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The unobtrusive majority: mononucleated bone resorbing cells in teleost fish and mammals

Paul Witten UGent and Ann Huysseune UGent (2010) JOURNAL OF APPLIED ICHTHYOLOGY. 26(2). p.225-229
abstract
The canonical view of a mammalian (usually shown as human) bone resorbing cell is that of a giant macrophage-like cell (osteoclast) that dissolves bone minerals and digests bone matrix proteins. The cells' presence and activity is easily recognised based on three distinct morphological features: (i) multinuclearity, (ii) a multiply folded apical cell membrane (ruffled border), and (iii) deep lacunae (Howship's lacunae) that the cells eroded into the bone surface. Mononucleated osteoclasts without these features are considered to be inactive precursors. We challenge the view that bone resorbing cells must be multinucleated giant cells, based on our comparative studies on the teleost skeleton, on what is currently known - but often disregarded - about mononucleated mammalian osteoclasts, and on what is know about osteocytic osteolysis.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
BONE RESORPTION, OSTEOCLASTS, ACELLULAR BONE, TELEOSTS
journal title
JOURNAL OF APPLIED ICHTHYOLOGY
J. Appl. Ichthyol.
editor
Paul Witten UGent, Ann Huysseune UGent, Harald Rosenthal and M Leonor Cancela
volume
26
issue
2
issue title
Proceedings of the first International Workshop 'Interdisciplinary Approaches in Fish Skeletal Biology'
pages
225 - 229
conference name
Interdisciplinary Approaches in Fish Skeletal Biology
conference location
Tavira, Portugal
conference start
2009-04-27
conference end
2009-04-29
Web of Science type
Review
Web of Science id
000276655800018
JCR category
FISHERIES
JCR impact factor
0.945 (2010)
JCR rank
26/46 (2010)
JCR quartile
3 (2010)
ISSN
0175-8659
DOI
10.1111/j.1439-0426.2010.01410.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1002319
handle
http://hdl.handle.net/1854/LU-1002319
date created
2010-07-05 12:25:21
date last changed
2010-08-04 10:16:00
@article{1002319,
  abstract     = {The canonical view of a mammalian (usually shown as human) bone resorbing cell is that of a giant macrophage-like cell (osteoclast) that dissolves bone minerals and digests bone matrix proteins. The cells' presence and activity is easily recognised based on three distinct morphological features: (i) multinuclearity, (ii) a multiply folded apical cell membrane (ruffled border), and (iii) deep lacunae (Howship's lacunae) that the cells eroded into the bone surface. Mononucleated osteoclasts without these features are considered to be inactive precursors. We challenge the view that bone resorbing cells must be multinucleated giant cells, based on our comparative studies on the teleost skeleton, on what is currently known - but often disregarded - about mononucleated mammalian osteoclasts, and on what is know about osteocytic osteolysis.},
  author       = {Witten, Paul and Huysseune, Ann},
  editor       = {Witten, Paul and Huysseune, Ann and Rosenthal, Harald and Cancela, M Leonor},
  issn         = {0175-8659},
  journal      = {JOURNAL OF APPLIED ICHTHYOLOGY},
  keyword      = {BONE RESORPTION,OSTEOCLASTS,ACELLULAR BONE,TELEOSTS},
  language     = {eng},
  location     = {Tavira, Portugal},
  number       = {2},
  pages        = {225--229},
  title        = {The unobtrusive majority: mononucleated bone resorbing cells in teleost fish and mammals},
  url          = {http://dx.doi.org/10.1111/j.1439-0426.2010.01410.x},
  volume       = {26},
  year         = {2010},
}

Chicago
Witten, Paul, and Ann Huysseune. 2010. “The Unobtrusive Majority: Mononucleated Bone Resorbing Cells in Teleost Fish and Mammals.” Ed. Paul Witten, Ann Huysseune, Harald Rosenthal, and M Leonor Cancela. Journal of Applied Ichthyology 26 (2): 225–229.
APA
Witten, P., & Huysseune, A. (2010). The unobtrusive majority: mononucleated bone resorbing cells in teleost fish and mammals. (P. Witten, A. Huysseune, H. Rosenthal, & M. L. Cancela, Eds.)JOURNAL OF APPLIED ICHTHYOLOGY, 26(2), 225–229. Presented at the Interdisciplinary Approaches in Fish Skeletal Biology.
Vancouver
1.
Witten P, Huysseune A. The unobtrusive majority: mononucleated bone resorbing cells in teleost fish and mammals. Witten P, Huysseune A, Rosenthal H, Cancela ML, editors. JOURNAL OF APPLIED ICHTHYOLOGY. 2010;26(2):225–9.
MLA
Witten, Paul, and Ann Huysseune. “The Unobtrusive Majority: Mononucleated Bone Resorbing Cells in Teleost Fish and Mammals.” Ed. Paul Witten et al. JOURNAL OF APPLIED ICHTHYOLOGY 26.2 (2010): 225–229. Print.