@misc{01JJPGPYJZEA83WTAM50WPAS50,
  abstract     = {{The quest for noninvasive early markers for sensorineural hearing loss (SNHL) has yielded diverse measures of interest. However, comprehensive studies evaluating the test-retest reliability of multiple measures and stimuli within a single study are scarce, and a standardized clinical protocol for robust early markers of SNHL remains elusive. To address these gaps, this study explores the intra-subject variability of various potential EEG-biomarkers for cochlear synaptopathy (CS) and other SNHL-markers in the same individuals. Fifteen normal-hearing young adults underwent repeated measures of (extended high-frequency) pure-tone audiometry, speech-in-noise intelligibility, distortion-product otoacoustic emissions (DPOAEs), and auditory evoked potentials; comprising envelope following responses (EFR) and auditory brainstem responses (ABR). Results confirm high reliability in pure-tone audiometry, whereas the matrix sentence-test exhibited a significant learning effect. The reliability of DPOAEs varied across three evaluation methods, each employing distinct SNR-based criteria for DPOAE-datapoints. EFRs exhibited superior test-retest reliability compared to ABR-amplitudes. Our findings emphasize the need for careful interpretation of presumed noninvasive SNHL measures. While tonal-audiometry’s robustness was corroborated, we observed a confounding learning effect in longitudinal speech audiometry. The variability in DPOAEs highlights the importance of consistent ear probe replacement and meticulous measurement techniques, indicating that DPOAE test-retest reliability is significantly compromised under less-than-ideal conditions. As potential EEG-biomarkers of CS, EFRs are preferred over ABR-amplitudes based on the current study results.}},
  author       = {{De Poortere, Nele and Keshishzadeh, Sarineh and Keppler, Hannah and Dhooge, Ingeborg and Verhulst, Sarah}},
  language     = {{eng}},
  pages        = {{45}},
  series       = {{medRxiv}},
  title        = {{Intrasubject variability in potential early markers of sensorineural hearing damage}},
  url          = {{http://doi.org/10.1101/2024.01.18.24301474}},
  year         = {{2024}},
}

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