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The motility of campylobacter jejuni is a highly variable and complex phenotype

(2025) SSRN.
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Abstract
Campylobacter jejuni motility is essential for colonization of the host gastrointestinal tract for which the flagellum allows the bacteria to swim in viscous environment. To understand the mechanisms that control this phenotype, the genomic characteristics that support motility were compared among 136 C. jejuni strains isolated at different stages along the poultry food chain, and from human hosts. For each isolate, the swarming distance in viscous medium was measured, and the occurrence of C. jejuni-motility associated genes and nucleotide variants, including the phase state of those phase-variable (PV) genes, was evaluated. A high variability of the motility phenotype and a wide diversity of gene patterns and phasotypes in C. jejuni were observed, that indicated that motility is a complex phenotype for which the bacteria are able to efficiently combine the flagellar genes in different ways to promote distinct motility performances. Within these systems, the full length of flagellar genes, including the flagellar motor proteins MotA and MotB, FlhF, FlgP and CheY might be crucial for C. jejuni motility. Furthermore, the high proportion of PV genes located in the O-linked glycosylation locus might lead to different flagella composition, which ultimately would explain the variability of the motility phenotype in the bacteria.

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MLA
Ortega Sanz, Irene, et al. “The Motility of Campylobacter Jejuni Is a Highly Variable and Complex Phenotype.” SSRN, 2025, doi:10.2139/ssrn.5079358.
APA
Ortega Sanz, I., Rovira, J., Megías, G., Rivero-Pérez, M. D., & Melero, B. (2025). The motility of campylobacter jejuni is a highly variable and complex phenotype. https://doi.org/10.2139/ssrn.5079358
Chicago author-date
Ortega Sanz, Irene, Jordi Rovira, Gregoria Megías, María Dolores Rivero-Pérez, and Beatriz Melero. 2025. “The Motility of Campylobacter Jejuni Is a Highly Variable and Complex Phenotype.” SSRN. https://doi.org/10.2139/ssrn.5079358.
Chicago author-date (all authors)
Ortega Sanz, Irene, Jordi Rovira, Gregoria Megías, María Dolores Rivero-Pérez, and Beatriz Melero. 2025. “The Motility of Campylobacter Jejuni Is a Highly Variable and Complex Phenotype.” SSRN. doi:10.2139/ssrn.5079358.
Vancouver
1.
Ortega Sanz I, Rovira J, Megías G, Rivero-Pérez MD, Melero B. The motility of campylobacter jejuni is a highly variable and complex phenotype. SSRN. 2025.
IEEE
[1]
I. Ortega Sanz, J. Rovira, G. Megías, M. D. Rivero-Pérez, and B. Melero, “The motility of campylobacter jejuni is a highly variable and complex phenotype,” SSRN. 2025.
@misc{01JHJF25KG2Z71MQZEC4THEJCW,
  abstract     = {{Campylobacter jejuni motility is essential for colonization of the host gastrointestinal tract for which the flagellum allows the bacteria to swim in viscous environment. To understand the mechanisms that control this phenotype, the genomic characteristics that support motility were compared among 136 C. jejuni strains isolated at different stages along the poultry food chain, and from human hosts. For each isolate, the swarming distance in viscous medium was measured, and the occurrence of C. jejuni-motility associated genes and nucleotide variants, including the phase state of those phase-variable (PV) genes, was evaluated. A high variability of the motility phenotype and a wide diversity of gene patterns and phasotypes in C. jejuni were observed, that indicated that motility is a complex phenotype for which the bacteria are able to efficiently combine the flagellar genes in different ways to promote distinct motility performances. Within these systems, the full length of flagellar genes, including the flagellar motor proteins MotA and MotB, FlhF, FlgP and CheY might be crucial for C. jejuni motility. Furthermore, the high proportion of PV genes located in the O-linked glycosylation locus might lead to different flagella composition, which ultimately would explain the variability of the motility phenotype in the bacteria.}},
  author       = {{Ortega Sanz, Irene and Rovira, Jordi and Megías, Gregoria and Rivero-Pérez, María Dolores and Melero, Beatriz}},
  language     = {{eng}},
  pages        = {{1242}},
  series       = {{SSRN}},
  title        = {{The motility of campylobacter jejuni is a highly variable and complex phenotype}},
  url          = {{http://doi.org/10.2139/ssrn.5079358}},
  year         = {{2025}},
}

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