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Reduced RG-II pectin dimerization disrupts differential growth by attenuating hormonal regulation

Pawan Kumar Jewaria, Bibek Aryal, Rifat Ara Begum, Yaowei Wang, Gloria Sancho-Andrés, Abu Imran Baba, Meng Yu, Xiaojuan Li, Jinxing Lin, Stephen C. Fry, et al.
(2025) SCIENCE ADVANCES. 11(7).
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Abstract
Defects in cell wall integrity (CWI) profoundly affect plant growth, although, underlying mechanisms are not well understood. We show that in Arabidopsis mur1 mutant, CWI defects from compromising dimerization of RG-II pectin, a key component of cell wall, attenuate the expression of auxin response factors ARF7-ARF19. As a result, polar auxin transport components are misexpressed, disrupting auxin response asymmetry, leading to defective apical hook development. Accordingly, mur1 hook defects are suppressed by enhancing ARF7 expression. In addition, expression of brassinosteroid biosynthesis genes is down-regulated in mur1 mutant, and supplementing brassinosteroid or enhancing brassinosteroid signaling suppresses mur1 hook defects. Intriguingly, brassinosteroid enhances RG-II dimerization, showing hormonal feedback to the cell wall. Our results thus reveal a previously unrecognized link between cell wall defects from reduced RG-II dimerization and growth regulation mediated via modulation of auxin-brassinosteroid pathways in early seedling development.
Keywords
APICAL HOOK DEVELOPMENT, ARABIDOPSIS CELL-WALLS, POLAR AUXIN TRANSPORT, RHAMNOGALACTURONAN-II, PLANT-CELL, BRASSINOSTEROID BIOSYNTHESIS, GENE-EXPRESSION, THALIANA, POLYSACCHARIDE, BORON

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MLA
Jewaria, Pawan Kumar, et al. “Reduced RG-II Pectin Dimerization Disrupts Differential Growth by Attenuating Hormonal Regulation.” SCIENCE ADVANCES, vol. 11, no. 7, 2025, doi:10.1126/sciadv.ads0760.
APA
Jewaria, P. K., Aryal, B., Begum, R. A., Wang, Y., Sancho-Andrés, G., Baba, A. I., … Bhalerao, R. P. (2025). Reduced RG-II pectin dimerization disrupts differential growth by attenuating hormonal regulation. SCIENCE ADVANCES, 11(7). https://doi.org/10.1126/sciadv.ads0760
Chicago author-date
Jewaria, Pawan Kumar, Bibek Aryal, Rifat Ara Begum, Yaowei Wang, Gloria Sancho-Andrés, Abu Imran Baba, Meng Yu, et al. 2025. “Reduced RG-II Pectin Dimerization Disrupts Differential Growth by Attenuating Hormonal Regulation.” SCIENCE ADVANCES 11 (7). https://doi.org/10.1126/sciadv.ads0760.
Chicago author-date (all authors)
Jewaria, Pawan Kumar, Bibek Aryal, Rifat Ara Begum, Yaowei Wang, Gloria Sancho-Andrés, Abu Imran Baba, Meng Yu, Xiaojuan Li, Jinxing Lin, Stephen C. Fry, Stephane Verger, Eugenia Russinova, Kristoffer Jonsson, and Rishikesh P. Bhalerao. 2025. “Reduced RG-II Pectin Dimerization Disrupts Differential Growth by Attenuating Hormonal Regulation.” SCIENCE ADVANCES 11 (7). doi:10.1126/sciadv.ads0760.
Vancouver
1.
Jewaria PK, Aryal B, Begum RA, Wang Y, Sancho-Andrés G, Baba AI, et al. Reduced RG-II pectin dimerization disrupts differential growth by attenuating hormonal regulation. SCIENCE ADVANCES. 2025;11(7).
IEEE
[1]
P. K. Jewaria et al., “Reduced RG-II pectin dimerization disrupts differential growth by attenuating hormonal regulation,” SCIENCE ADVANCES, vol. 11, no. 7, 2025.
@article{01JMHET1RDB95TB4ZZM54X4HA9,
  abstract     = {{Defects in cell wall integrity (CWI) profoundly affect plant growth, although, underlying mechanisms are not well understood. We show that in Arabidopsis mur1 mutant, CWI defects from compromising dimerization of RG-II pectin, a key component of cell wall, attenuate the expression of auxin response factors ARF7-ARF19. As a result, polar auxin transport components are misexpressed, disrupting auxin response asymmetry, leading to defective apical hook development. Accordingly, mur1 hook defects are suppressed by enhancing ARF7 expression. In addition, expression of brassinosteroid biosynthesis genes is down-regulated in mur1 mutant, and supplementing brassinosteroid or enhancing brassinosteroid signaling suppresses mur1 hook defects. Intriguingly, brassinosteroid enhances RG-II dimerization, showing hormonal feedback to the cell wall. Our results thus reveal a previously unrecognized link between cell wall defects from reduced RG-II dimerization and growth regulation mediated via modulation of auxin-brassinosteroid pathways in early seedling development.}},
  articleno    = {{eads0760}},
  author       = {{Jewaria, Pawan Kumar and Aryal, Bibek and Begum, Rifat Ara and Wang, Yaowei and Sancho-Andrés, Gloria and Baba, Abu Imran and Yu, Meng and Li, Xiaojuan and Lin, Jinxing and Fry, Stephen C. and Verger, Stephane and Russinova, Eugenia and Jonsson, Kristoffer and Bhalerao, Rishikesh P.}},
  issn         = {{2375-2548}},
  journal      = {{SCIENCE ADVANCES}},
  keywords     = {{APICAL HOOK DEVELOPMENT,ARABIDOPSIS CELL-WALLS,POLAR AUXIN TRANSPORT,RHAMNOGALACTURONAN-II,PLANT-CELL,BRASSINOSTEROID BIOSYNTHESIS,GENE-EXPRESSION,THALIANA,POLYSACCHARIDE,BORON}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{10}},
  title        = {{Reduced RG-II pectin dimerization disrupts differential growth by attenuating hormonal regulation}},
  url          = {{http://doi.org/10.1126/sciadv.ads0760}},
  volume       = {{11}},
  year         = {{2025}},
}
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