Academic Bibliography

 Search 200 years of publications by Ghent University researchers.
Advanced search
1 file | 3.18 MB
Add to list
  1. Search results
  2. VSIG4-expressing macrophages contribu...

VSIG4-expressing macrophages contribute to antiparasitic and antimetastatic responses in the peritoneal cavity

Els Lebegge, Daliya Kancheva, Jolien Van Craenenbroeck, Sam Ernst (UGent) , Pauline M. R. Bardet, Aarushi A. Caro, Mate Kiss, Neema Ahishakiye Jumapili, Romina Mora Barthelmess, Maida Zivalj, et al.
(2025) EUROPEAN JOURNAL OF IMMUNOLOGY. 55(5).
Author
Organization
Abstract
Large peritoneal macrophages (LPMs) play a role as gatekeepers of peritoneal homeostasis by providing a first line of defense against pathogens. A third of the LPMs express the surface receptor VSIG4, but it is unclear whether these cells differ from their VSIG4-negative counterparts and perform dedicated functions. We demonstrate that VSIG4+, but not VSIG4-, LPMs are in the majority derived from embryonal precursors, and their occurrence is largely independent of sex and microbiota but increases with age. Although their transcriptome and surface proteome are indistinguishable from VSIG4- LPMs at steady-state, VSIG4+ LPMs are superior in phagocytosing S. aureus bioparticles and colorectal carcinoma (CRC) cells. Anti-VSIG4 nanobody constructs that are ADCC-enabled allowed a selective elimination of the VSIG4+ LPM subset without affecting overall LPM abundance. This strategy uncovered a role for VSIG4+ LPMs in lowering the first peak of parasitemia in a Trypanosoma brucei brucei infection model and in reducing CRC outgrowth in the peritoneal cavity, a prime metastatic site in CRC patients. Altogether, our data uncover a protective role for VSIG4+ LPMs in infectious and oncological diseases in the peritoneal cavity.
Keywords
colorectal cancer metastasis, large peritoneal macrophage, <italic>Trypanosoma brucei</italic> brucei infection, VSIG4, TUMOR MICROENVIRONMENT, CELL-ACTIVATION, RECEPTOR, CRIG

Downloads

  • Download
    5322 25Lebegge.pdf
    • full text (Published version)
    • |
    • open access
    • |
    • PDF
    • |
    • 3.18 MB

Citation

Please use this url to cite or link to this publication:

