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The unobtrusive majority: mononucleated bone resorbing cells in teleost fish and mammals

Paul Witten (UGent) and Ann Huysseune (UGent)
(2010) JOURNAL OF APPLIED ICHTHYOLOGY. 26(2). p.225-229
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Abstract
The canonical view of a mammalian (usually shown as human) bone resorbing cell is that of a giant macrophage-like cell (osteoclast) that dissolves bone minerals and digests bone matrix proteins. The cells' presence and activity is easily recognised based on three distinct morphological features: (i) multinuclearity, (ii) a multiply folded apical cell membrane (ruffled border), and (iii) deep lacunae (Howship's lacunae) that the cells eroded into the bone surface. Mononucleated osteoclasts without these features are considered to be inactive precursors. We challenge the view that bone resorbing cells must be multinucleated giant cells, based on our comparative studies on the teleost skeleton, on what is currently known - but often disregarded - about mononucleated mammalian osteoclasts, and on what is know about osteocytic osteolysis.
Keywords
BONE RESORPTION, OSTEOCLASTS, ACELLULAR BONE, TELEOSTS

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Chicago
Witten, Paul, and Ann Huysseune. 2010. “The Unobtrusive Majority: Mononucleated Bone Resorbing Cells in Teleost Fish and Mammals.” Ed. Paul Witten, Ann Huysseune, Harald Rosenthal, and M Leonor Cancela. Journal of Applied Ichthyology 26 (2): 225–229.
APA
Witten, P., & Huysseune, A. (2010). The unobtrusive majority: mononucleated bone resorbing cells in teleost fish and mammals. (P. Witten, A. Huysseune, H. Rosenthal, & M. L. Cancela, Eds.)JOURNAL OF APPLIED ICHTHYOLOGY, 26(2), 225–229. Presented at the Interdisciplinary Approaches in Fish Skeletal Biology.
Vancouver
1.
Witten P, Huysseune A. The unobtrusive majority: mononucleated bone resorbing cells in teleost fish and mammals. Witten P, Huysseune A, Rosenthal H, Cancela ML, editors. JOURNAL OF APPLIED ICHTHYOLOGY. 2010;26(2):225–9.
MLA
Witten, Paul, and Ann Huysseune. “The Unobtrusive Majority: Mononucleated Bone Resorbing Cells in Teleost Fish and Mammals.” Ed. Paul Witten et al. JOURNAL OF APPLIED ICHTHYOLOGY 26.2 (2010): 225–229. Print.
@article{1002319,
  abstract     = {The canonical view of a mammalian (usually shown as human) bone resorbing cell is that of a giant macrophage-like cell (osteoclast) that dissolves bone minerals and digests bone matrix proteins. The cells' presence and activity is easily recognised based on three distinct morphological features: (i) multinuclearity, (ii) a multiply folded apical cell membrane (ruffled border), and (iii) deep lacunae (Howship's lacunae) that the cells eroded into the bone surface. Mononucleated osteoclasts without these features are considered to be inactive precursors. We challenge the view that bone resorbing cells must be multinucleated giant cells, based on our comparative studies on the teleost skeleton, on what is currently known - but often disregarded - about mononucleated mammalian osteoclasts, and on what is know about osteocytic osteolysis.},
  author       = {Witten, Paul and Huysseune, Ann},
  editor       = {Witten, Paul and Huysseune, Ann and Rosenthal, Harald and Cancela, M Leonor},
  issn         = {0175-8659},
  journal      = {JOURNAL OF APPLIED ICHTHYOLOGY},
  keyword      = {BONE RESORPTION,OSTEOCLASTS,ACELLULAR BONE,TELEOSTS},
  language     = {eng},
  location     = {Tavira, Portugal},
  number       = {2},
  pages        = {225--229},
  title        = {The unobtrusive majority: mononucleated bone resorbing cells in teleost fish and mammals},
  url          = {http://dx.doi.org/10.1111/j.1439-0426.2010.01410.x},
  volume       = {26},
  year         = {2010},
}

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