- Author
- Lara Hogeveen (UGent) , Paul Boon (UGent) , Ann Mertens (UGent) , Lennart Verhagen and Kristl Vonck (UGent)
- Organization
- Abstract
- Up to 40 % of people with epilepsy (PwE) suffer from drug-resistant epilepsy (DRE). Despite the approval of novel anti-seizure medication (ASM), a significant treatment gap persists, emphasizing the need for alternative therapies. Transcranial delivery of ultrasound waves or focused ultrasound (FUS) is a promising novel non-invasive technique for PwE, capable of targeting deep brain regions at millimeter resolution. High-intensity Focused Ultrasound (HiFU) is used for focal ablation and Low-intensity Focused Ultrasound (LiFU) for non-invasive neuromodulation. Transcranial delivery of ultrasound waves can also be used for targeted drug delivery by either transiently opening the blood-brain barrier (BBB), or increasing focal drug uptake without BBB opening, through mechanisms such as reducing plasma protein binding or drug uncaging. An update on the current state of the art of LiFU, HiFU and ultrasound waves for targeted drug delivery in epilepsy is timely in view of recently performed clinical trials. We provide scientific background and discuss its added value for PwE. The limitations are addressed, and the technique is discussed in the context of currently available therapies for DRE.
- Keywords
- Low intensity transcranial ultrasound, High intensity transcranial ultrasound, Drug resistant epilepsy, Non-invasive, Neuromodulation, Ablation, BLOOD-BRAIN-BARRIER, DRUG-RESISTANT EPILEPSY, NEUROMODULATION, STIMULATION, SURGERY, DELIVERY, OUTCOMES, DISEASE, BINDING, LESIONS
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01JWAV9P04N4X5MSH2S8Q4055A
- MLA
- Hogeveen, Lara, et al. “Therapeutic Use of Transcranial Ultrasound for Epilepsy : A Review.” HELIYON, vol. 11, no. 5, 2025, doi:10.1016/j.heliyon.2025.e43001.
- APA
- Hogeveen, L., Boon, P., Mertens, A., Verhagen, L., & Vonck, K. (2025). Therapeutic use of transcranial ultrasound for epilepsy : a review. HELIYON, 11(5). https://doi.org/10.1016/j.heliyon.2025.e43001
- Chicago author-date
- Hogeveen, Lara, Paul Boon, Ann Mertens, Lennart Verhagen, and Kristl Vonck. 2025. “Therapeutic Use of Transcranial Ultrasound for Epilepsy : A Review.” HELIYON 11 (5). https://doi.org/10.1016/j.heliyon.2025.e43001.
- Chicago author-date (all authors)
- Hogeveen, Lara, Paul Boon, Ann Mertens, Lennart Verhagen, and Kristl Vonck. 2025. “Therapeutic Use of Transcranial Ultrasound for Epilepsy : A Review.” HELIYON 11 (5). doi:10.1016/j.heliyon.2025.e43001.
- Vancouver
- 1.Hogeveen L, Boon P, Mertens A, Verhagen L, Vonck K. Therapeutic use of transcranial ultrasound for epilepsy : a review. HELIYON. 2025;11(5).
- IEEE
- [1]L. Hogeveen, P. Boon, A. Mertens, L. Verhagen, and K. Vonck, “Therapeutic use of transcranial ultrasound for epilepsy : a review,” HELIYON, vol. 11, no. 5, 2025.
@article{01JWAV9P04N4X5MSH2S8Q4055A,
abstract = {{Up to 40 % of people with epilepsy (PwE) suffer from drug-resistant epilepsy (DRE). Despite the approval of novel anti-seizure medication (ASM), a significant treatment gap persists, emphasizing the need for alternative therapies. Transcranial delivery of ultrasound waves or focused ultrasound (FUS) is a promising novel non-invasive technique for PwE, capable of targeting deep brain regions at millimeter resolution. High-intensity Focused Ultrasound (HiFU) is used for focal ablation and Low-intensity Focused Ultrasound (LiFU) for non-invasive neuromodulation. Transcranial delivery of ultrasound waves can also be used for targeted drug delivery by either transiently opening the blood-brain barrier (BBB), or increasing focal drug uptake without BBB opening, through mechanisms such as reducing plasma protein binding or drug uncaging. An update on the current state of the art of LiFU, HiFU and ultrasound waves for targeted drug delivery in epilepsy is timely in view of recently performed clinical trials. We provide scientific background and discuss its added value for PwE. The limitations are addressed, and the technique is discussed in the context of currently available therapies for DRE.}},
articleno = {{e43001}},
author = {{Hogeveen, Lara and Boon, Paul and Mertens, Ann and Verhagen, Lennart and Vonck, Kristl}},
issn = {{2405-8440}},
journal = {{HELIYON}},
keywords = {{Low intensity transcranial ultrasound,High intensity transcranial ultrasound,Drug resistant epilepsy,Non-invasive,Neuromodulation,Ablation,BLOOD-BRAIN-BARRIER,DRUG-RESISTANT EPILEPSY,NEUROMODULATION,STIMULATION,SURGERY,DELIVERY,OUTCOMES,DISEASE,BINDING,LESIONS}},
language = {{eng}},
number = {{5}},
pages = {{14}},
title = {{Therapeutic use of transcranial ultrasound for epilepsy : a review}},
url = {{http://doi.org/10.1016/j.heliyon.2025.e43001}},
volume = {{11}},
year = {{2025}},
}
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