@article{01JJ1RHBHZ2NFXF15D6N1H43H5,
  abstract     = {{Background Gardnerella is a key pathogen in bacterial vaginosis (BV), but the role of the different Gardnerella species remains unclear. We investigated the role of four Gardnerella species, as well as Fannyhessea vaginae, Lactobacillus crispatus and L. iners in BV.Methods From 331 pregnant women from the Democratic Republic of the Congo, BV was diagnosed using Nugent scoring and a cervicovaginal lavage was used to quantify G. leopoldii, G. piotii, G. swidsinskii, G. vaginalis, F. vaginae, L. crispatus and L. iners by qPCR. Univariate associations between these species and clinical outcomes were assessed. A logistic regression model and ROC curves were calculated to determine the best diagnostic marker for BV.Results Here, L. iners (75.8%) was the most prevalent species and G. vaginalis (36.0%) the most common Gardnerella species. All investigated Gardnerella spp. were prevalent (50.9-57.9%) in women with (asymptomatic) BV. Univariate analysis revealed no significant associations with clinical symptoms of BV, while F. vaginae (positive Whiff test, high pH), G. vaginalis (high pH) and L. crispatus (low pH) were associated with signs of BV. G. piotii was associated with markers of urinary tract infection. Women with L. iners had higher odds of delivering preterm. ROC analyses showed that F. vaginae was the best marker for BV (AUC 0.81), and the combined model further increased the diagnostic performance (AUC 0.90).Conclusion All Gardnerella species were involved in BV, although none were associated with the most important clinical symptoms of BV and none emerged as a superior molecular marker for BV.}},
  articleno    = {{1514884}},
  author       = {{Himschoot, Lisa and Mulinganya, Guy and Rogier, Tess and Bisimwa, Ghislain and Kampara, Freddy and Kujirakwinja, Yvette and Mongane, Jules and Mubalama, Innocent and Callens, Steven and Vaneechoutte, Mario and Cools, Piet}},
  issn         = {{2235-2988}},
  journal      = {{FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY}},
  keywords     = {{bacterial vaginosis,<italic>Gardnerella</italic>,molecular diagnosis,preterm birth,low birthweight,Democratic Republic of the Congo,BACTERIAL VAGINOSIS,ATOPOBIUM-VAGINAE,ASSOCIATION,ACQUISITION,PCR}},
  language     = {{eng}},
  pages        = {{16}},
  title        = {{Prevalence and clinical correlates of Gardnerella spp., Fannyhessea vaginae, Lactobacillus crispatus and L. iners in pregnant women in Bukavu, Democratic Republic of the Congo}},
  url          = {{http://doi.org/10.3389/fcimb.2024.1514884}},
  volume       = {{14}},
  year         = {{2025}},
}

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