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The effect of axenic dietary restriction on the age-related changes in Caenorhabditis elegans

Ping Wu (UGent) , Lieselot Vandemeulebroucke, Myriam Claeys (UGent) , Wim Bert (UGent) and Bart Braeckman (UGent)
(2024) JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 79(11).
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Abstract
Axenic dietary restriction (ADR) is highly effective in extending lifespan of Caenorhabditis elegans, but its effects on healthspan improvement are less well characterized. Using transmission electron microscopy, morphometric analyses, and functional assays, we found ADR can preserve tissue ultrastructure, including the cuticle, epidermis, and intestinal lumen, and reduce age-associated pathologies like gonad degeneration, uterine tumor clusters, pharyngeal deterioration, and intestinal atrophy. However, there was no notable improvement in behavioral and functional metrics. Our results underscore that lifespan extension through ADR does not inherently translate to broad healthspan improvements.
Keywords
Axenic dietary restriction, C elegans, Healthspan, Lifespan, EXTENDS LIFE-SPAN, RESISTANCE, MUTATION, DECLINE

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Citation

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MLA
Wu, Ping, et al. “The Effect of Axenic Dietary Restriction on the Age-Related Changes in Caenorhabditis Elegans.” JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, edited by Gustavo Duque, vol. 79, no. 11, 2024, doi:10.1093/gerona/glae205.
APA
Wu, P., Vandemeulebroucke, L., Claeys, M., Bert, W., & Braeckman, B. (2024). The effect of axenic dietary restriction on the age-related changes in Caenorhabditis elegans. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, 79(11). https://doi.org/10.1093/gerona/glae205
Chicago author-date
Wu, Ping, Lieselot Vandemeulebroucke, Myriam Claeys, Wim Bert, and Bart Braeckman. 2024. “The Effect of Axenic Dietary Restriction on the Age-Related Changes in Caenorhabditis Elegans.” Edited by Gustavo Duque. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 79 (11). https://doi.org/10.1093/gerona/glae205.
Chicago author-date (all authors)
Wu, Ping, Lieselot Vandemeulebroucke, Myriam Claeys, Wim Bert, and Bart Braeckman. 2024. “The Effect of Axenic Dietary Restriction on the Age-Related Changes in Caenorhabditis Elegans.” Ed by. Gustavo Duque. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 79 (11). doi:10.1093/gerona/glae205.
Vancouver
1.
Wu P, Vandemeulebroucke L, Claeys M, Bert W, Braeckman B. The effect of axenic dietary restriction on the age-related changes in Caenorhabditis elegans. Duque G, editor. JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES. 2024;79(11).
IEEE
[1]
P. Wu, L. Vandemeulebroucke, M. Claeys, W. Bert, and B. Braeckman, “The effect of axenic dietary restriction on the age-related changes in Caenorhabditis elegans,” JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES, vol. 79, no. 11, 2024.
@article{01JJF4TMXGQYAEX94F1V6F9ZM7,
  abstract     = {{Axenic dietary restriction (ADR) is highly effective in extending lifespan of Caenorhabditis elegans, but its effects on healthspan improvement are less well characterized. Using transmission electron microscopy, morphometric analyses, and functional assays, we found ADR can preserve tissue ultrastructure, including the cuticle, epidermis, and intestinal lumen, and reduce age-associated pathologies like gonad degeneration, uterine tumor clusters, pharyngeal deterioration, and intestinal atrophy. However, there was no notable improvement in behavioral and functional metrics. Our results underscore that lifespan extension through ADR does not inherently translate to broad healthspan improvements.}},
  articleno    = {{glae205}},
  author       = {{Wu, Ping and Vandemeulebroucke, Lieselot and Claeys, Myriam and Bert, Wim and Braeckman, Bart}},
  editor       = {{Duque, Gustavo}},
  issn         = {{1079-5006}},
  journal      = {{JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES}},
  keywords     = {{Axenic dietary restriction,C elegans,Healthspan,Lifespan,EXTENDS LIFE-SPAN,RESISTANCE,MUTATION,DECLINE}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{12}},
  title        = {{The effect of axenic dietary restriction on the age-related changes in Caenorhabditis elegans}},
  url          = {{http://doi.org/10.1093/gerona/glae205}},
  volume       = {{79}},
  year         = {{2024}},
}
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