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Assessing the link between cerebellar volume and cognitive function in Alzheimer’s disease : a pilot study

Deborah Van Rossem, Gert-Jan Allemeersch, Nuno Barros, Joke Temmerman, Marijke Desmet, Ilka Ringoot, Annemie Ribbens, Veronique Michiels, Johan De Mey, Chris Baeken (UGent) , et al.
(2025) SCIENTIFIC REPORTS. 15(1).
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Abstract
The cerebellum, long recognized for its role in motor functions, has become increasingly acknowledged for its involvement in a broader spectrum of cognitive functions. Given the cerebellum's strong neuronal connections with cerebral regions affected by neurodegenerative diseases, this study investigated the cerebellar contribution to cognitive decline in Alzheimer's disease (AD). This study retrospectively analysed 127 individuals with subjective cognitive decline (SCD, n = 46), mild cognitive impairment due to AD (MCI, n = 24), and AD dementia (ADD, n = 57). Grey and white matter volumes of the whole cerebellum and its lobules were examined and correlated with cognitive scores. Significant grey matter atrophy was observed in posterior cerebellar regions (including crus II, lobule VIIa, VIIIa, VIIIb, and X), particularly between SCD and ADD, but not between MCI and ADD. Additionally, cerebellar volume positively correlated with cognitive function in SCD, MCI and ADD. These findings support the hypothesis that cerebellar atrophy is associated with cognitive symptoms of neurodegenerative diseases like AD.
Keywords
Alzheimer's disease (AD), Brain volume, Atrophy, Cerebellum, Cognitive decline, WORKING-MEMORY, RECOMMENDATIONS, IMPAIRMENT, DIAGNOSIS, DEMENTIA, PATTERNS, STATE

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MLA
Van Rossem, Deborah, et al. “Assessing the Link between Cerebellar Volume and Cognitive Function in Alzheimer’s Disease : A Pilot Study.” SCIENTIFIC REPORTS, vol. 15, no. 1, 2025, doi:10.1038/s41598-025-12975-8.
APA
Van Rossem, D., Allemeersch, G.-J., Barros, N., Temmerman, J., Desmet, M., Ringoot, I., … De Witte, S. (2025). Assessing the link between cerebellar volume and cognitive function in Alzheimer’s disease : a pilot study. SCIENTIFIC REPORTS, 15(1). https://doi.org/10.1038/s41598-025-12975-8
Chicago author-date
Van Rossem, Deborah, Gert-Jan Allemeersch, Nuno Barros, Joke Temmerman, Marijke Desmet, Ilka Ringoot, Annemie Ribbens, et al. 2025. “Assessing the Link between Cerebellar Volume and Cognitive Function in Alzheimer’s Disease : A Pilot Study.” SCIENTIFIC REPORTS 15 (1). https://doi.org/10.1038/s41598-025-12975-8.
Chicago author-date (all authors)
Van Rossem, Deborah, Gert-Jan Allemeersch, Nuno Barros, Joke Temmerman, Marijke Desmet, Ilka Ringoot, Annemie Ribbens, Veronique Michiels, Johan De Mey, Chris Baeken, Sebastiaan Engelborghs, and Sara De Witte. 2025. “Assessing the Link between Cerebellar Volume and Cognitive Function in Alzheimer’s Disease : A Pilot Study.” SCIENTIFIC REPORTS 15 (1). doi:10.1038/s41598-025-12975-8.
Vancouver
1.
Van Rossem D, Allemeersch G-J, Barros N, Temmerman J, Desmet M, Ringoot I, et al. Assessing the link between cerebellar volume and cognitive function in Alzheimer’s disease : a pilot study. SCIENTIFIC REPORTS. 2025;15(1).
IEEE
[1]
D. Van Rossem et al., “Assessing the link between cerebellar volume and cognitive function in Alzheimer’s disease : a pilot study,” SCIENTIFIC REPORTS, vol. 15, no. 1, 2025.
@article{01K7NZERW7QNRVY5ZJZ5M4F944,
  abstract     = {{The cerebellum, long recognized for its role in motor functions, has become increasingly acknowledged for its involvement in a broader spectrum of cognitive functions. Given the cerebellum's strong neuronal connections with cerebral regions affected by neurodegenerative diseases, this study investigated the cerebellar contribution to cognitive decline in Alzheimer's disease (AD). This study retrospectively analysed 127 individuals with subjective cognitive decline (SCD, n = 46), mild cognitive impairment due to AD (MCI, n = 24), and AD dementia (ADD, n = 57). Grey and white matter volumes of the whole cerebellum and its lobules were examined and correlated with cognitive scores. Significant grey matter atrophy was observed in posterior cerebellar regions (including crus II, lobule VIIa, VIIIa, VIIIb, and X), particularly between SCD and ADD, but not between MCI and ADD. Additionally, cerebellar volume positively correlated with cognitive function in SCD, MCI and ADD. These findings support the hypothesis that cerebellar atrophy is associated with cognitive symptoms of neurodegenerative diseases like AD.}},
  articleno    = {{32943}},
  author       = {{Van Rossem, Deborah and Allemeersch, Gert-Jan and Barros, Nuno and Temmerman, Joke and Desmet, Marijke and Ringoot, Ilka and Ribbens, Annemie and Michiels, Veronique and De Mey, Johan and Baeken, Chris and Engelborghs, Sebastiaan and De Witte, Sara}},
  issn         = {{2045-2322}},
  journal      = {{SCIENTIFIC REPORTS}},
  keywords     = {{Alzheimer's disease (AD),Brain volume,Atrophy,Cerebellum,Cognitive decline,WORKING-MEMORY,RECOMMENDATIONS,IMPAIRMENT,DIAGNOSIS,DEMENTIA,PATTERNS,STATE}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{12}},
  title        = {{Assessing the link between cerebellar volume and cognitive function in Alzheimer’s disease : a pilot study}},
  url          = {{http://doi.org/10.1038/s41598-025-12975-8}},
  volume       = {{15}},
  year         = {{2025}},
}
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