MLA
Lebegge, Els, et al. “VSIG4-Expressing Macrophages Contribute to Antiparasitic and Antimetastatic Responses in the Peritoneal Cavity.” EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 55, no. 5, 2025, doi:10.1002/eji.202551804.
APA
Lebegge, E., Kancheva, D., Van Craenenbroeck, J., Ernst, S., Bardet, P. M. R., Caro, A. A., … Van Ginderachter, J. (2025). VSIG4-expressing macrophages contribute to antiparasitic and antimetastatic responses in the peritoneal cavity. EUROPEAN JOURNAL OF IMMUNOLOGY, 55(5). https://doi.org/10.1002/eji.202551804
Chicago author-date
Lebegge, Els, Daliya Kancheva, Jolien Van Craenenbroeck, Sam Ernst, Pauline M. R. Bardet, Aarushi A. Caro, Mate Kiss, et al. 2025. “VSIG4-Expressing Macrophages Contribute to Antiparasitic and Antimetastatic Responses in the Peritoneal Cavity.” EUROPEAN JOURNAL OF IMMUNOLOGY 55 (5). https://doi.org/10.1002/eji.202551804.
Chicago author-date (all authors)
Lebegge, Els, Daliya Kancheva, Jolien Van Craenenbroeck, Sam Ernst, Pauline M. R. Bardet, Aarushi A. Caro, Mate Kiss, Neema Ahishakiye Jumapili, Romina Mora Barthelmess, Maida Zivalj, Naela Assaf, Leen Ali, Yvon Elkrim, Jesse Demuytere, Jan De Jonge, Geert Raes, Eva Hadadi, Nick Devoogdt, Cecile Vincke, Kiavash Mohavedi, Lars Vereecke, Wim Ceelen, Benoit Stijlemans, Damya Laoui, Sana M. Arnouk, and Jo Van Ginderachter. 2025. “VSIG4-Expressing Macrophages Contribute to Antiparasitic and Antimetastatic Responses in the Peritoneal Cavity.” EUROPEAN JOURNAL OF IMMUNOLOGY 55 (5). doi:10.1002/eji.202551804.
Vancouver
1.
Lebegge E, Kancheva D, Van Craenenbroeck J, Ernst S, Bardet PMR, Caro AA, et al. VSIG4-expressing macrophages contribute to antiparasitic and antimetastatic responses in the peritoneal cavity. EUROPEAN JOURNAL OF IMMUNOLOGY. 2025;55(5).
IEEE
[1]
E. Lebegge et al., “VSIG4-expressing macrophages contribute to antiparasitic and antimetastatic responses in the peritoneal cavity,” EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 55, no. 5, 2025.
@article{01K0Y5S775HBSXGR0B4FKN1XXM,
  abstract     = {{Large peritoneal macrophages (LPMs) play a role as gatekeepers of peritoneal homeostasis by providing a first line of defense against pathogens. A third of the LPMs express the surface receptor VSIG4, but it is unclear whether these cells differ from their VSIG4-negative counterparts and perform dedicated functions. We demonstrate that VSIG4+, but not VSIG4-, LPMs are in the majority derived from embryonal precursors, and their occurrence is largely independent of sex and microbiota but increases with age. Although their transcriptome and surface proteome are indistinguishable from VSIG4- LPMs at steady-state, VSIG4+ LPMs are superior in phagocytosing S. aureus bioparticles and colorectal carcinoma (CRC) cells. Anti-VSIG4 nanobody constructs that are ADCC-enabled allowed a selective elimination of the VSIG4+ LPM subset without affecting overall LPM abundance. This strategy uncovered a role for VSIG4+ LPMs in lowering the first peak of parasitemia in a Trypanosoma brucei brucei infection model and in reducing CRC outgrowth in the peritoneal cavity, a prime metastatic site in CRC patients. Altogether, our data uncover a protective role for VSIG4+ LPMs in infectious and oncological diseases in the peritoneal cavity.}},
  articleno    = {{e202551804}},
  author       = {{Lebegge, Els and Kancheva, Daliya and Van Craenenbroeck, Jolien and Ernst, Sam and Bardet, Pauline M. R. and Caro, Aarushi A. and Kiss, Mate and Jumapili, Neema Ahishakiye and Barthelmess, Romina Mora and Zivalj, Maida and Assaf, Naela and Ali, Leen and Elkrim, Yvon and Demuytere, Jesse and De Jonge, Jan and Raes, Geert and Hadadi, Eva and Devoogdt, Nick and Vincke, Cecile and Mohavedi, Kiavash and Vereecke, Lars and Ceelen, Wim and Stijlemans, Benoit and Laoui, Damya and Arnouk, Sana M. and Van Ginderachter, Jo}},
  issn         = {{0014-2980}},
  journal      = {{EUROPEAN JOURNAL OF IMMUNOLOGY}},
  keywords     = {{colorectal cancer metastasis,large peritoneal macrophage,<italic>Trypanosoma brucei</italic> brucei infection,VSIG4,TUMOR MICROENVIRONMENT,CELL-ACTIVATION,RECEPTOR,CRIG}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{11}},
  title        = {{VSIG4-expressing macrophages contribute to antiparasitic and antimetastatic responses in the peritoneal cavity}},
  url          = {{http://doi.org/10.1002/eji.202551804}},
  volume       = {{55}},
  year         = {{2025}},
}
Altmetric
View in Altmetric
Web of Science
Times cited: