Risk assessment of pneumatic tube systems for in-hospital transportation of biotherapeutics
- Author
- Michaela Cohrs (UGent) , Paula E. Borgonje, Nele Clottens (UGent) , Pieter Ramaut (UGent) , Kevin Braeckmans (UGent) , Stefaan De Smedt (UGent) , Hristo Svilenov (UGent) and Tieneke Bauters (UGent)
- Organization
- Project
- Abstract
- Introduction : Use of Pneumatic tube systems (PTS's) poses a risk to inherently unstable protein therapeutics. Mechanical stress caused by those systems can lead to aggregation, compromising product safety and quality. However, PTS's are widely used in hospitals, and contradictory effects on protein stability have been reported. Methods : We studied whether mechanical stress levels differ between hospitals and routes, potentially leading to different findings regarding protein aggregation. By transporting a mechanical sensor on nine different PTS routes in seven different hospitals, we quantified the accelerations that protein therapeutics experience in a specific PTS setup. Results : It was found that the maximum acceleration within the different PTS setups was similar. However, transportation times differed up to 4-fold, leading to varying amounts of cumulative stress. Conclusion : The cumulative and maximum stress quantified can be compared to stress found in studies investigating protein stability, which justifies the usage of mechanical sensors for risk evaluation. The differences in stress found underscore the importance of evaluating handling practices individually in each hospital, for each therapeutic protein.
- Keywords
- Protein therapeutics, monoclonal antibodies, pneumatic tube systems, aggregation, in-use stability, PROTEIN FORMULATIONS, THERAPEUTIC PROTEINS, IV BAGS, PART 1, PARTICLES, IMMUNOGENICITY, AGGREGATION, PRODUCT
Downloads
-
Binder1.pdf
- full text (Accepted manuscript)
- |
- open access
- |
- |
- 563.58 KB
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01K94YE6JQ0R45S2P7P51C8ZKS
- MLA
- Cohrs, Michaela, et al. “Risk Assessment of Pneumatic Tube Systems for In-Hospital Transportation of Biotherapeutics.” JOURNAL OF ONCOLOGY PHARMACY PRACTICE, 2025, doi:10.1177/10781552251378729.
- APA
- Cohrs, M., Borgonje, P. E., Clottens, N., Ramaut, P., Braeckmans, K., De Smedt, S., … Bauters, T. (2025). Risk assessment of pneumatic tube systems for in-hospital transportation of biotherapeutics. JOURNAL OF ONCOLOGY PHARMACY PRACTICE. https://doi.org/10.1177/10781552251378729
- Chicago author-date
- Cohrs, Michaela, Paula E. Borgonje, Nele Clottens, Pieter Ramaut, Kevin Braeckmans, Stefaan De Smedt, Hristo Svilenov, and Tieneke Bauters. 2025. “Risk Assessment of Pneumatic Tube Systems for In-Hospital Transportation of Biotherapeutics.” JOURNAL OF ONCOLOGY PHARMACY PRACTICE. https://doi.org/10.1177/10781552251378729.
- Chicago author-date (all authors)
- Cohrs, Michaela, Paula E. Borgonje, Nele Clottens, Pieter Ramaut, Kevin Braeckmans, Stefaan De Smedt, Hristo Svilenov, and Tieneke Bauters. 2025. “Risk Assessment of Pneumatic Tube Systems for In-Hospital Transportation of Biotherapeutics.” JOURNAL OF ONCOLOGY PHARMACY PRACTICE. doi:10.1177/10781552251378729.
- Vancouver
- 1.Cohrs M, Borgonje PE, Clottens N, Ramaut P, Braeckmans K, De Smedt S, et al. Risk assessment of pneumatic tube systems for in-hospital transportation of biotherapeutics. JOURNAL OF ONCOLOGY PHARMACY PRACTICE. 2025;
- IEEE
- [1]M. Cohrs et al., “Risk assessment of pneumatic tube systems for in-hospital transportation of biotherapeutics,” JOURNAL OF ONCOLOGY PHARMACY PRACTICE, 2025.
@article{01K94YE6JQ0R45S2P7P51C8ZKS,
abstract = {{Introduction :
Use of Pneumatic tube systems (PTS's) poses a risk to inherently unstable protein therapeutics. Mechanical stress caused by those systems can lead to aggregation, compromising product safety and quality. However, PTS's are widely used in hospitals, and contradictory effects on protein stability have been reported.
Methods :
We studied whether mechanical stress levels differ between hospitals and routes, potentially leading to different findings regarding protein aggregation. By transporting a mechanical sensor on nine different PTS routes in seven different hospitals, we quantified the accelerations that protein therapeutics experience in a specific PTS setup.
Results :
It was found that the maximum acceleration within the different PTS setups was similar. However, transportation times differed up to 4-fold, leading to varying amounts of cumulative stress.
Conclusion :
The cumulative and maximum stress quantified can be compared to stress found in studies investigating protein stability, which justifies the usage of mechanical sensors for risk evaluation. The differences in stress found underscore the importance of evaluating handling practices individually in each hospital, for each therapeutic protein.}},
author = {{Cohrs, Michaela and Borgonje, Paula E. and Clottens, Nele and Ramaut, Pieter and Braeckmans, Kevin and De Smedt, Stefaan and Svilenov, Hristo and Bauters, Tieneke}},
issn = {{1078-1552}},
journal = {{JOURNAL OF ONCOLOGY PHARMACY PRACTICE}},
keywords = {{Protein therapeutics,monoclonal antibodies,pneumatic tube systems,aggregation,in-use stability,PROTEIN FORMULATIONS,THERAPEUTIC PROTEINS,IV BAGS,PART 1,PARTICLES,IMMUNOGENICITY,AGGREGATION,PRODUCT}},
language = {{eng}},
pages = {{10}},
title = {{Risk assessment of pneumatic tube systems for in-hospital transportation of biotherapeutics}},
url = {{http://doi.org/10.1177/10781552251378729}},
year = {{2025}},
}
- Altmetric
- View in Altmetric
- Web of Science
- Times cited: