@inproceedings{01JQ65K6HK1WKM0Q9423K36NHD,
  abstract     = {{With the expanding population of older adults and their unique care profile, there is an urgent need for better
clarity on fluoroquinolone pharmacokinetics (PK) and dosing. Older adults are often excluded from clinical
trials. This study aims to bridge that gap by summarizing existing literature on fluoroquinolone PK in older
adults and exploring potential covariates that influence PK and target attainment. This is a systematic
review using four online databases. The articles were screened in Rayyan and EndNote and a table was
made for data extraction. In this review, 44 articles were included, covering nine fluoroquinolones. These
studies examined oral and intravenous routes. Comparisons with younger control groups often indicated a
higher AUC, Cmax, T½ and lower CL and Vd in older adults. Renal function was observed to be a covariate
of CL in 18.8% of the articles. 72.7% reported dosing recommendations. Target attainment was addressed
in 29.5% of studies. This review highlighted the limited research on the PK and target attainment in older
adults. Small sample sizes, lack of comparator groups, and insufficient focus on older subpopulations and
renal function impact the reliability of these findings. Renal function seemed critical for evidence-based
dosing. There is an urgent need for more research on fluoroquinolone PK, such as popPK studies and Monte
Carlo-simulations, to provide dosing recommendations.}},
  author       = {{De Petter, Cristina and De Ryck, Stef and De Clercq, Arnaud and Vervalcke, Jeroen and De Cock, Pieter and Petrovic, Mirko and Desmet, Tania and De Paepe, Peter}},
  booktitle    = {{Research Day 2025, Abstracts}},
  keywords     = {{Pharmacokinetics,antibiotics}},
  language     = {{eng}},
  location     = {{Merelbeke, Belgium}},
  pages        = {{1}},
  publisher    = {{Ghent University}},
  title        = {{Pharmacokinetics and target attainment of fluoroquinolones in older adults : a systematic review}},
  url          = {{https://www.ugent.be/ge/en/research/research-day}},
  year         = {{2025}},
}