
Lifestyle factors and breast cancer in females with PTEN Hamartoma Tumor Syndrome (PHTS)
- Author
- Linda A. J. Hendricks, Katja C. J. Verbeek, Janneke H. M. Schuurs-Hoeijmakers, Arjen R. Mensenkamp, Hilde Brems, Robin de Putter (UGent) , Violetta C. Anastasiadou, Marie-Charlotte Villy, Arne Jahn, Verena Steinke-Lange, Margherita Baldassarri, Arvids Irmejs, Mirjam M. de Jong, Thera P. Links, Edward M. Leter, Danielle G. M. Bosch, Hildegunn Hoberg-Vetti, Marianne Tveit Haavind, Kjersti Jorgensen, Lovise Maehle, Ana Blatnik, Joan Brunet, Esther Darder, Emma Tham, Nicoline Hoogerbrugge and Janet R. Vos
- Organization
- Abstract
- Simple Summary: Females with PTEN Hamartoma Tumor Syndrome (PHTS) have very high hereditary breast cancer risks up to 76%. The aim of this European cohort study was to the describe the lifestyle in PHTS patients and to assess associations between physical activity, alcohol consumption, tobacco smoking, BMI and breast cancer in female adult PHTS patients. It was observed that of 125 patients who completed the questionnaire, 81% were >= 2 times/week physically active, 86% consumed on average <1 glass of alcohol/day, 78% never smoked and most patients were overweight or obese (72%). In total, 39 developed breast cancer (31%). No indications were found that associations between lifestyle and breast cancer in PHTS patients are different from the general population. These findings suggest that awareness about lifestyle among PHTS patients is important, as a healthier lifestyle could potentially decrease their breast cancer risk in a similar way as for the general population. Females with PTEN Hamartoma Tumor Syndrome (PHTS) have breast cancer risks up to 76%. This study assessed associations between breast cancer and lifestyle in European female adult PHTS patients. Data were collected via patient questionnaires (July 2020-March 2023) and genetic diagnoses from medical files. Associations between lifestyle and breast cancer were calculated using logistic regression corrected for age. Index patients with breast cancer before PHTS diagnosis (breast cancer index) were excluded for ascertainment bias correction. In total, 125 patients were included who completed the questionnaire at a mean age of 44 years (SD = 13). This included 21 breast cancer indexes (17%) and 39 females who developed breast cancer at 43 years (SD = 9). Breast cancer patients performed about 1.1 times less often 0-1 times/week physical activity than >= 2 times (ORtotal-adj = 0.9 (95%CI 0.3-2.6); consumed daily about 1.2-1.8 times more often >= 1 than 0-1 glasses of alcohol (ORtotal-adj = 1.2 (95%CI 0.4-4.0); ORnon-breastcancer-index-adj = 1.8 (95%CI 0.4-6.9); were about 1.04-1.3 times more often smokers than non-smokers (ORtotal-adj = 1.04 (95%CI 0.4-2.8); ORnon-breastcancer-index-adj = 1.3 (95%CI 0.4-4.2)); and overweight or obesity (72%) was about 1.02-1.3 times less common (ORtotal-adj = 0.98 (95%CI 0.4-2.6); ORnon-breastcancer-index-adj = 0.8 (95%CI 0.3-2.7)). Similar associations between lifestyle and breast cancer are suggested for PHTS and the general population. Despite not being statistically significant, results are clinically relevant and suggest that awareness of the effects of lifestyle on patients' breast cancer risk is important.
- Keywords
- alcohol drinking, body mass index, breast neoplasm, exercise, hamartoma syndrome, multiple, PHYSICAL-ACTIVITY, ALCOHOL-CONSUMPTION, RISK, SMOKING, HEALTH, BRCA1, OVERWEIGHT, CARRIERS, OBESITY, PREVENTION
Downloads
-
publisher version.pdf
- full text (Published version)
- |
- open access
- |
- |
- 552.71 KB
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01JHFB3KJ9S0Y8FNY7Q2VT2AS5
- MLA
- Hendricks, Linda A. J., et al. “Lifestyle Factors and Breast Cancer in Females with PTEN Hamartoma Tumor Syndrome (PHTS).” CANCERS, vol. 16, no. 5, 2024, doi:10.3390/cancers16050953.
- APA
- Hendricks, L. A. J., Verbeek, K. C. J., Schuurs-Hoeijmakers, J. H. M., Mensenkamp, A. R., Brems, H., de Putter, R., … Vos, J. R. (2024). Lifestyle factors and breast cancer in females with PTEN Hamartoma Tumor Syndrome (PHTS). CANCERS, 16(5). https://doi.org/10.3390/cancers16050953
- Chicago author-date
- Hendricks, Linda A. J., Katja C. J. Verbeek, Janneke H. M. Schuurs-Hoeijmakers, Arjen R. Mensenkamp, Hilde Brems, Robin de Putter, Violetta C. Anastasiadou, et al. 2024. “Lifestyle Factors and Breast Cancer in Females with PTEN Hamartoma Tumor Syndrome (PHTS).” CANCERS 16 (5). https://doi.org/10.3390/cancers16050953.
