@article{01JQNPTCN6E50BGWQ1ACYJQXPY,
  abstract     = {{Alterations in the prostate cancer (PCa) N-glycome have gained attention as a potential biomarker. This comprehensive review explores the diversity of N-glycosylation patterns observed in PCa-related cell lines, tissue, serum and urine, focusing on prostate-specific antigen (PSA) and the total pool of glycoproteins. Within the context of PCa, altered N-glycosylation patterns are a mechanism of immune escape and a disruption in normal glycoprotein distribution and trafficking. Glycoproteins with PCa-induced N-glycosylation patterns tend to accumulate in prostate tissue and the bloodstream, thereby diminishing N-glycan proportions in urine. Based on literary observations, aberrations in N-glycan branching are probably a characteristic of metabolic reprogramming and (chronic) inflammation. Changes in (core) fucosylation, specific N-glycosylation structures (such as N, N '-diacetyllactosamine) and high-mannose glycans otherwise are more likely indicators of cancer development and progression. Further investigation into these PCa-specific alterations holds promise in the discovery of new diagnostic, prognostic and response prediction biomarkers in PCa.}},
  articleno    = {{189239}},
  author       = {{Eggermont, Lissa and Lumen, Nicolaas and Van Praet, Charles and Delanghe, Joris and Rottey, Sylvie and Vermassen, Tijl}},
  issn         = {{0304-419X}},
  journal      = {{BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER}},
  keywords     = {{Prostate cancer,N-linked glycosylation,Biomarker,Diagnosis,Prognosis,ABERRANT GLYCOSYLATION,ALTERED GLYCOSYLATION,POTENTIAL BIOMARKERS,PSA GLYCOSYLATION,LINKED GLYCANS,ANTIGEN PSA,DIAGNOSIS,LECTIN,SIALYLATION,SPECIFICITY}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{15}},
  title        = {{A comprehensive view of N-glycosylation as clinical biomarker in prostate cancer}},
  url          = {{http://doi.org/10.1016/j.bbcan.2024.189239}},
  volume       = {{1880}},
  year         = {{2025}},
}

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