@misc{01JHJETCCKHWDZWZVSPHP23RQZ,
  abstract     = {{The ability of Campylobacter jejuni to survive and persist under harsh conditions is linked to the presence of flagella that promotes motility of the bacteria towards their optimum environment. The aim of this study was to examine the genetic basis for motility within 136 C. jejuni isolates through two different Genome-Wide Association Studies, gene presence/absence and Single Nucleotide Polymorphisms (SNPs). The motility phenotype was widely distributed across the phylogeny with large intra-lineage swarming performance variabilities. A number of accessory genes significantly associated with motility were found delimiting four genomic regions, one of which affected the Cj0727-Cj0733 operon, that encodes a putative ABC transporter system for phosphate uptake for ATP production, and other the capsule biosynthesis locus. Multiple SNPs mostly linked to increased motility were also discovered in clusters of genes, with special relevance to transporter and membrane proteins. Therefore, the structure and composition of the capsule and membrane mediating nutrient transference might be important for energy availability to promote flagella rotation in C. jejuni. Unrevealing the genetic virulence mechanism of this pathogen is key to identify genetic markers for molecular-based risk assessment assay for human pathogenic C. jejuni or design of novel therapeutic targets.}},
  author       = {{Ortega Sanz, Irene and Rovira, Jordi and Megías, Gregoria and Rivero-Pérez, María Dolores and Melero, Beatriz}},
  keywords     = {{genomics,bacterial GWAS,phenotype,pangenome,SNP,genetic marker}},
  language     = {{eng}},
  pages        = {{2850}},
  series       = {{SSRN}},
  title        = {{Genome-wide association study to identify genetic markers associated with Campylobacter jejuni motility}},
  url          = {{http://doi.org/10.2139/ssrn.5079357}},
  year         = {{2025}},
}

Altmetric

View in Altmetric