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New phage in town : novel vibriophage-vB_VibS_KarBoss for targeted control of vibriosis in aquaculture amid climate change

Kevin Mwangi (UGent) , Sangeetha Chidananda, Apoorva R. Kenjar, Pallavi Bhat Ajakkala, Sujana Prabell, May Ochieng (UGent) , Célia Pas (UGent) , Yves Briers (UGent) , Gowri Amanda Hettiarachchi (UGent) , Sieglinde Coppens (UGent) , et al.
(2026) PHAGE-THERAPY APPLICATIONS AND RESEARCH.
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Abstract
Antibiotic-resistant Vibrio species pose a threat in aquaculture. This study evaluates the potential of phage vB_VibS_KarBoss under climate-influenced water conditions such as temperature, pH, and salinity. vB_VibS_KarBoss, isolated from fish market wastes, inhibited 48 of 89 nonredundant autochthonous Vibrio isolates. With a 10-min latent period and a burst size of 3 phages per cell, vB_VibS_KarBoss inhibited the growth of pathogenic species including Vibrio campbellii and Vibrio parahaemolyticus. With only 16.4% intergenomic similarity to related phages, we propose a new phage genus, KarBossvirus, for consideration by the International Committee on Taxonomy of Viruses. Considering the robustness of Artemia and their sensitivity to changes in environmental conditions, the virulence of the Vibrio isolates resulting in Artemia mortality and the efficacy of vB_VibS_KarBoss in these altered water conditions were studied. Results support the potential importance of vB_VibS_KarBoss in biocontrol in its ability to rescue >50% Artemia (p < 0.01) from mortality due to vibriosis.
Keywords
Caudoviricetes, climate-driven virulence, phage genomes, Vibrio campbellii, Vibrio parahaemolyticus, vibriophage, HARVEYI, SHRIMP, PARAHAEMOLYTICUS, BACTERIOPHAGE, BIOCONTROL, RISK

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MLA
Mwangi, Kevin, et al. “New Phage in Town : Novel Vibriophage-VB_VibS_KarBoss for Targeted Control of Vibriosis in Aquaculture amid Climate Change.” PHAGE-THERAPY APPLICATIONS AND RESEARCH, 2026, doi:10.1177/26416549261422066.
APA
Mwangi, K., Chidananda, S., Kenjar, A. R., Ajakkala, P. B., Prabell, S., Ochieng, M., … Bossier, P. (2026). New phage in town : novel vibriophage-vB_VibS_KarBoss for targeted control of vibriosis in aquaculture amid climate change. PHAGE-THERAPY APPLICATIONS AND RESEARCH. https://doi.org/10.1177/26416549261422066
Chicago author-date
Mwangi, Kevin, Sangeetha Chidananda, Apoorva R. Kenjar, Pallavi Bhat Ajakkala, Sujana Prabell, May Ochieng, Célia Pas, et al. 2026. “New Phage in Town : Novel Vibriophage-VB_VibS_KarBoss for Targeted Control of Vibriosis in Aquaculture amid Climate Change.” PHAGE-THERAPY APPLICATIONS AND RESEARCH. https://doi.org/10.1177/26416549261422066.
Chicago author-date (all authors)
Mwangi, Kevin, Sangeetha Chidananda, Apoorva R. Kenjar, Pallavi Bhat Ajakkala, Sujana Prabell, May Ochieng, Célia Pas, Yves Briers, Gowri Amanda Hettiarachchi, Sieglinde Coppens, Sebastiaan Theuns, Juliet Roshini Mohan Raj, Iddya Karunasagar, Indrani Karunasagar, and Peter Bossier. 2026. “New Phage in Town : Novel Vibriophage-VB_VibS_KarBoss for Targeted Control of Vibriosis in Aquaculture amid Climate Change.” PHAGE-THERAPY APPLICATIONS AND RESEARCH. doi:10.1177/26416549261422066.
Vancouver
1.
Mwangi K, Chidananda S, Kenjar AR, Ajakkala PB, Prabell S, Ochieng M, et al. New phage in town : novel vibriophage-vB_VibS_KarBoss for targeted control of vibriosis in aquaculture amid climate change. PHAGE-THERAPY APPLICATIONS AND RESEARCH. 2026;
IEEE
[1]
K. Mwangi et al., “New phage in town : novel vibriophage-vB_VibS_KarBoss for targeted control of vibriosis in aquaculture amid climate change,” PHAGE-THERAPY APPLICATIONS AND RESEARCH, 2026.
@article{01KKXQHP19CPM298T59WB05WYM,
  abstract     = {{Antibiotic-resistant Vibrio species pose a threat in aquaculture. This study evaluates the potential of phage vB_VibS_KarBoss under climate-influenced water conditions such as temperature, pH, and salinity. vB_VibS_KarBoss, isolated from fish market wastes, inhibited 48 of 89 nonredundant autochthonous Vibrio isolates. With a 10-min latent period and a burst size of 3 phages per cell, vB_VibS_KarBoss inhibited the growth of pathogenic species including Vibrio campbellii and Vibrio parahaemolyticus. With only 16.4% intergenomic similarity to related phages, we propose a new phage genus, KarBossvirus, for consideration by the International Committee on Taxonomy of Viruses. Considering the robustness of Artemia and their sensitivity to changes in environmental conditions, the virulence of the Vibrio isolates resulting in Artemia mortality and the efficacy of vB_VibS_KarBoss in these altered water conditions were studied. Results support the potential importance of vB_VibS_KarBoss in biocontrol in its ability to rescue >50% Artemia (p < 0.01) from mortality due to vibriosis.}},
  author       = {{Mwangi, Kevin and Chidananda, Sangeetha and Kenjar, Apoorva R. and Ajakkala, Pallavi Bhat and Prabell, Sujana and Ochieng, May and Pas, Célia and Briers, Yves and Hettiarachchi, Gowri Amanda and Coppens, Sieglinde and Theuns, Sebastiaan and Raj, Juliet Roshini Mohan and Karunasagar, Iddya and Karunasagar, Indrani and Bossier, Peter}},
  issn         = {{2641-6549}},
  journal      = {{PHAGE-THERAPY APPLICATIONS AND RESEARCH}},
  keywords     = {{Caudoviricetes,climate-driven virulence,phage genomes,Vibrio campbellii,Vibrio parahaemolyticus,vibriophage,HARVEYI,SHRIMP,PARAHAEMOLYTICUS,BACTERIOPHAGE,BIOCONTROL,RISK}},
  language     = {{eng}},
  pages        = {{9}},
  title        = {{New phage in town : novel vibriophage-vB_VibS_KarBoss for targeted control of vibriosis in aquaculture amid climate change}},
  url          = {{http://doi.org/10.1177/26416549261422066}},
  year         = {{2026}},
}
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