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Shortening of the telomere length during the transition period of dairy cows in relation to biological stress

Manon Dewulf (UGent) , Osvaldo Américo Bogado Pascottini (UGent) , Stijn Heirbaut (UGent) , Maya Meesters (UGent) , Dries S. Martens, Tim S. Nawrot, Mingqi Zhang, X. P. Jing, Leen Vandaele, Veerle Fievez (UGent) , et al.
(2024) SCIENTIFIC REPORTS. 14(1).
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Abstract
Telomere length (TL) is a recognized biomarker for ageing in multiple species. In dairy cattle, the transition period is considered a very stressful period. We hypothesized that TL shortens during this period. Holstein cows (n = 61) were followed during the transition period. Blood and milk samples were collected at - 7, 3, 6, 9, 21d relative to calving to determine concentrations of oxidative, energetic metabolic, and inflammatory markers. Average relative leukocyte TL was measured by a modified qPCR protocol 7d before and 21d after parturition. We confirmed TL attrition during the transition period (P = 0.02), as TL was 1.05 +/- 0.229 (mean +/- SD) before, and 0.97 +/- 0.191 (mean +/- SD) after parturition. Univariable analyses assessed associations between blood markers and TL shortening. Greater plasma oxidative parameters, including oxidized glutathione and glutathione peroxidase, were positively and negatively (respectively) associated with TL attrition. Higher blood alpha- and beta-globulin were all positively associated, while IGF-1, albumin-globulin ratio and albumin were negatively associated with TL attrition. Greater serum amyloid A and haptoglobin were linked with greater TL shortening. This study reveals significant TL shortening during the transition period in dairy cows and identifies significant associations with oxidative stress, metabolic stress, and inflammation. While these associations are observed, no causality can be established. Our findings suggest the need for further research to explore the effects of transition-related stress on TL dynamics.
Keywords
OXIDATIVE STRESS, METABOLIC STATUS, PERFORMANCE, BLOOD, AGE, ASSOCIATION, BIOMARKER, SEQUENCE, DISEASE, Oxidative and energetic metabolic stress, Systemic inflammation, Longevity, Telomere-attrition

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MLA
Dewulf, Manon, et al. “Shortening of the Telomere Length during the Transition Period of Dairy Cows in Relation to Biological Stress.” SCIENTIFIC REPORTS, vol. 14, no. 1, 2024, doi:10.1038/s41598-024-82664-5.
APA
Dewulf, M., Bogado Pascottini, O. A., Heirbaut, S., Meesters, M., Martens, D. S., Nawrot, T. S., … Opsomer, G. (2024). Shortening of the telomere length during the transition period of dairy cows in relation to biological stress. SCIENTIFIC REPORTS, 14(1). https://doi.org/10.1038/s41598-024-82664-5
Chicago author-date
Dewulf, Manon, Osvaldo Américo Bogado Pascottini, Stijn Heirbaut, Maya Meesters, Dries S. Martens, Tim S. Nawrot, Mingqi Zhang, et al. 2024. “Shortening of the Telomere Length during the Transition Period of Dairy Cows in Relation to Biological Stress.” SCIENTIFIC REPORTS 14 (1). https://doi.org/10.1038/s41598-024-82664-5.
Chicago author-date (all authors)
Dewulf, Manon, Osvaldo Américo Bogado Pascottini, Stijn Heirbaut, Maya Meesters, Dries S. Martens, Tim S. Nawrot, Mingqi Zhang, X. P. Jing, Leen Vandaele, Veerle Fievez, Mieke Van Eetvelde, and Geert Opsomer. 2024. “Shortening of the Telomere Length during the Transition Period of Dairy Cows in Relation to Biological Stress.” SCIENTIFIC REPORTS 14 (1). doi:10.1038/s41598-024-82664-5.
Vancouver
1.
Dewulf M, Bogado Pascottini OA, Heirbaut S, Meesters M, Martens DS, Nawrot TS, et al. Shortening of the telomere length during the transition period of dairy cows in relation to biological stress. SCIENTIFIC REPORTS. 2024;14(1).
IEEE
[1]
M. Dewulf et al., “Shortening of the telomere length during the transition period of dairy cows in relation to biological stress,” SCIENTIFIC REPORTS, vol. 14, no. 1, 2024.
@article{01JHFAK6VWZD168A5Y3NMMKPZK,
  abstract     = {{Telomere length (TL) is a recognized biomarker for ageing in multiple species. In dairy cattle, the transition period is considered a very stressful period. We hypothesized that TL shortens during this period. Holstein cows (n = 61) were followed during the transition period. Blood and milk samples were collected at - 7, 3, 6, 9, 21d relative to calving to determine concentrations of oxidative, energetic metabolic, and inflammatory markers. Average relative leukocyte TL was measured by a modified qPCR protocol 7d before and 21d after parturition. We confirmed TL attrition during the transition period (P = 0.02), as TL was 1.05 +/- 0.229 (mean +/- SD) before, and 0.97 +/- 0.191 (mean +/- SD) after parturition. Univariable analyses assessed associations between blood markers and TL shortening. Greater plasma oxidative parameters, including oxidized glutathione and glutathione peroxidase, were positively and negatively (respectively) associated with TL attrition. Higher blood alpha- and beta-globulin were all positively associated, while IGF-1, albumin-globulin ratio and albumin were negatively associated with TL attrition. Greater serum amyloid A and haptoglobin were linked with greater TL shortening. This study reveals significant TL shortening during the transition period in dairy cows and identifies significant associations with oxidative stress, metabolic stress, and inflammation. While these associations are observed, no causality can be established. Our findings suggest the need for further research to explore the effects of transition-related stress on TL dynamics.}},
  articleno    = {{31756}},
  author       = {{Dewulf, Manon and Bogado Pascottini, Osvaldo Américo and Heirbaut, Stijn and Meesters, Maya and Martens, Dries S. and Nawrot, Tim S. and Zhang, Mingqi and Jing, X. P. and Vandaele, Leen and Fievez, Veerle and Van Eetvelde, Mieke and Opsomer, Geert}},
  issn         = {{2045-2322}},
  journal      = {{SCIENTIFIC REPORTS}},
  keywords     = {{OXIDATIVE STRESS,METABOLIC STATUS,PERFORMANCE,BLOOD,AGE,ASSOCIATION,BIOMARKER,SEQUENCE,DISEASE,Oxidative and energetic metabolic stress,Systemic inflammation,Longevity,Telomere-attrition}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{11}},
  title        = {{Shortening of the telomere length during the transition period of dairy cows in relation to biological stress}},
  url          = {{http://doi.org/10.1038/s41598-024-82664-5}},
  volume       = {{14}},
  year         = {{2024}},
}
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