@article{01JHFAJF3J1EWNJYTKXJEF5J17,
  abstract     = {{Purpose: To validate the performance of computer-aided detection (CAD) and volumetry software using an anthropomorphic phantom with a ground truth (GT) set of 3D-printed nodules. Methods: The Kyoto Kaguku Lungman phantom, containing 3D-printed solid nodules including six diameters (4 to 9 mm) and three morphologies (smooth, lobulated, spiculated), was scanned at varying CTDIvol levels (6.04, 1.54 and 0.20 mGy). Combinations of reconstruction algorithms (iterative and deep learning image reconstruction) and kernels (soft and hard) were applied. Detection, volumetry and density results recorded by a commercially available AI-based algorithm (AVIEW LCS + ) were compared to the absolute GT, which was determined through mu CT scanning at 50 mu m resolution. The associations between image acquisition parameters or nodule characteristics and accuracy of nodule detection and characterization were analyzed with chi square tests and multiple linear regression. Results: High levels of detection sensitivity and precision (minimal 83 % and 91 % respectively) were observed across all acquisitions. Neither reconstruction algorithm nor radiation dose showed significant associations with detection. Nodule diameter however showed a highly significant association with detection (p < 0.0001). Volumetric measurements for nodules > 6 mm were accurate within 10 % absolute range from volume(GT), regardless of dose and reconstruction. Nodule diameter and morphology are major determinants of volumetric accuracy (p < 0.001). Density assignment was not significantly influenced by any parameters. Conclusions: Our study confirms the software's accurate performance in nodule volumetry, detection and density characterization with robustness for variations in CT imaging protocols. This study suggests the incorporation of similar phantom setups in quality assurance of CAD tools.}},
  articleno    = {{103344}},
  author       = {{D'hondt, Louise and Kellens, Pieter-Jan and Torfs, Kwinten and Bosmans, Hilde and Bacher, Klaus and Snoeckx, Annemiek}},
  issn         = {{1120-1797}},
  journal      = {{PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS}},
  keywords     = {{Computer-aided detection,Automatic nodule volumetry,Artificial intelligence,Anthropomorphic chest phantom,Pulmonary nodules,Nodule morphology,Low-dose computed tomography,Lung cancer screening,LUNG-CANCER,PULMONARY NODULES,PERFORMANCE,AI}},
  language     = {{eng}},
  pages        = {{10}},
  title        = {{Absolute ground truth-based validation of computer-aided nodule detection and volumetry in low-dose CT imaging}},
  url          = {{http://doi.org/10.1016/j.ejmp.2024.103344}},
  volume       = {{121}},
  year         = {{2024}},
}

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