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Functional modules in the Arabidopsis core cell cycle binary protein-protein interaction network

Joanna Boruc (UGent) , Hilde Van Den Daele (UGent) , Jens Hollunder (UGent) , Stephane Rombauts (UGent) , Evelien Mylle (UGent) , Pierre Hilson (UGent) , Dirk Inzé (UGent) , Lieven De Veylder (UGent) and Eugenia Russinova (UGent)
(2010) PLANT CELL. 22(4). p.1264-1280
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Abstract
As in other eukaryotes, cell division in plants is highly conserved and regulated by cyclin-dependent kinases (CDKs) that are themselves predominantly regulated at the posttranscriptional level by their association with proteins such as cyclins. Although over the last years the knowledge of the plant cell cycle has considerably increased, little is known on the assembly and regulation of the different CDK complexes. To map protein-protein interactions between core cell cycle proteins of Arabidopsis thaliana, a binary protein-protein interactome network was generated using two complementary high-throughput interaction assays, yeast two-hybrid and bimolecular fluorescence complementation. Pairwise interactions among 58 core cell cycle proteins were tested, resulting in 357 interactions, of which 293 have not been reported before. Integration of the binary interaction results with cell cycle phase-dependent expression information and localization data allowed the construction of a dynamic interaction network. The obtained interaction map constitutes a framework for further in-depth analysis of the cell cycle machinery.
Keywords
GENE COEXPRESSION NETWORKS, DEPENDENT KINASE, CDK-ACTIVATING KINASE, PLANT DEVELOPMENT, MITOTIC CYCLINS, M-PHASE, EXPRESSION, TRANSCRIPTION FACTORS, EARLY EMBRYOGENESIS, XENOPUS SUC1/CKS PROTEIN

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MLA
Boruc, Joanna, et al. “Functional Modules in the Arabidopsis Core Cell Cycle Binary Protein-Protein Interaction Network.” PLANT CELL, vol. 22, no. 4, 2010, pp. 1264–80, doi:10.1105/tpc.109.073635.
APA
Boruc, J., Van Den Daele, H., Hollunder, J., Rombauts, S., Mylle, E., Hilson, P., … Russinova, E. (2010). Functional modules in the Arabidopsis core cell cycle binary protein-protein interaction network. PLANT CELL, 22(4), 1264–1280. https://doi.org/10.1105/tpc.109.073635
Chicago author-date
Boruc, Joanna, Hilde Van Den Daele, Jens Hollunder, Stephane Rombauts, Evelien Mylle, Pierre Hilson, Dirk Inzé, Lieven De Veylder, and Eugenia Russinova. 2010. “Functional Modules in the Arabidopsis Core Cell Cycle Binary Protein-Protein Interaction Network.” PLANT CELL 22 (4): 1264–80. https://doi.org/10.1105/tpc.109.073635.
Chicago author-date (all authors)
Boruc, Joanna, Hilde Van Den Daele, Jens Hollunder, Stephane Rombauts, Evelien Mylle, Pierre Hilson, Dirk Inzé, Lieven De Veylder, and Eugenia Russinova. 2010. “Functional Modules in the Arabidopsis Core Cell Cycle Binary Protein-Protein Interaction Network.” PLANT CELL 22 (4): 1264–1280. doi:10.1105/tpc.109.073635.
Vancouver
1.
Boruc J, Van Den Daele H, Hollunder J, Rombauts S, Mylle E, Hilson P, et al. Functional modules in the Arabidopsis core cell cycle binary protein-protein interaction network. PLANT CELL. 2010;22(4):1264–80.
IEEE
[1]
J. Boruc et al., “Functional modules in the Arabidopsis core cell cycle binary protein-protein interaction network,” PLANT CELL, vol. 22, no. 4, pp. 1264–1280, 2010.
@article{1008270,
  abstract     = {{As in other eukaryotes, cell division in plants is highly conserved and regulated by cyclin-dependent kinases (CDKs) that are themselves predominantly regulated at the posttranscriptional level by their association with proteins such as cyclins. Although over the last years the knowledge of the plant cell cycle has considerably increased, little is known on the assembly and regulation of the different CDK complexes. To map protein-protein interactions between core cell cycle proteins of Arabidopsis thaliana, a binary protein-protein interactome network was generated using two complementary high-throughput interaction assays, yeast two-hybrid and bimolecular fluorescence complementation. Pairwise interactions among 58 core cell cycle proteins were tested, resulting in 357 interactions, of which 293 have not been reported before. Integration of the binary interaction results with cell cycle phase-dependent expression information and localization data allowed the construction of a dynamic interaction network. The obtained interaction map constitutes a framework for further in-depth analysis of the cell cycle machinery.}},
  author       = {{Boruc, Joanna and Van Den Daele, Hilde and Hollunder, Jens and Rombauts, Stephane and Mylle, Evelien and Hilson, Pierre and Inzé, Dirk and De Veylder, Lieven and Russinova, Eugenia}},
  issn         = {{1040-4651}},
  journal      = {{PLANT CELL}},
  keywords     = {{GENE COEXPRESSION NETWORKS,DEPENDENT KINASE,CDK-ACTIVATING KINASE,PLANT DEVELOPMENT,MITOTIC CYCLINS,M-PHASE,EXPRESSION,TRANSCRIPTION FACTORS,EARLY EMBRYOGENESIS,XENOPUS SUC1/CKS PROTEIN}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{1264--1280}},
  title        = {{Functional modules in the Arabidopsis core cell cycle binary protein-protein interaction network}},
  url          = {{http://dx.doi.org/10.1105/tpc.109.073635}},
  volume       = {{22}},
  year         = {{2010}},
}

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