Is there evidence of diagnostic and treatment gaps for LUTS in post‐menopausal women with genitourinary syndrome of the menopause? ICI‐RS 2025
- Author
- Apostolos Apostolidis, Ana Sofia Da Silva, Thomas Gray, Vik Khullar, Rayan Mohamed‐Ahmed, Efstathios Papaefstathiou, Mauro Van den Ende (UGent) , Alan Wein, Paul Abrams and Dudley Robinson
- Organization
- Abstract
- Aims This report, from the International Consultation on Incontinence-Research Society, aims to evaluate the existing evidence and identify diagnostic and treatment gaps for Lower Urinary Tract Symptoms (LUTS) in post-menopausal women with Genitourinary Syndrome of Menopause (GSM). Methods An overview on the current literature, including pathophysiology, diagnosis and management of GSM associated LUTS, including incontinence, overactive bladder, underactive bladder and recurrent urinary tract infections (rUTIs). Results Significant gaps in the literature were identified. GSM is underdiagnosed and the interplay between hormonal changes in the postmenopausal period on LUTS remains poorly understood. Diagnostic methods for rUTIs lack sensitivity and the role of the urinary microbiome is emerging. Current treatments, including topical oestrogens and systemic hormone therapy, lack long-term efficacy data on LUTS. Evidence for regenerative medicine techniques remain limited by low-quality studies and short-term follow up. Conclusion There is lack of high-quality evidence, which hinders the optimal management of LUTS in post-menopausal women with GSM. The panel proposes targeted research questions, focusing on the hormonal impact on the lower urinary tract, advancing diagnostics and robust clinical trials for existing and novel therapies, to bridge current gaps in the literature and improve patient care.
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01KAZX0T4RGQJQQJRMZAH6YYKV
- MLA
- Apostolidis, Apostolos, et al. “Is There Evidence of Diagnostic and Treatment Gaps for LUTS in Post‐menopausal Women with Genitourinary Syndrome of the Menopause? ICI‐RS 2025.” NEUROUROLOGY AND URODYNAMICS, 2025, doi:10.1002/nau.70173.
- APA
- Apostolidis, A., Da Silva, A. S., Gray, T., Khullar, V., Mohamed‐Ahmed, R., Papaefstathiou, E., … Robinson, D. (2025). Is there evidence of diagnostic and treatment gaps for LUTS in post‐menopausal women with genitourinary syndrome of the menopause? ICI‐RS 2025. NEUROUROLOGY AND URODYNAMICS. https://doi.org/10.1002/nau.70173
- Chicago author-date
- Apostolidis, Apostolos, Ana Sofia Da Silva, Thomas Gray, Vik Khullar, Rayan Mohamed‐Ahmed, Efstathios Papaefstathiou, Mauro Van den Ende, Alan Wein, Paul Abrams, and Dudley Robinson. 2025. “Is There Evidence of Diagnostic and Treatment Gaps for LUTS in Post‐menopausal Women with Genitourinary Syndrome of the Menopause? ICI‐RS 2025.” NEUROUROLOGY AND URODYNAMICS. https://doi.org/10.1002/nau.70173.
- Chicago author-date (all authors)
- Apostolidis, Apostolos, Ana Sofia Da Silva, Thomas Gray, Vik Khullar, Rayan Mohamed‐Ahmed, Efstathios Papaefstathiou, Mauro Van den Ende, Alan Wein, Paul Abrams, and Dudley Robinson. 2025. “Is There Evidence of Diagnostic and Treatment Gaps for LUTS in Post‐menopausal Women with Genitourinary Syndrome of the Menopause? ICI‐RS 2025.” NEUROUROLOGY AND URODYNAMICS. doi:10.1002/nau.70173.
- Vancouver
- 1.Apostolidis A, Da Silva AS, Gray T, Khullar V, Mohamed‐Ahmed R, Papaefstathiou E, et al. Is there evidence of diagnostic and treatment gaps for LUTS in post‐menopausal women with genitourinary syndrome of the menopause? ICI‐RS 2025. NEUROUROLOGY AND URODYNAMICS. 2025;
- IEEE
- [1]A. Apostolidis et al., “Is there evidence of diagnostic and treatment gaps for LUTS in post‐menopausal women with genitourinary syndrome of the menopause? ICI‐RS 2025,” NEUROUROLOGY AND URODYNAMICS, 2025.
@article{01KAZX0T4RGQJQQJRMZAH6YYKV,
abstract = {{Aims
This report, from the International Consultation on Incontinence-Research Society, aims to evaluate the existing evidence and identify diagnostic and treatment gaps for Lower Urinary Tract Symptoms (LUTS) in post-menopausal women with Genitourinary Syndrome of Menopause (GSM).
Methods
An overview on the current literature, including pathophysiology, diagnosis and management of GSM associated LUTS, including incontinence, overactive bladder, underactive bladder and recurrent urinary tract infections (rUTIs).
Results
Significant gaps in the literature were identified. GSM is underdiagnosed and the interplay between hormonal changes in the postmenopausal period on LUTS remains poorly understood. Diagnostic methods for rUTIs lack sensitivity and the role of the urinary microbiome is emerging. Current treatments, including topical oestrogens and systemic hormone therapy, lack long-term efficacy data on LUTS. Evidence for regenerative medicine techniques remain limited by low-quality studies and short-term follow up.
Conclusion
There is lack of high-quality evidence, which hinders the optimal management of LUTS in post-menopausal women with GSM. The panel proposes targeted research questions, focusing on the hormonal impact on the lower urinary tract, advancing diagnostics and robust clinical trials for existing and novel therapies, to bridge current gaps in the literature and improve patient care.}},
author = {{Apostolidis, Apostolos and Da Silva, Ana Sofia and Gray, Thomas and Khullar, Vik and Mohamed‐Ahmed, Rayan and Papaefstathiou, Efstathios and Van den Ende, Mauro and Wein, Alan and Abrams, Paul and Robinson, Dudley}},
issn = {{0733-2467}},
journal = {{NEUROUROLOGY AND URODYNAMICS}},
language = {{eng}},
pages = {{8}},
title = {{Is there evidence of diagnostic and treatment gaps for LUTS in post‐menopausal women with genitourinary syndrome of the menopause? ICI‐RS 2025}},
url = {{http://doi.org/10.1002/nau.70173}},
year = {{2025}},
}
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