Academic Bibliography

 Search 200 years of publications by Ghent University researchers.
Advanced search
1 file | 526.10 KB
Add to list
  1. Search results
  2. Outcome in critically ill dogs and do...

Outcome in critically ill dogs and dogs with acute kidney injury based on neutrophil gelatinase‐associated lipocalin and tissue inhibitor of metalloproteinase‐2

Elisabeth Dorn, Ann Biscop (UGent) , Nausikaa Devriendt (UGent) , Donatienne Castelain (UGent) , Kristel Demeyere (UGent) , Emmelie Stock (UGent) , Evelyne Meyer (UGent) and Dominique Paepe (UGent)
(2025) JOURNAL OF VETERINARY INTERNAL MEDICINE. 39(2).
Author
Organization
Abstract
Background Neutrophil gelatinase-associated lipocalin (NGAL) and tissue inhibitor of metalloproteinase-2 (TIMP-2) have potential as early biomarkers for acute kidney injury (AKI) in dogs. Objectives Assess whether NGAL and TIMP-2 at admission (T0) and 24 h later (T1) identify survival in critically ill (CI) and AKI dogs, development of hospital-acquired AKI in CI dogs, and development of chronic kidney disease (CKD) in AKI dogs after 3 months. Animals Sixty-two client-owned dogs: 10 healthy, 24 with AKI, and 28 CI. Methods Prospective study with blood and urine samples collected at T0, T1, and up to 1 week in CI dogs, 1 month in healthy dogs, and 3 months in AKI dogs. Serum and urinary NGAL (sNGAL; uNGAL) and urinary TIMP-2 (uTIMP-2) were measured using validated ELISA kits. Results Dogs with AKI that did not survive had significantly higher uNGAL concentrations and u/sNGAL ratios at T0 compared with survivors (p = 0.05, n = 23; and p = 0.03, n = 21, respectively). In CI dogs, sNGAL was significantly higher in non-survivors at T0 and T1 compared with survivors (p = 0.02, n = 26; and p = 0.003, n = 26, respectively). At T0, normalized urinary tissue inhibitor of metalloproteinase-2 (u(norm)TIMP-2) was significantly higher in non-survivor CI dogs compared with survivors (p = 0.04, n = 25). No significant differences were found for the other variables. Conclusions and Clinical Relevance In AKI dogs, uNGAL and u/sNGAL at T0, and in CI dogs, sNGAL at T0 and T1 and u(norm)TIMP-2 at T0, were potential predictors of survival.
Keywords
canine, cell cycle arrest biomarker, early diagnosis, kidney disease, renal biomarker, ACUTE-RENAL-FAILURE, BIOMARKERS, SEPSIS, PATHOPHYSIOLOGY, PREDICTION, DIAGNOSIS, RECOVERY, DISEASE, MARKER, SYSTEM

Downloads

  • Download
    publisher version.pdf
    • full text (Published version)
    • |
    • open access
    • |
    • PDF
    • |
    • 526.10 KB

Citation

Please use this url to cite or link to this publication:

