Academic Bibliography

 Search 200 years of publications by Ghent University researchers.
Advanced search
2 files | 1.75 MB
Add to list
  1. Search results
  2. Preserving potential : surgeons as ke...

Preserving potential : surgeons as key partners in establishing a living sarcoma biobank for translational research purposes

Stefanie Gijsels (UGent) , Merlijn Vekeman (UGent) , Suzanne Fischer (UGent) , David Creytens (UGent) , Alexander Ackerman, Anaïs Ongenaet, Laurens Boi, Eline Segers, Jens De Temmerman (UGent) , Francesca Casteur, et al.
(2025) SURGICAL ONCOLOGY-OXFORD. 59.
Author
Organization
Project
Abstract
Background: Sarcoma is a rare type of cancer, of which over 70 distinct molecular subtypes are known. Because these tumours are so rare and complex, treatment outcomes have remained similar over the past decades and research is progressing slowly. For these rare cancers, personalised medicine and patient-derived models might pose solutions for therapeutic problems, but researchers depend on clinicians to access fresh, viable tumour tissue. Methods: Over the past five years, a bedside-to-bench flow was implemented in Ghent University Hospital for a living biobank of sarcoma tissue to support translational research. All tumour tissue was cryopreserved in cryopreservation medium (90 % foetal bovine serum and 10 % dimethyl sulfoxide) maintaining viability of the tissue. Results: As of July 2024, this biobank houses 217 sarcoma samples available for model development, biomarker discovery and precision medicine initiatives. The samples were collected from 167 patients, with 40 patients of whom we collected several samples throughout the disease course. Discussion: With this article, we aim to incentivise surgeons to engage in biobanking initiatives, as they have a unique position with direct access to fresh tumour tissue. We present our biobank and clinical flow that is implemented in daily clinical practice. The primary aim of the biobank is to advance sarcoma research by creating models and sharing data with fellow researchers.
Keywords
SOFT-TISSUE, Sarcoma, Biobanking, Translational research

Downloads

  • Download
    AAM Gijsels Surg Oncol.docx
    • full text (Accepted manuscript)
    • |
    • open access
    • |
    • Word
    • |
    • 207.11 KB
  • Download
    (...).pdf
    • full text (Published version)
    • |
    • UGent only
    • |
    • PDF
    • |
    • 1.55 MB

Citation

Please use this url to cite or link to this publication:

MLA
Gijsels, Stefanie, et al. “Preserving Potential : Surgeons as Key Partners in Establishing a Living Sarcoma Biobank for Translational Research Purposes.” SURGICAL ONCOLOGY-OXFORD, vol. 59, 2025, doi:10.1016/j.suronc.2025.102209.
APA
Gijsels, S., Vekeman, M., Fischer, S., Creytens, D., Ackerman, A., Ongenaet, A., … Sys, G. (2025). Preserving potential : surgeons as key partners in establishing a living sarcoma biobank for translational research purposes. SURGICAL ONCOLOGY-OXFORD, 59. https://doi.org/10.1016/j.suronc.2025.102209
Chicago author-date
Gijsels, Stefanie, Merlijn Vekeman, Suzanne Fischer, David Creytens, Alexander Ackerman, Anaïs Ongenaet, Laurens Boi, et al. 2025. “Preserving Potential : Surgeons as Key Partners in Establishing a Living Sarcoma Biobank for Translational Research Purposes.” SURGICAL ONCOLOGY-OXFORD 59. https://doi.org/10.1016/j.suronc.2025.102209.
Chicago author-date (all authors)
Gijsels, Stefanie, Merlijn Vekeman, Suzanne Fischer, David Creytens, Alexander Ackerman, Anaïs Ongenaet, Laurens Boi, Eline Segers, Jens De Temmerman, Francesca Casteur, Ruben Van Boxstael, Herlinde De Waele, Desirée Dorleijn, Fleur Cordier, Lore Lapeire, Gabriëlle van Ramshorst, Olivier De Wever, and Gwen Sys. 2025. “Preserving Potential : Surgeons as Key Partners in Establishing a Living Sarcoma Biobank for Translational Research Purposes.” SURGICAL ONCOLOGY-OXFORD 59. doi:10.1016/j.suronc.2025.102209.
Vancouver
1.
Gijsels S, Vekeman M, Fischer S, Creytens D, Ackerman A, Ongenaet A, et al. Preserving potential : surgeons as key partners in establishing a living sarcoma biobank for translational research purposes. SURGICAL ONCOLOGY-OXFORD. 2025;59.
IEEE
[1]
S. Gijsels et al., “Preserving potential : surgeons as key partners in establishing a living sarcoma biobank for translational research purposes,” SURGICAL ONCOLOGY-OXFORD, vol. 59, 2025.
@article{01JNKYA7YCSJD0XECFMJH29PRR,
  abstract     = {{Background: Sarcoma is a rare type of cancer, of which over 70 distinct molecular subtypes are known. Because these tumours are so rare and complex, treatment outcomes have remained similar over the past decades and research is progressing slowly. For these rare cancers, personalised medicine and patient-derived models might pose solutions for therapeutic problems, but researchers depend on clinicians to access fresh, viable tumour tissue. Methods: Over the past five years, a bedside-to-bench flow was implemented in Ghent University Hospital for a living biobank of sarcoma tissue to support translational research. All tumour tissue was cryopreserved in cryopreservation medium (90 % foetal bovine serum and 10 % dimethyl sulfoxide) maintaining viability of the tissue. Results: As of July 2024, this biobank houses 217 sarcoma samples available for model development, biomarker discovery and precision medicine initiatives. The samples were collected from 167 patients, with 40 patients of whom we collected several samples throughout the disease course. Discussion: With this article, we aim to incentivise surgeons to engage in biobanking initiatives, as they have a unique position with direct access to fresh tumour tissue. We present our biobank and clinical flow that is implemented in daily clinical practice. The primary aim of the biobank is to advance sarcoma research by creating models and sharing data with fellow researchers.}},
  articleno    = {{102209}},
  author       = {{Gijsels, Stefanie and Vekeman, Merlijn and Fischer, Suzanne and Creytens, David and Ackerman, Alexander and Ongenaet, Anaïs and Boi, Laurens and Segers, Eline and De Temmerman, Jens and Casteur, Francesca and Van Boxstael, Ruben and De Waele, Herlinde and Dorleijn, Desirée and Cordier, Fleur and Lapeire, Lore and van Ramshorst, Gabriëlle and De Wever, Olivier and Sys, Gwen}},
  issn         = {{0960-7404}},
  journal      = {{SURGICAL ONCOLOGY-OXFORD}},
  keywords     = {{SOFT-TISSUE,Sarcoma,Biobanking,Translational research}},
  language     = {{eng}},
  pages        = {{6}},
  title        = {{Preserving potential : surgeons as key partners in establishing a living sarcoma biobank for translational research purposes}},
  url          = {{http://doi.org/10.1016/j.suronc.2025.102209}},
  volume       = {{59}},
  year         = {{2025}},
}
Altmetric
View in Altmetric
Web of Science
Times cited: