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Genome-wide association study to identify genetic markers associated with Campylobacter jejuni motility

Irene Ortega Sanz (UGent) , Jordi Rovira, Gregoria Megías, María Dolores Rivero-Pérez and Beatriz Melero
(2025) MICROBIAL PATHOGENESIS. 205.
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Abstract
The ability of Campylobacter jejuni to survive and persist under harsh conditions is linked to the presence of flagella. This structure promotes the motility of the bacteria towards their optimum environment. The aim of this study was to examine the genetic basis for motility within 136 C. jejuni isolates through two different Genome-Wide Association Studies, gene presence/absence and Single Nucleotide Polymorphisms (SNPs). The motility phenotype was widely distributed across the phylogeny with large intra-lineage swarming performance variabilities. Accessory genes significantly associated with motility were found in four key genomic regions. One of these regions affected the Cj0727-Cj0733 operon, that encodes a putative ABC transporter system for phosphate uptake, while other influenced the capsule biosynthesis locus. Multiple SNPs mostly linked to increased motility were also discovered in clusters of genes, with special relevance to transport and membrane proteins. Therefore, the capsule and membrane composition might influence nutrient transfer, further impacting the protonmotive force that drives flagellar motor rotation in C. jejuni. The study provides novel genetic markers with a potential role in the motility phenotype of the pathogen.
Keywords
Genomics, GWAS, Phenotype, Pangenome, SNP, Genetic marker, Bacterial GWAS, IDENTIFICATION, VIRULENCE, SURVIVAL, GROWTH

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MLA
Ortega Sanz, Irene, et al. “Genome-Wide Association Study to Identify Genetic Markers Associated with Campylobacter Jejuni Motility.” MICROBIAL PATHOGENESIS, vol. 205, 2025, doi:10.1016/j.micpath.2025.107657.
APA
Ortega Sanz, I., Rovira, J., Megías, G., Rivero-Pérez, M. D., & Melero, B. (2025). Genome-wide association study to identify genetic markers associated with Campylobacter jejuni motility. MICROBIAL PATHOGENESIS, 205. https://doi.org/10.1016/j.micpath.2025.107657
Chicago author-date
Ortega Sanz, Irene, Jordi Rovira, Gregoria Megías, María Dolores Rivero-Pérez, and Beatriz Melero. 2025. “Genome-Wide Association Study to Identify Genetic Markers Associated with Campylobacter Jejuni Motility.” MICROBIAL PATHOGENESIS 205. https://doi.org/10.1016/j.micpath.2025.107657.
Chicago author-date (all authors)
Ortega Sanz, Irene, Jordi Rovira, Gregoria Megías, María Dolores Rivero-Pérez, and Beatriz Melero. 2025. “Genome-Wide Association Study to Identify Genetic Markers Associated with Campylobacter Jejuni Motility.” MICROBIAL PATHOGENESIS 205. doi:10.1016/j.micpath.2025.107657.
Vancouver
1.
Ortega Sanz I, Rovira J, Megías G, Rivero-Pérez MD, Melero B. Genome-wide association study to identify genetic markers associated with Campylobacter jejuni motility. MICROBIAL PATHOGENESIS. 2025;205.
IEEE
[1]
I. Ortega Sanz, J. Rovira, G. Megías, M. D. Rivero-Pérez, and B. Melero, “Genome-wide association study to identify genetic markers associated with Campylobacter jejuni motility,” MICROBIAL PATHOGENESIS, vol. 205, 2025.
@article{01JV1JHYW8VH93SDCP8YD0Y87C,
  abstract     = {{The ability of Campylobacter jejuni to survive and persist under harsh conditions is linked to the presence of flagella. This structure promotes the motility of the bacteria towards their optimum environment. The aim of this study was to examine the genetic basis for motility within 136 C. jejuni isolates through two different Genome-Wide Association Studies, gene presence/absence and Single Nucleotide Polymorphisms (SNPs). The motility phenotype was widely distributed across the phylogeny with large intra-lineage swarming performance variabilities. Accessory genes significantly associated with motility were found in four key genomic regions. One of these regions affected the Cj0727-Cj0733 operon, that encodes a putative ABC transporter system for phosphate uptake, while other influenced the capsule biosynthesis locus. Multiple SNPs mostly linked to increased motility were also discovered in clusters of genes, with special relevance to transport and membrane proteins. Therefore, the capsule and membrane composition might influence nutrient transfer, further impacting the protonmotive force that drives flagellar motor rotation in C. jejuni. The study provides novel genetic markers with a potential role in the motility phenotype of the pathogen.}},
  articleno    = {{107657}},
  author       = {{Ortega Sanz, Irene and Rovira, Jordi and Megías, Gregoria and Rivero-Pérez, María Dolores and Melero, Beatriz}},
  issn         = {{0882-4010}},
  journal      = {{MICROBIAL PATHOGENESIS}},
  keywords     = {{Genomics,GWAS,Phenotype,Pangenome,SNP,Genetic marker,Bacterial GWAS,IDENTIFICATION,VIRULENCE,SURVIVAL,GROWTH}},
  language     = {{eng}},
  pages        = {{12}},
  title        = {{Genome-wide association study to identify genetic markers associated with Campylobacter jejuni motility}},
  url          = {{http://doi.org/10.1016/j.micpath.2025.107657}},
  volume       = {{205}},
  year         = {{2025}},
}
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