MLA
Dorn, Elisabeth, et al. “Outcome in Critically Ill Dogs and Dogs with Acute Kidney Injury Based on Neutrophil Gelatinase‐associated Lipocalin and Tissue Inhibitor of Metalloproteinase‐2.” JOURNAL OF VETERINARY INTERNAL MEDICINE, vol. 39, no. 2, 2025, doi:10.1111/jvim.70024.
APA
Dorn, E., Biscop, A., Devriendt, N., Castelain, D., Demeyere, K., Stock, E., … Paepe, D. (2025). Outcome in critically ill dogs and dogs with acute kidney injury based on neutrophil gelatinase‐associated lipocalin and tissue inhibitor of metalloproteinase‐2. JOURNAL OF VETERINARY INTERNAL MEDICINE, 39(2). https://doi.org/10.1111/jvim.70024
Chicago author-date
Dorn, Elisabeth, Ann Biscop, Nausikaa Devriendt, Donatienne Castelain, Kristel Demeyere, Emmelie Stock, Evelyne Meyer, and Dominique Paepe. 2025. “Outcome in Critically Ill Dogs and Dogs with Acute Kidney Injury Based on Neutrophil Gelatinase‐associated Lipocalin and Tissue Inhibitor of Metalloproteinase‐2.” JOURNAL OF VETERINARY INTERNAL MEDICINE 39 (2). https://doi.org/10.1111/jvim.70024.
Chicago author-date (all authors)
Dorn, Elisabeth, Ann Biscop, Nausikaa Devriendt, Donatienne Castelain, Kristel Demeyere, Emmelie Stock, Evelyne Meyer, and Dominique Paepe. 2025. “Outcome in Critically Ill Dogs and Dogs with Acute Kidney Injury Based on Neutrophil Gelatinase‐associated Lipocalin and Tissue Inhibitor of Metalloproteinase‐2.” JOURNAL OF VETERINARY INTERNAL MEDICINE 39 (2). doi:10.1111/jvim.70024.
Vancouver
1.
Dorn E, Biscop A, Devriendt N, Castelain D, Demeyere K, Stock E, et al. Outcome in critically ill dogs and dogs with acute kidney injury based on neutrophil gelatinase‐associated lipocalin and tissue inhibitor of metalloproteinase‐2. JOURNAL OF VETERINARY INTERNAL MEDICINE. 2025;39(2).
IEEE
[1]
E. Dorn et al., “Outcome in critically ill dogs and dogs with acute kidney injury based on neutrophil gelatinase‐associated lipocalin and tissue inhibitor of metalloproteinase‐2,” JOURNAL OF VETERINARY INTERNAL MEDICINE, vol. 39, no. 2, 2025.
@article{01JP4W7QFBRKQ22GP0QJQCVK02,
  abstract     = {{Background Neutrophil gelatinase-associated lipocalin (NGAL) and tissue inhibitor of metalloproteinase-2 (TIMP-2) have potential as early biomarkers for acute kidney injury (AKI) in dogs. Objectives Assess whether NGAL and TIMP-2 at admission (T0) and 24 h later (T1) identify survival in critically ill (CI) and AKI dogs, development of hospital-acquired AKI in CI dogs, and development of chronic kidney disease (CKD) in AKI dogs after 3 months. Animals Sixty-two client-owned dogs: 10 healthy, 24 with AKI, and 28 CI. Methods Prospective study with blood and urine samples collected at T0, T1, and up to 1 week in CI dogs, 1 month in healthy dogs, and 3 months in AKI dogs. Serum and urinary NGAL (sNGAL; uNGAL) and urinary TIMP-2 (uTIMP-2) were measured using validated ELISA kits. Results Dogs with AKI that did not survive had significantly higher uNGAL concentrations and u/sNGAL ratios at T0 compared with survivors (p = 0.05, n = 23; and p = 0.03, n = 21, respectively). In CI dogs, sNGAL was significantly higher in non-survivors at T0 and T1 compared with survivors (p = 0.02, n = 26; and p = 0.003, n = 26, respectively). At T0, normalized urinary tissue inhibitor of metalloproteinase-2 (u(norm)TIMP-2) was significantly higher in non-survivor CI dogs compared with survivors (p = 0.04, n = 25). No significant differences were found for the other variables. Conclusions and Clinical Relevance In AKI dogs, uNGAL and u/sNGAL at T0, and in CI dogs, sNGAL at T0 and T1 and u(norm)TIMP-2 at T0, were potential predictors of survival.}},
  articleno    = {{e70024}},
  author       = {{Dorn, Elisabeth and Biscop, Ann and Devriendt, Nausikaa and Castelain, Donatienne and Demeyere, Kristel and Stock, Emmelie and Meyer, Evelyne and Paepe, Dominique}},
  issn         = {{0891-6640}},
  journal      = {{JOURNAL OF VETERINARY INTERNAL MEDICINE}},
  keywords     = {{canine,cell cycle arrest biomarker,early diagnosis,kidney disease,renal biomarker,ACUTE-RENAL-FAILURE,BIOMARKERS,SEPSIS,PATHOPHYSIOLOGY,PREDICTION,DIAGNOSIS,RECOVERY,DISEASE,MARKER,SYSTEM}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{15}},
  title        = {{Outcome in critically ill dogs and dogs with acute kidney injury based on neutrophil gelatinase‐associated lipocalin and tissue inhibitor of metalloproteinase‐2}},
  url          = {{http://doi.org/10.1111/jvim.70024}},
  volume       = {{39}},
  year         = {{2025}},
}
Altmetric
View in Altmetric
Web of Science
Times cited: