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Early exposure to deprivation or threat moderates expected associations between neural structure and age in adolescent girls

Kathryn Garrisi, Angelina Pei-Tzu Tsai, Kinjal K. Patel, Meredith A. Gruhn, Matteo Giletta (UGent) , Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, et al.
(2025) CHILD MALTREATMENT.
Author
Organization
Abstract
Childhood adversity (CA) is associated with increased risk of negative health outcomes. Research implicates brain structure following CA as a key mechanism of this risk, and recent models suggest different forms of adversity differentially impact neural structure as a function of development (accelerated or attenuated development). Employing the Dimensional Model of Adversity and Psychopathology, we examined whether deprivation and threat differentially impact age-related change in cortical thickness, cortical surface area, and subcortical structure volume, using whole-brain and region of interest analyses (N = 135). In youth without CA, age predicted less surface area across adolescence, consistent with normative data. However, for adolescents with more deprivation exposure, as age increased there was attenuated surface area decreases in the orbitofrontal and superior-parietal cortex, regions recruited for higher-order cognition. Further, for those with more threat exposure, as age increased surface area increased in the inferior-temporal and parietal cortex, regions recruited in socio-emotional tasks. These novel findings extend work examining the impact of dimensions of adversity at a single-age and broaden current conceptualizations of how adversity might impact developmental timing.
Keywords
child adversity, adolescents, early childhood, neglect, neurocognition, CHILDHOOD ADVERSITY, BRAIN STRUCTURE, PSYCHIATRIC-DISORDERS, CORTICAL THICKNESS, CEREBRAL-CORTEX, ABUSE, MALTREATMENT, DIMENSIONS, STRESS, PSYCHOPATHOLOGY

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MLA
Garrisi, Kathryn, et al. “Early Exposure to Deprivation or Threat Moderates Expected Associations between Neural Structure and Age in Adolescent Girls.” CHILD MALTREATMENT, 2025, doi:10.1177/10775595241301746.
APA
Garrisi, K., Tsai, A. P.-T., Patel, K. K., Gruhn, M. A., Giletta, M., Hastings, P. D., … Sheridan, M. A. (2025). Early exposure to deprivation or threat moderates expected associations between neural structure and age in adolescent girls. CHILD MALTREATMENT. https://doi.org/10.1177/10775595241301746
Chicago author-date
Garrisi, Kathryn, Angelina Pei-Tzu Tsai, Kinjal K. Patel, Meredith A. Gruhn, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, et al. 2025. “Early Exposure to Deprivation or Threat Moderates Expected Associations between Neural Structure and Age in Adolescent Girls.” CHILD MALTREATMENT. https://doi.org/10.1177/10775595241301746.
Chicago author-date (all authors)
Garrisi, Kathryn, Angelina Pei-Tzu Tsai, Kinjal K. Patel, Meredith A. Gruhn, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Adam Bryant Miller, and Margaret A. Sheridan. 2025. “Early Exposure to Deprivation or Threat Moderates Expected Associations between Neural Structure and Age in Adolescent Girls.” CHILD MALTREATMENT. doi:10.1177/10775595241301746.
Vancouver
1.
Garrisi K, Tsai AP-T, Patel KK, Gruhn MA, Giletta M, Hastings PD, et al. Early exposure to deprivation or threat moderates expected associations between neural structure and age in adolescent girls. CHILD MALTREATMENT. 2025;
IEEE
[1]
K. Garrisi et al., “Early exposure to deprivation or threat moderates expected associations between neural structure and age in adolescent girls,” CHILD MALTREATMENT, 2025.
@article{01JMAXVFRH794ZM6DHG0CW9E4P,
  abstract     = {{Childhood adversity (CA) is associated with increased risk of negative health outcomes. Research implicates brain structure following CA as a key mechanism of this risk, and recent models suggest different forms of adversity differentially impact neural structure as a function of development (accelerated or attenuated development). Employing the Dimensional Model of Adversity and Psychopathology, we examined whether deprivation and threat differentially impact age-related change in cortical thickness, cortical surface area, and subcortical structure volume, using whole-brain and region of interest analyses (N = 135). In youth without CA, age predicted less surface area across adolescence, consistent with normative data. However, for adolescents with more deprivation exposure, as age increased there was attenuated surface area decreases in the orbitofrontal and superior-parietal cortex, regions recruited for higher-order cognition. Further, for those with more threat exposure, as age increased surface area increased in the inferior-temporal and parietal cortex, regions recruited in socio-emotional tasks. These novel findings extend work examining the impact of dimensions of adversity at a single-age and broaden current conceptualizations of how adversity might impact developmental timing.}},
  author       = {{Garrisi, Kathryn and Tsai, Angelina Pei-Tzu and Patel, Kinjal K. and Gruhn, Meredith A. and Giletta, Matteo and Hastings, Paul D. and Nock, Matthew K. and Rudolph, Karen D. and Slavich, George M. and Prinstein, Mitchell J. and Miller, Adam Bryant and Sheridan, Margaret A.}},
  issn         = {{1077-5595}},
  journal      = {{CHILD MALTREATMENT}},
  keywords     = {{child adversity,adolescents,early childhood,neglect,neurocognition,CHILDHOOD ADVERSITY,BRAIN STRUCTURE,PSYCHIATRIC-DISORDERS,CORTICAL THICKNESS,CEREBRAL-CORTEX,ABUSE,MALTREATMENT,DIMENSIONS,STRESS,PSYCHOPATHOLOGY}},
  language     = {{eng}},
  pages        = {{15}},
  title        = {{Early exposure to deprivation or threat moderates expected associations between neural structure and age in adolescent girls}},
  url          = {{http://doi.org/10.1177/10775595241301746}},
  year         = {{2025}},
}
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