@article{01KKKECFJ27AJ3JRACA6Y9DBK2,
  abstract     = {{The growing threat of multidrug-resistant Klebsiella pneumoniae, coupled with its role in gut colonisation, has intensified the search for new treatments, including bacteriophage therapy. Despite increasing documentation of Klebsiella-targeting phages, clinical applications remain limited, with key phage-bacteria interactions still poorly understood. A major obstacle is fragmented access to well-characterised phage-bacteria pairings, restricting the collective advancement of therapeutic and mechanistic insights. To address this gap, we created the Klebsiella Phage Collection (KlebPhaCol), an open resource comprising 52 phages and 74 Klebsiella isolates, characterised at phenotypic and genomic levels. These phages span six families-including a novel family, Felixviridae, associated with the human gut-and target 20 sequence types (including ST258, ST11, and ST14) and 19 capsular-locus types (including KL1 and KL2), across 6 Klebsiella species. Freely accessible at www.klebphacol.org, KlebPhaCol invites the scientific community to both use and contribute to this resource, fostering collaborative research and a deeper understanding of Klebsiella-phage interactions beyond therapeutic use. Multidrug-resistant Klebsiella pneumoniae is a critical global health challenge. Bacteriophages (phages) could offer new therapies, but progress has been slowed by fragmented resources. KlebPhaCol addresses this gap as the first open, community-driven Klebsiella phage collection. It brings together physical samples (52 phages and 74 Klebsiella isolates) alongside extensive genomic, phenotypic, and host-range data, all freely accessible via www.klebphacol.org. The collection includes globally relevant clones, spans six phage families, and revealed a new gut-associated phage family, Felixviridae. Crucially, KlebPhaCol is designed to grow: researchers worldwide can deposit new strains and phages or add fresh analyses to existing ones, creating a sustainable platform for therapeutic development and fundamental microbiology.}},
  articleno    = {{gkaf1122}},
  author       = {{Rothschild-Rodriguez, Daniela and Lambon, Kai S and Kushwaha, Simran Krishnakant and Garushyants, Sofya K and Ertelt, Moritz and Łątka, Agnieszka and Costa, Ana Rita and Mantzouratou, Anna and King, Claire and Boeckaerts, Dimitri and Sheridan, Elizabeth and Koonin, Eugene V and Merrick, Francesca and Drobniewski, Francis and De Angelis, Ilaria and Saeed, Kordo and Martin, Macy and Sutton, J Mark and Wand, Matthew E and Andrew, Michael and Hedges, Morgen and Brouns, Stan J J and Haas, Pieter-Jan and Lawson, Sophie T and Fordham, Stephen M E and Lee, Yan-Jiun and Wu, Yi and Briers, Yves and Braun, Peter and Weigele, Peter R and Nobrega, Franklin L}},
  issn         = {{0305-1048}},
  journal      = {{NUCLEIC ACIDS RESEARCH}},
  keywords     = {{TRANSFER-RNA GENES,GUT MICROBIOTA,PNEUMONIAE,BACTERIA,GENOME,SEROTYPE,CLASSIFICATION,EPIDEMIOLOGY,ANTIBIOTICS,DISCOVERY}},
  language     = {{eng}},
  number       = {{21}},
  pages        = {{23}},
  title        = {{KlebPhaCol : a community-driven resource for Klebsiella research identified a novel phage family}},
  url          = {{http://doi.org/10.1093/nar/gkaf1122}},
  volume       = {{53}},
  year         = {{2025}},
}

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