Intestinal mucus : the unsung hero in the battle against viral gastroenteritis
- Author
- Waqar Saleem (UGent) , Ateeqa Aslam (UGent) , Mehlayl Tariq and Hans Nauwynck (UGent)
- Organization
- Abstract
- Intestinal mucus plays a crucial role in defending against enteric infections by protecting the vulnerable intestinal epithelial cells both physically and through its various constituents. Despite this, numerous gastroenteritis-causing viruses, such as rotavirus, coronavirus, adenovirus, astrovirus, calicivirus, and enterovirus, continue to pose significant threats to humans and animals. While several studies have examined the interactions between these viruses and intestinal mucus, significant gaps remain in understanding the full protective potential of intestinal mucus against these pathogens. This review aims to elucidate the protective role of intestinal mucus in viral gastroenteritis. It begins with a comprehensive literature overview of (i) intestinal mucus, (ii) enteric viruses of medical and veterinary importance, and (iii) the known interactions between various enteric viruses and intestinal mucus. Following this, a case study is presented to highlight the age-dependent blocking effect of porcine intestinal mucus against transmissible gastroenteritis virus, a porcine coronavirus. Finally, the review discusses future investigation directions to further explore the potential of intestinal mucus as a defense mechanism against viral gastroenteritis to stimulate further research in this dynamic and critical area.
- Keywords
- Intestinal mucus, Viral gastroenteritis, Virus-mucus interaction, Mucosal immunology, Virus-blocking, EPIDEMIC-DIARRHEA-VIRUS, GROUP-A ROTAVIRUSES, AGE-DEPENDENT RESISTANCE, PIG GROUP-A, TRANSMISSIBLE GASTROENTERITIS, CORONAVIRUS INFECTION, EPITHELIAL-CELLS, INFLUENZA-VIRUS, GUT MICROBIOTA, GOBLET CELLS
Downloads
-
2025 WS Gut Pathog.pdf
- full text (Published version)
- |
- open access
- |
- |
- 3.81 MB
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01JMH44K2DYR85GGDY1N3EQ1GK
- MLA
- Saleem, Waqar, et al. “Intestinal Mucus : The Unsung Hero in the Battle against Viral Gastroenteritis.” GUT PATHOGENS, vol. 17, no. 1, 2025, doi:10.1186/s13099-025-00684-6.
- APA
- Saleem, W., Aslam, A., Tariq, M., & Nauwynck, H. (2025). Intestinal mucus : the unsung hero in the battle against viral gastroenteritis. GUT PATHOGENS, 17(1). https://doi.org/10.1186/s13099-025-00684-6
- Chicago author-date
- Saleem, Waqar, Ateeqa Aslam, Mehlayl Tariq, and Hans Nauwynck. 2025. “Intestinal Mucus : The Unsung Hero in the Battle against Viral Gastroenteritis.” GUT PATHOGENS 17 (1). https://doi.org/10.1186/s13099-025-00684-6.
- Chicago author-date (all authors)
- Saleem, Waqar, Ateeqa Aslam, Mehlayl Tariq, and Hans Nauwynck. 2025. “Intestinal Mucus : The Unsung Hero in the Battle against Viral Gastroenteritis.” GUT PATHOGENS 17 (1). doi:10.1186/s13099-025-00684-6.
- Vancouver
- 1.Saleem W, Aslam A, Tariq M, Nauwynck H. Intestinal mucus : the unsung hero in the battle against viral gastroenteritis. GUT PATHOGENS. 2025;17(1).
- IEEE
- [1]W. Saleem, A. Aslam, M. Tariq, and H. Nauwynck, “Intestinal mucus : the unsung hero in the battle against viral gastroenteritis,” GUT PATHOGENS, vol. 17, no. 1, 2025.
@article{01JMH44K2DYR85GGDY1N3EQ1GK,
abstract = {{Intestinal mucus plays a crucial role in defending against enteric infections by protecting the vulnerable intestinal epithelial cells both physically and through its various constituents. Despite this, numerous gastroenteritis-causing viruses, such as rotavirus, coronavirus, adenovirus, astrovirus, calicivirus, and enterovirus, continue to pose significant threats to humans and animals. While several studies have examined the interactions between these viruses and intestinal mucus, significant gaps remain in understanding the full protective potential of intestinal mucus against these pathogens. This review aims to elucidate the protective role of intestinal mucus in viral gastroenteritis. It begins with a comprehensive literature overview of (i) intestinal mucus, (ii) enteric viruses of medical and veterinary importance, and (iii) the known interactions between various enteric viruses and intestinal mucus. Following this, a case study is presented to highlight the age-dependent blocking effect of porcine intestinal mucus against transmissible gastroenteritis virus, a porcine coronavirus. Finally, the review discusses future investigation directions to further explore the potential of intestinal mucus as a defense mechanism against viral gastroenteritis to stimulate further research in this dynamic and critical area.}},
articleno = {{11}},
author = {{Saleem, Waqar and Aslam, Ateeqa and Tariq, Mehlayl and Nauwynck, Hans}},
issn = {{1757-4749}},
journal = {{GUT PATHOGENS}},
keywords = {{Intestinal mucus,Viral gastroenteritis,Virus-mucus interaction,Mucosal immunology,Virus-blocking,EPIDEMIC-DIARRHEA-VIRUS,GROUP-A ROTAVIRUSES,AGE-DEPENDENT RESISTANCE,PIG GROUP-A,TRANSMISSIBLE GASTROENTERITIS,CORONAVIRUS INFECTION,EPITHELIAL-CELLS,INFLUENZA-VIRUS,GUT MICROBIOTA,GOBLET CELLS}},
language = {{eng}},
number = {{1}},
pages = {{18}},
title = {{Intestinal mucus : the unsung hero in the battle against viral gastroenteritis}},
url = {{http://doi.org/10.1186/s13099-025-00684-6}},
volume = {{17}},
year = {{2025}},
}
- Altmetric
- View in Altmetric
- Web of Science
- Times cited: