@article{01JZ7QAWFER8K4PPYRH5730YTZ,
  abstract     = {{Background The coronavirus disease 2019 (COVID-19) pandemic has had a profound global impact. Therapeutic strategies to bridge the crucial "lockdown" timespan between the emergence of a new virus and vaccine rollout are needed.Methods We recently demonstrated that intranasal administration of COVID-19 convalescent plasma (CCP) in sentinel hamsters can limit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission from acutely infected index littermates. The current study investigates if functional immunity develops during intranasal prophylaxis in the same model.Results Lung tissue was free from infectious virus and pneumonia in sentinel hamsters after intranasal CCP prophylaxis, unlike those receiving nonimmune control plasma. However, throat swabs from both groups contained viral RNA similar to intentionally infected index littermates. Anti-receptor binding domain (RBD) antibodies were detected in plasma from both sentinel groups 2 days after it showed in index littermates. This immune response was functional because all sentinel hamsters were protected from reinfection by the same viral strain.Conclusions Our findings demonstrate that intranasal CCP prophylaxis prevents lung disease in hamsters by restraining the infection to the upper respiratory tract, while still promoting a functional humoral immune response that protects against reinfection.

Intranasal COVID-19 convalescent plasma prevents severe disease in hamsters and protects against reinfection.}},
  author       = {{Verbrugghe, Caro and Abdelnabi, Rana and Maes, Tania and Coelmont, Lotte and Weynand, Birgit and Vandekerckhove, Philippe and Neyts, Johan and Feys, Hendrik and Wouters, Elise}},
  issn         = {{0022-1899}},
  journal      = {{JOURNAL OF INFECTIOUS DISEASES}},
  keywords     = {{COVID-19,convalescent plasma,SARS-CoV-2,prophylaxis,intranasal}},
  language     = {{eng}},
  pages        = {{10}},
  title        = {{Functional humoral response during intranasal convalescent plasma prophylaxis for severe acute respiratory syndrome coronavirus 2}},
  url          = {{http://doi.org/10.1093/infdis/jiaf273}},
  year         = {{2025}},
}

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