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Chemo-photothermal therapy of chitosan/gold nanorod clusters for antibacterial treatment against the infection of planktonic and biofilm MRSA

Nirmal Gobichettipalayam Rajendran (UGent) , Zih-Chan Lin, Tai-Sheng Chiu, Ahmed Alalaiwe, Chia-Chih Liao and Jia-You Fang
(2024) INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 268(Part 1).
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Abstract
Bacterial infections trigger inflammation and impede the closure of skin wounds. The misuse of antibiotics exacerbates skin infections by generating multidrug-resistant bacteria. In this study, we developed chemophotothermal therapy (chemo-PTT) based on near-infrared (NIR)-irradiated chitosan/gold nanorod (GNR) clusters as anti-methicillin-resistant Staphylococcus aureus (MRSA) agents. The nanocomposites exhibited an average size of 223 nm with a surface charge of 36 mV. These plasmonic nanocomposites demonstrated ondemand and rapid hyperthermal action under NIR. The combined effect of positive charge and PTT by NIRirradiated nanocomposites resulted in a remarkable inhibition rate of 96 % against planktonic MRSA, indicating a synergistic activity compared to chitosan nanoparticles or GNR alone. The nanocomposites easily penetrated the biofilm matrix. The combination of chemical and photothermal treatments by NIR-stimulated clusters significantly damaged the biofilm structure, eradicating MRSA inside the biomass. NIR-irradiated chitosan/GNR clusters increased the skin temperature of mice by 13 degrees C. The plasmonic nanocomposites induced negligible skin irritation in vivo. In summary, this novel nanosystem demonstrated potent antibacterial effects against planktonic and biofilm MRSA, showcasing the possible efficacy in treating skin infections.
Keywords
Chitosan, Gold nanorod, Methicillin-resistant Staphylococcus aureus, Biofilm, Skin, Photothermal therapy

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MLA
Gobichettipalayam Rajendran, Nirmal, et al. “Chemo-Photothermal Therapy of Chitosan/Gold Nanorod Clusters for Antibacterial Treatment against the Infection of Planktonic and Biofilm MRSA.” INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, vol. 268, no. Part 1, 2024, doi:10.1016/j.ijbiomac.2024.131673.
APA
Gobichettipalayam Rajendran, N., Lin, Z.-C., Chiu, T.-S., Alalaiwe, A., Liao, C.-C., & Fang, J.-Y. (2024). Chemo-photothermal therapy of chitosan/gold nanorod clusters for antibacterial treatment against the infection of planktonic and biofilm MRSA. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 268(Part 1). https://doi.org/10.1016/j.ijbiomac.2024.131673
Chicago author-date
Gobichettipalayam Rajendran, Nirmal, Zih-Chan Lin, Tai-Sheng Chiu, Ahmed Alalaiwe, Chia-Chih Liao, and Jia-You Fang. 2024. “Chemo-Photothermal Therapy of Chitosan/Gold Nanorod Clusters for Antibacterial Treatment against the Infection of Planktonic and Biofilm MRSA.” INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 268 (Part 1). https://doi.org/10.1016/j.ijbiomac.2024.131673.
Chicago author-date (all authors)
Gobichettipalayam Rajendran, Nirmal, Zih-Chan Lin, Tai-Sheng Chiu, Ahmed Alalaiwe, Chia-Chih Liao, and Jia-You Fang. 2024. “Chemo-Photothermal Therapy of Chitosan/Gold Nanorod Clusters for Antibacterial Treatment against the Infection of Planktonic and Biofilm MRSA.” INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 268 (Part 1). doi:10.1016/j.ijbiomac.2024.131673.
Vancouver
1.
Gobichettipalayam Rajendran N, Lin Z-C, Chiu T-S, Alalaiwe A, Liao C-C, Fang J-Y. Chemo-photothermal therapy of chitosan/gold nanorod clusters for antibacterial treatment against the infection of planktonic and biofilm MRSA. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2024;268(Part 1).
IEEE
[1]
N. Gobichettipalayam Rajendran, Z.-C. Lin, T.-S. Chiu, A. Alalaiwe, C.-C. Liao, and J.-Y. Fang, “Chemo-photothermal therapy of chitosan/gold nanorod clusters for antibacterial treatment against the infection of planktonic and biofilm MRSA,” INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, vol. 268, no. Part 1, 2024.
@article{01JYKDE33FN17KHNTYX9SWGDJR,
  abstract     = {{Bacterial infections trigger inflammation and impede the closure of skin wounds. The misuse of antibiotics exacerbates skin infections by generating multidrug-resistant bacteria. In this study, we developed chemophotothermal therapy (chemo-PTT) based on near-infrared (NIR)-irradiated chitosan/gold nanorod (GNR) clusters as anti-methicillin-resistant Staphylococcus aureus (MRSA) agents. The nanocomposites exhibited an average size of 223 nm with a surface charge of 36 mV. These plasmonic nanocomposites demonstrated ondemand and rapid hyperthermal action under NIR. The combined effect of positive charge and PTT by NIRirradiated nanocomposites resulted in a remarkable inhibition rate of 96 % against planktonic MRSA, indicating a synergistic activity compared to chitosan nanoparticles or GNR alone. The nanocomposites easily penetrated the biofilm matrix. The combination of chemical and photothermal treatments by NIR-stimulated clusters significantly damaged the biofilm structure, eradicating MRSA inside the biomass. NIR-irradiated chitosan/GNR clusters increased the skin temperature of mice by 13 degrees C. The plasmonic nanocomposites induced negligible skin irritation in vivo. In summary, this novel nanosystem demonstrated potent antibacterial effects against planktonic and biofilm MRSA, showcasing the possible efficacy in treating skin infections.}},
  articleno    = {{131673}},
  author       = {{Gobichettipalayam Rajendran, Nirmal and Lin, Zih-Chan and Chiu, Tai-Sheng and Alalaiwe, Ahmed and Liao, Chia-Chih and Fang, Jia-You}},
  issn         = {{0141-8130}},
  journal      = {{INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES}},
  keywords     = {{Chitosan,Gold nanorod,Methicillin-resistant Staphylococcus aureus,Biofilm,Skin,Photothermal therapy}},
  language     = {{eng}},
  number       = {{Part 1}},
  pages        = {{11}},
  title        = {{Chemo-photothermal therapy of chitosan/gold nanorod clusters for antibacterial treatment against the infection of planktonic and biofilm MRSA}},
  url          = {{http://doi.org/10.1016/j.ijbiomac.2024.131673}},
  volume       = {{268}},
  year         = {{2024}},
}
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