128 × 128-Pixel current-assisted photonic sampler image sensor and camera system for macroscale fluorescence lifetime imaging with multiexposure for extended dynamic range
- Author
- Thomas Van den Dries, Thomas Lapauw, Simone Janssen (UGent) , Jeroen De Geeter, Jonathan Vrijsen, Wannes Nevens, Sophie Hernot, Maarten Kuijk and Hans Ingelberts
- Organization
- Project
- Abstract
- A 128×128-pixel current-assisted photonic sampler (CAPS) image sensor is designed for macroscale fluorescence lifetime imaging (MFLI). Current assistance is used for swift detection and time gating of the photogenerated carriers within the whole substrate. The sensor is fabricated in a commercial 350-nm CMOS process on a 15- μ m epilayer, with 19- μ m pixels and a 62% FF. The pixel features gating widths below 1 ns subject to a 42-ps standard deviation on the gate width uniformity and a 27-ps standard deviation on its temporal position. The pixel has a quantum efficiency (QE) above 40% for near-infrared (NIR) wavelengths, whereas the peak QE is 60% at 675 nm. The gate’s intrinsic decay is observed to be 280 ps, which allows for the MFLI of subnanosecond lifetime dyes. A multiexposure method has been implemented, where the pixel is nondestructively read-out multiple times—with different exposure times—after each reset. This allows for imaging with an extended dynamic range (DR) and is validated on commercial fluorescence phantoms. The MFLI capabilities are further demonstrated in a preclinical experiment.
- Keywords
- Fluorescence, Photonics, Electrons, Cameras, Substrates, Electric potential, Switches, Image sensors, Electric fields, Voltage, CMOS image sensor (CIS), current-assisted photonic sampler (CAPS), fluorescence lifetime imaging (FLI), near-infrared (NIR), photonic demodulation, time-gated fluorescence imaging, time-gating, time-resolved
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01KJMRYFQHYNWEABMC0RN39T0C
- MLA
- Van den Dries, Thomas, et al. “128 × 128-Pixel Current-Assisted Photonic Sampler Image Sensor and Camera System for Macroscale Fluorescence Lifetime Imaging with Multiexposure for Extended Dynamic Range.” IEEE SENSORS JOURNAL, vol. 25, no. 24, 2025, pp. 43900–08, doi:10.1109/jsen.2025.3626602.
- APA
- Van den Dries, T., Lapauw, T., Janssen, S., De Geeter, J., Vrijsen, J., Nevens, W., … Ingelberts, H. (2025). 128 × 128-Pixel current-assisted photonic sampler image sensor and camera system for macroscale fluorescence lifetime imaging with multiexposure for extended dynamic range. IEEE SENSORS JOURNAL, 25(24), 43900–43908. https://doi.org/10.1109/jsen.2025.3626602
- Chicago author-date
- Van den Dries, Thomas, Thomas Lapauw, Simone Janssen, Jeroen De Geeter, Jonathan Vrijsen, Wannes Nevens, Sophie Hernot, Maarten Kuijk, and Hans Ingelberts. 2025. “128 × 128-Pixel Current-Assisted Photonic Sampler Image Sensor and Camera System for Macroscale Fluorescence Lifetime Imaging with Multiexposure for Extended Dynamic Range.” IEEE SENSORS JOURNAL 25 (24): 43900–908. https://doi.org/10.1109/jsen.2025.3626602.
- Chicago author-date (all authors)
- Van den Dries, Thomas, Thomas Lapauw, Simone Janssen, Jeroen De Geeter, Jonathan Vrijsen, Wannes Nevens, Sophie Hernot, Maarten Kuijk, and Hans Ingelberts. 2025. “128 × 128-Pixel Current-Assisted Photonic Sampler Image Sensor and Camera System for Macroscale Fluorescence Lifetime Imaging with Multiexposure for Extended Dynamic Range.” IEEE SENSORS JOURNAL 25 (24): 43900–43908. doi:10.1109/jsen.2025.3626602.
- Vancouver
- 1.Van den Dries T, Lapauw T, Janssen S, De Geeter J, Vrijsen J, Nevens W, et al. 128 × 128-Pixel current-assisted photonic sampler image sensor and camera system for macroscale fluorescence lifetime imaging with multiexposure for extended dynamic range. IEEE SENSORS JOURNAL. 2025;25(24):43900–8.
- IEEE
- [1]T. Van den Dries et al., “128 × 128-Pixel current-assisted photonic sampler image sensor and camera system for macroscale fluorescence lifetime imaging with multiexposure for extended dynamic range,” IEEE SENSORS JOURNAL, vol. 25, no. 24, pp. 43900–43908, 2025.
@article{01KJMRYFQHYNWEABMC0RN39T0C,
abstract = {{A 128×128-pixel current-assisted photonic sampler (CAPS) image sensor is designed for macroscale fluorescence lifetime imaging (MFLI). Current assistance is used for swift detection and time gating of the photogenerated carriers within the whole substrate. The sensor is fabricated in a commercial 350-nm CMOS process on a 15- μ m epilayer, with 19- μ m pixels and a 62% FF. The pixel features gating widths below 1 ns subject to a 42-ps standard deviation on the gate width uniformity and a 27-ps standard deviation on its temporal position. The pixel has a quantum efficiency (QE) above 40% for near-infrared (NIR) wavelengths, whereas the peak QE is 60% at 675 nm. The gate’s intrinsic decay is observed to be 280 ps, which allows for the MFLI of subnanosecond lifetime dyes. A multiexposure method has been implemented, where the pixel is nondestructively read-out multiple times—with different exposure times—after each reset. This allows for imaging with an extended dynamic range (DR) and is validated on commercial fluorescence phantoms. The MFLI capabilities are further demonstrated in a preclinical experiment.}},
author = {{Van den Dries, Thomas and Lapauw, Thomas and Janssen, Simone and De Geeter, Jeroen and Vrijsen, Jonathan and Nevens, Wannes and Hernot, Sophie and Kuijk, Maarten and Ingelberts, Hans}},
issn = {{1530-437X}},
journal = {{IEEE SENSORS JOURNAL}},
keywords = {{Fluorescence,Photonics,Electrons,Cameras,Substrates,Electric potential,Switches,Image sensors,Electric fields,Voltage,CMOS image sensor (CIS),current-assisted photonic sampler (CAPS),fluorescence lifetime imaging (FLI),near-infrared (NIR),photonic demodulation,time-gated fluorescence imaging,time-gating,time-resolved}},
language = {{eng}},
number = {{24}},
pages = {{43900--43908}},
title = {{128 × 128-Pixel current-assisted photonic sampler image sensor and camera system for macroscale fluorescence lifetime imaging with multiexposure for extended dynamic range}},
url = {{http://doi.org/10.1109/jsen.2025.3626602}},
volume = {{25}},
year = {{2025}},
}
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