 (2010)
JCR quartile
1 (2010)
ISSN
1360-1385
DOI
10.1016/j.tplants.2010.02.002
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1008281
handle
http://hdl.handle.net/1854/LU-1008281
date created
2010-07-09 17:45:54
date last changed
2012-09-19 14:04:01
@article{1008281,
  abstract     = {Twelve years after their discovery in plants, prohibitins (PHBs) have retained their status as some of the most enigmatic mitochondrial proteins. Although the original hypothesis that PHBs act as negative cell cycle regulators has lost its impetus in plants, the essential molecular function(s) PHB complexes perform in the inner mitochondrial membrane are now beginning to be understood. We review the current state of knowledge to propose a unifying model that positions the PHB complex as a universal protein scaffold for key mitochondrial processes, including protein processing, respiratory chain function and mitochondrial DNA organization. Furthermore, recent findings indicate that PHBs play an active role in stress tolerance and are involved in triggering retrograde signals in response to stress and mitochondrial dysfunction.},
  author       = {Van Aken, Olivier and Whelan, James and Van Breusegem, Frank},
  issn         = {1360-1385},
  journal      = {TRENDS IN PLANT SCIENCE},
  keyword      = {TRANSCRIPTION,PROTEINS,SPFH DOMAIN,CELL-PROLIFERATION,ALTERNATIVE OXIDASE,SACCHAROMYCES-CEREVISIAE,GENE-EXPRESSION,ARABIDOPSIS-THALIANA,M-AAA PROTEASE,REPLICATIVE LIFE-SPAN},
  language     = {eng},
  number       = {5},
  pages        = {275--282},
  title        = {Prohibitins: mitochondrial partners in development and stress response},
  url          = {http://dx.doi.org/10.1016/j.tplants.2010.02.002},
  volume       = {15},
  year         = {2010},
}

Chicago
Van Aken, Olivier, James Whelan, and Frank Van Breusegem. 2010. “Prohibitins: Mitochondrial Partners in Development and Stress Response.” Trends in Plant Science 15 (5): 275–282.
APA
Van Aken, O., Whelan, J., & Van Breusegem, F. (2010). Prohibitins: mitochondrial partners in development and stress response. TRENDS IN PLANT SCIENCE, 15(5), 275–282.
Vancouver
1.
Van Aken O, Whelan J, Van Breusegem F. Prohibitins: mitochondrial partners in development and stress response. TRENDS IN PLANT SCIENCE. 2010;15(5):275–82.
MLA
Van Aken, Olivier, James Whelan, and Frank Van Breusegem. “Prohibitins: Mitochondrial Partners in Development and Stress Response.” TRENDS IN PLANT SCIENCE 15.5 (2010): 275–282. Print.