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An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours

(2010) ONCOGENE. 29(24). p.3583-3592
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Abstract
Different classes of non-coding RNAs, including microRNAs, have recently been implicated in the process of tumourigenesis. In this study, we examined the expression and putative functions of a novel class of non-coding RNAs known as transcribed ultraconserved regions (T-UCRs) in neuroblastoma. Genome-wide expression pro. ling revealed correlations between specific T-UCR expression levels and important clinicogenetic parameters such as MYCN amplification status. A functional genomics approach based on the integration of multi-level transcriptome data was adapted to gain insights into T-UCR functions. Assignments of T-UCRs to cellular processes such as TP53 response, differentiation and proliferation were verified using various cellular model systems. For the first time, our results de. ne a T-UCR expression landscape in neuroblastoma and suggest widespread T-UCR involvement in diverse cellular processes that are deregulated in the process of tumourigenesis.
Keywords
T-UCR, neuroblastoma, non-coding RNA, NONCODING RNAS, MICRORNAS, EXPRESSION, PCR, ANTAGONISTS, ASSOCIATE, GENES, PATHWAY, MAPS, CELLS

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Citation

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Chicago
Mestdagh, Pieter, E Fredlund, Filip Pattyn, Ali Rihani, Tom Van Maerken, Joëlle Vermeulen, Candy Kumps, et al. 2010. “An Integrative Genomics Screen Uncovers ncRNA T-UCR Functions in Neuroblastoma Tumours.” Oncogene 29 (24): 3583–3592.
APA
Mestdagh, Pieter, Fredlund, E., Pattyn, F., Rihani, A., Van Maerken, T., Vermeulen, J., Kumps, C., et al. (2010). An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours. ONCOGENE, 29(24), 3583–3592.
Vancouver
1.
Mestdagh P, Fredlund E, Pattyn F, Rihani A, Van Maerken T, Vermeulen J, et al. An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours. ONCOGENE. 2010;29(24):3583–92.
MLA
Mestdagh, Pieter, E Fredlund, Filip Pattyn, et al. “An Integrative Genomics Screen Uncovers ncRNA T-UCR Functions in Neuroblastoma Tumours.” ONCOGENE 29.24 (2010): 3583–3592. Print.
@article{1004253,
  abstract     = {Different classes of non-coding RNAs, including microRNAs, have recently been implicated in the process of tumourigenesis. In this study, we examined the expression and putative functions of a novel class of non-coding RNAs known as transcribed ultraconserved regions (T-UCRs) in neuroblastoma. Genome-wide expression pro. ling revealed correlations between specific T-UCR expression levels and important clinicogenetic parameters such as MYCN amplification status. A functional genomics approach based on the integration of multi-level transcriptome data was adapted to gain insights into T-UCR functions. Assignments of T-UCRs to cellular processes such as TP53 response, differentiation and proliferation were verified using various cellular model systems. For the first time, our results de. ne a T-UCR expression landscape in neuroblastoma and suggest widespread T-UCR involvement in diverse cellular processes that are deregulated in the process of tumourigenesis.},
  author       = {Mestdagh, Pieter and Fredlund, E and Pattyn, Filip and Rihani, Ali and Van Maerken, Tom and Vermeulen, Jo{\"e}lle and Kumps, Candy and Menten, Bj{\"o}rn and De Preter, Katleen and Schramm, A and Schulte, J and Noguera, R and Schleiermacher, G and Janoueix-Lerosey, I and Laureys, Genevieve and Powel, R and Nittner, David and Marine, Jean-Christophe and Ringner, M and Speleman, Franki and Vandesompele, Jo},
  issn         = {0950-9232},
  journal      = {ONCOGENE},
  keyword      = {T-UCR,neuroblastoma,non-coding RNA,NONCODING RNAS,MICRORNAS,EXPRESSION,PCR,ANTAGONISTS,ASSOCIATE,GENES,PATHWAY,MAPS,CELLS},
  language     = {eng},
  number       = {24},
  pages        = {3583--3592},
  title        = {An integrative genomics screen uncovers ncRNA T-UCR functions in neuroblastoma tumours},
  url          = {http://dx.doi.org/10.1038/onc.2010.106},
  volume       = {29},
  year         = {2010},
}

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