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Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis

Lode Melis UGent, BERNARD VANDOOREN UGent, Elli Kruithof, Peggy Jacques UGent, Martine De Vos UGent, Herman Mielants, August Verbruggen UGent, Filip De Keyser UGent and Dirk Elewaut UGent (2010) ANNALS OF THE RHEUMATIC DISEASES. 69(3). p.618-623
abstract
Objectives Th17 cells are an effector T-cell population that plays a role in chronic inflammatory conditions and is dependent on IL-23 for their survival and expansion. More recently, a genetic association was discovered between polymorphisms in the gene coding for the IL-23 receptor and spondyloarthritis. This study aimed to evaluate the role of Th17-associated cytokines in spondyloarthritis pathogenesis by measuring their levels in the joints and circulation as well as correlating them with disease activity parameters. Methods Paired synovial fluid (SF), serum and synovial biopsies were obtained from 30 non-PsA (psoriatic arthritis) spondyloarthritis, 22 PsA and 22 rheumatoid arthritis (RA) patients. IL-17, IL-23 and CCL20 were measured by ELISA in the SF and serum of patients and correlated with systemic and local parameters of disease activity. Results Concentrations of CCL20, a major Th17-attracting chemokine, tended to be higher in the joints of RA than in spondyloarthritis patients. Interestingly, levels of CCL20 were markedly higher in SF as opposed to serum. In addition, there was a remarkable association between the expression of the Th17 cytokine system and the presence of intimal lining layer hyperplasia in RA. Also in the serum, there was a tendency for higher IL-23 levels in RA, which correlated strongly with disease activity parameters. Conclusions Th17-related cytokines are expressed in joints of spondyloarthritis as well as RA patients. IL-23 levels, however, correlate with disease activity parameters in RA only. These results point towards a differential regulation of the Th17 cytokine system in spondyloarthritis compared with RA.
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author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
GENOME-WIDE ASSOCIATION, NEUTROPHIL RECRUITMENT, T-CELLS, SELECTIVE RECRUITMENT, DENDRITIC CELLS, TH17 CELLS, IL-17, INTERLEUKIN-17, INFLAMMATION, CHEMOKINE
journal title
ANNALS OF THE RHEUMATIC DISEASES
Ann. Rheum. Dis.
volume
69
issue
3
pages
618 - 623
Web of Science type
Article
Web of Science id
000275458700028
JCR category
RHEUMATOLOGY
JCR impact factor
9.082 (2010)
JCR rank
1/29 (2010)
JCR quartile
1 (2010)
ISSN
0003-4967
DOI
10.1136/ard.2009.107649
language
English
UGent publication?
yes
classification
A1
copyright statement
I don't know the status of the copyright for this publication
id
1003744
handle
http://hdl.handle.net/1854/LU-1003744
date created
2010-07-06 12:00:24
date last changed
2016-12-19 15:44:23
@article{1003744,
  abstract     = {Objectives Th17 cells are an effector T-cell population that plays a role in chronic inflammatory conditions and is dependent on IL-23 for their survival and expansion. More recently, a genetic association was discovered between polymorphisms in the gene coding for the IL-23 receptor and spondyloarthritis. This study aimed to evaluate the role of Th17-associated cytokines in spondyloarthritis pathogenesis by measuring their levels in the joints and circulation as well as correlating them with disease activity parameters.
Methods Paired synovial fluid (SF), serum and synovial biopsies were obtained from 30 non-PsA (psoriatic arthritis) spondyloarthritis, 22 PsA and 22 rheumatoid arthritis (RA) patients. IL-17, IL-23 and CCL20 were measured by ELISA in the SF and serum of patients and correlated with systemic and local parameters of disease activity.
Results Concentrations of CCL20, a major Th17-attracting chemokine, tended to be higher in the joints of RA than in spondyloarthritis patients. Interestingly, levels of CCL20 were markedly higher in SF as opposed to serum. In addition, there was a remarkable association between the expression of the Th17 cytokine system and the presence of intimal lining layer hyperplasia in RA. Also in the serum, there was a tendency for higher IL-23 levels in RA, which correlated strongly with disease activity parameters.
Conclusions Th17-related cytokines are expressed in joints of spondyloarthritis as well as RA patients. IL-23 levels, however, correlate with disease activity parameters in RA only. These results point towards a differential regulation of the Th17 cytokine system in spondyloarthritis compared with RA.},
  author       = {Melis, Lode and VANDOOREN, BERNARD and Kruithof, Elli and Jacques, Peggy and De Vos, Martine and Mielants, Herman and Verbruggen, August and De Keyser, Filip and Elewaut, Dirk},
  issn         = {0003-4967},
  journal      = {ANNALS OF THE RHEUMATIC DISEASES},
  keyword      = {GENOME-WIDE ASSOCIATION,NEUTROPHIL RECRUITMENT,T-CELLS,SELECTIVE RECRUITMENT,DENDRITIC CELLS,TH17 CELLS,IL-17,INTERLEUKIN-17,INFLAMMATION,CHEMOKINE},
  language     = {eng},
  number       = {3},
  pages        = {618--623},
  title        = {Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis},
  url          = {http://dx.doi.org/10.1136/ard.2009.107649},
  volume       = {69},
  year         = {2010},
}

Chicago
Melis, Lode, BERNARD VANDOOREN, Elli Kruithof, Peggy Jacques, Martine De Vos, Herman Mielants, August Verbruggen, Filip De Keyser, and Dirk Elewaut. 2010. “Systemic Levels of IL-23 Are Strongly Associated with Disease Activity in Rheumatoid Arthritis but Not Spondyloarthritis.” Annals of the Rheumatic Diseases 69 (3): 618–623.
APA
Melis, Lode, VANDOOREN, B., Kruithof, E., Jacques, P., De Vos, M., Mielants, H., Verbruggen, A., et al. (2010). Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis. ANNALS OF THE RHEUMATIC DISEASES, 69(3), 618–623.
Vancouver
1.
Melis L, VANDOOREN B, Kruithof E, Jacques P, De Vos M, Mielants H, et al. Systemic levels of IL-23 are strongly associated with disease activity in rheumatoid arthritis but not spondyloarthritis. ANNALS OF THE RHEUMATIC DISEASES. 2010;69(3):618–23.
MLA
Melis, Lode, BERNARD VANDOOREN, Elli Kruithof, et al. “Systemic Levels of IL-23 Are Strongly Associated with Disease Activity in Rheumatoid Arthritis but Not Spondyloarthritis.” ANNALS OF THE RHEUMATIC DISEASES 69.3 (2010): 618–623. Print.