Thiotepa-induced cutaneous toxicity in pediatric patients : case report and implementation of preventive care guidelines
- Author
- Guy Van Schandevyl and Tieneke Bauters (UGent)
- Organization
- Abstract
- Thiotepa, a highly lipophilic, alkylating agent, and/or its active metabolites may be excreted in part via skin in patients receiving high-dose therapy. We present a case of cutaneous toxicity observed in a 4.5-year-old girl patient with medulloblastoma treated with a high-dose thiotepa conditioning regimen before autologous stem cell transplantation. Skin lesions, as well as their pattern and locations, were evocative of thiotepa toxidermia. After the case herein described, preventive care guidelines were implemented in our unit as from 2014. A retrospective follow-up of 26 pediatric patients receiving thiotepa prior to stem cell transplantation was performed until March 2018. In this series of patients, only one patient experienced cutaneous toxicity as reported herein. Thereafter, only mild cutaneous toxicity was observed, even with double or triple transplantation protocols with high-dose thiotepa. Clear preventive care instructions should be detailed in the Summary of Product Characteristics in order to minimize the cutaneous toxicity of thiotepa.
- Keywords
- Thiotepa, cutaneous toxicity, case report, guidelines, children
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Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01M1ENFD9R4VGG2VQ2DCGJWRV9
- MLA
- Van Schandevyl, Guy, and Tieneke Bauters. “Thiotepa-Induced Cutaneous Toxicity in Pediatric Patients : Case Report and Implementation of Preventive Care Guidelines.” JOURNAL OF ONCOLOGY PHARMACY PRACTICE, vol. 25, no. 3, 2019, pp. 689–93, doi:10.1177/1078155218796905.
- APA
- Van Schandevyl, G., & Bauters, T. (2019). Thiotepa-induced cutaneous toxicity in pediatric patients : case report and implementation of preventive care guidelines. JOURNAL OF ONCOLOGY PHARMACY PRACTICE, 25(3), 689–693. https://doi.org/10.1177/1078155218796905
- Chicago author-date
- Van Schandevyl, Guy, and Tieneke Bauters. 2019. “Thiotepa-Induced Cutaneous Toxicity in Pediatric Patients : Case Report and Implementation of Preventive Care Guidelines.” JOURNAL OF ONCOLOGY PHARMACY PRACTICE 25 (3): 689–93. https://doi.org/10.1177/1078155218796905.
- Chicago author-date (all authors)
- Van Schandevyl, Guy, and Tieneke Bauters. 2019. “Thiotepa-Induced Cutaneous Toxicity in Pediatric Patients : Case Report and Implementation of Preventive Care Guidelines.” JOURNAL OF ONCOLOGY PHARMACY PRACTICE 25 (3): 689–693. doi:10.1177/1078155218796905.
- Vancouver
- 1.Van Schandevyl G, Bauters T. Thiotepa-induced cutaneous toxicity in pediatric patients : case report and implementation of preventive care guidelines. JOURNAL OF ONCOLOGY PHARMACY PRACTICE. 2019;25(3):689–93.
- IEEE
- [1]G. Van Schandevyl and T. Bauters, “Thiotepa-induced cutaneous toxicity in pediatric patients : case report and implementation of preventive care guidelines,” JOURNAL OF ONCOLOGY PHARMACY PRACTICE, vol. 25, no. 3, pp. 689–693, 2019.
@article{01M1ENFD9R4VGG2VQ2DCGJWRV9,
abstract = {{Thiotepa, a highly lipophilic, alkylating agent, and/or its active metabolites may be excreted in part via skin in patients receiving high-dose therapy. We present a case of cutaneous toxicity observed in a 4.5-year-old girl patient with medulloblastoma treated with a high-dose thiotepa conditioning regimen before autologous stem cell transplantation. Skin lesions, as well as their pattern and locations, were evocative of thiotepa toxidermia. After the case herein described, preventive care guidelines were implemented in our unit as from 2014. A retrospective follow-up of 26 pediatric patients receiving thiotepa prior to stem cell transplantation was performed until March 2018. In this series of patients, only one patient experienced cutaneous toxicity as reported herein. Thereafter, only mild cutaneous toxicity was observed, even with double or triple transplantation protocols with high-dose thiotepa. Clear preventive care instructions should be detailed in the Summary of Product Characteristics in order to minimize the cutaneous toxicity of thiotepa.}},
author = {{Van Schandevyl, Guy and Bauters, Tieneke}},
issn = {{1078-1552}},
journal = {{JOURNAL OF ONCOLOGY PHARMACY PRACTICE}},
keywords = {{Thiotepa,cutaneous toxicity,case report,guidelines,children}},
language = {{eng}},
number = {{3}},
pages = {{689--693}},
title = {{Thiotepa-induced cutaneous toxicity in pediatric patients : case report and implementation of preventive care guidelines}},
url = {{http://doi.org/10.1177/1078155218796905}},
volume = {{25}},
year = {{2019}},
}
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