- Chicago author-date (all authors)
- Hendricks, Linda A. J., Katja C. J. Verbeek, Janneke H. M. Schuurs-Hoeijmakers, Arjen R. Mensenkamp, Hilde Brems, Robin de Putter, Violetta C. Anastasiadou, Marie-Charlotte Villy, Arne Jahn, Verena Steinke-Lange, Margherita Baldassarri, Arvids Irmejs, Mirjam M. de Jong, Thera P. Links, Edward M. Leter, Danielle G. M. Bosch, Hildegunn Hoberg-Vetti, Marianne Tveit Haavind, Kjersti Jorgensen, Lovise Maehle, Ana Blatnik, Joan Brunet, Esther Darder, Emma Tham, Nicoline Hoogerbrugge, and Janet R. Vos. 2024. “Lifestyle Factors and Breast Cancer in Females with PTEN Hamartoma Tumor Syndrome (PHTS).” CANCERS 16 (5). doi:10.3390/cancers16050953.
- Vancouver
- 1.Hendricks LAJ, Verbeek KCJ, Schuurs-Hoeijmakers JHM, Mensenkamp AR, Brems H, de Putter R, et al. Lifestyle factors and breast cancer in females with PTEN Hamartoma Tumor Syndrome (PHTS). CANCERS. 2024;16(5).
- IEEE
- [1]L. A. J. Hendricks et al., “Lifestyle factors and breast cancer in females with PTEN Hamartoma Tumor Syndrome (PHTS),” CANCERS, vol. 16, no. 5, 2024.
@article{01JHFB3KJ9S0Y8FNY7Q2VT2AS5, abstract = {{Simple Summary: Females with PTEN Hamartoma Tumor Syndrome (PHTS) have very high hereditary breast cancer risks up to 76%. The aim of this European cohort study was to the describe the lifestyle in PHTS patients and to assess associations between physical activity, alcohol consumption, tobacco smoking, BMI and breast cancer in female adult PHTS patients. It was observed that of 125 patients who completed the questionnaire, 81% were >= 2 times/week physically active, 86% consumed on average <1 glass of alcohol/day, 78% never smoked and most patients were overweight or obese (72%). In total, 39 developed breast cancer (31%). No indications were found that associations between lifestyle and breast cancer in PHTS patients are different from the general population. These findings suggest that awareness about lifestyle among PHTS patients is important, as a healthier lifestyle could potentially decrease their breast cancer risk in a similar way as for the general population. Females with PTEN Hamartoma Tumor Syndrome (PHTS) have breast cancer risks up to 76%. This study assessed associations between breast cancer and lifestyle in European female adult PHTS patients. Data were collected via patient questionnaires (July 2020-March 2023) and genetic diagnoses from medical files. Associations between lifestyle and breast cancer were calculated using logistic regression corrected for age. Index patients with breast cancer before PHTS diagnosis (breast cancer index) were excluded for ascertainment bias correction. In total, 125 patients were included who completed the questionnaire at a mean age of 44 years (SD = 13). This included 21 breast cancer indexes (17%) and 39 females who developed breast cancer at 43 years (SD = 9). Breast cancer patients performed about 1.1 times less often 0-1 times/week physical activity than >= 2 times (ORtotal-adj = 0.9 (95%CI 0.3-2.6); consumed daily about 1.2-1.8 times more often >= 1 than 0-1 glasses of alcohol (ORtotal-adj = 1.2 (95%CI 0.4-4.0); ORnon-breastcancer-index-adj = 1.8 (95%CI 0.4-6.9); were about 1.04-1.3 times more often smokers than non-smokers (ORtotal-adj = 1.04 (95%CI 0.4-2.8); ORnon-breastcancer-index-adj = 1.3 (95%CI 0.4-4.2)); and overweight or obesity (72%) was about 1.02-1.3 times less common (ORtotal-adj = 0.98 (95%CI 0.4-2.6); ORnon-breastcancer-index-adj = 0.8 (95%CI 0.3-2.7)). Similar associations between lifestyle and breast cancer are suggested for PHTS and the general population. Despite not being statistically significant, results are clinically relevant and suggest that awareness of the effects of lifestyle on patients' breast cancer risk is important.}}, articleno = {{953}}, author = {{Hendricks, Linda A. J. and Verbeek, Katja C. J. and Schuurs-Hoeijmakers, Janneke H. M. and Mensenkamp, Arjen R. and Brems, Hilde and de Putter, Robin and Anastasiadou, Violetta C. and Villy, Marie-Charlotte and Jahn, Arne and Steinke-Lange, Verena and Baldassarri, Margherita and Irmejs, Arvids and de Jong, Mirjam M. and Links, Thera P. and Leter, Edward M. and Bosch, Danielle G. M. and Hoberg-Vetti, Hildegunn and Tveit Haavind, Marianne and Jorgensen, Kjersti and Maehle, Lovise and Blatnik, Ana and Brunet, Joan and Darder, Esther and Tham, Emma and Hoogerbrugge, Nicoline and Vos, Janet R.}}, issn = {{2072-6694}}, journal = {{CANCERS}}, keywords = {{alcohol drinking,body mass index,breast neoplasm,exercise,hamartoma syndrome,multiple,PHYSICAL-ACTIVITY,ALCOHOL-CONSUMPTION,RISK,SMOKING,HEALTH,BRCA1,OVERWEIGHT,CARRIERS,OBESITY,PREVENTION}}, language = {{eng}}, number = {{5}}, pages = {{10}}, title = {{Lifestyle factors and breast cancer in females with PTEN Hamartoma Tumor Syndrome (PHTS)}}, url = {{http://doi.org/10.3390/cancers16050953}}, volume = {{16}}, year = {{2024}}, }
- Altmetric
- View in Altmetric
- Web of Science
- Times cited: