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The many functions of carbohydrate-active enzymes in family GH65 : diversity and application

Emma De Beul (UGent) , Jorick Franceus (UGent) and Tom Desmet (UGent)
(2024) APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 108(1).
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Abstract
Glycoside Hydrolase family 65 (GH65) is a unique family of carbohydrate-active enzymes. It is the first protein family to bring together glycoside hydrolases, glycoside phosphorylases and glycosyltransferases, thereby spanning a broad range of reaction types. These enzymes catalyze the hydrolysis, reversible phosphorolysis or synthesis of various alpha-glucosides, typically alpha-glucobioses or their derivatives. In this review, we present a comprehensive overview of the diverse reaction types and substrate specificities found in family GH65. We describe the determinants that control this remarkable diversity, as well as the applications of GH65 enzymes for carbohydrate synthesis. center dot GH65 is the first CAZy family to contain hydrolases, phosphorylases and transferases center dot Distinct residues and loops are determinants of substrate specificity in family GH65 center dot GH65 enzymes hold strong potential for carbohydrate synthesis via coupled reactions
Keywords
Glycoside Hydrolase family 65, Carbohydrate-active enzymes, Glycoside hydrolases, Glycoside phosphorylases, Glycosyltransferases, Specificity determinants, One-pot cascade reactions, LACTOBACILLUS-ACIDOPHILUS NCFM, BACILLUS-STEAROTHERMOPHILUS SK-1, TREHALOSE PHOSPHORYLASE, MALTOSE PHOSPHORYLASE, ACID TREHALASE, THERMOANAEROBACTER-BROCKII, ENZYMATIC-SYNTHESIS, KOJIBIOSE PHOSPHORYLASE, REVERSE PHOSPHOROLYSIS, SUBSTRATE-SPECIFICITY

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MLA
De Beul, Emma, et al. “The Many Functions of Carbohydrate-Active Enzymes in Family GH65 : Diversity and Application.” APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 108, no. 1, 2024, doi:10.1007/s00253-024-13301-4.
APA
De Beul, E., Franceus, J., & Desmet, T. (2024). The many functions of carbohydrate-active enzymes in family GH65 : diversity and application. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 108(1). https://doi.org/10.1007/s00253-024-13301-4
Chicago author-date
De Beul, Emma, Jorick Franceus, and Tom Desmet. 2024. “The Many Functions of Carbohydrate-Active Enzymes in Family GH65 : Diversity and Application.” APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 108 (1). https://doi.org/10.1007/s00253-024-13301-4.
Chicago author-date (all authors)
De Beul, Emma, Jorick Franceus, and Tom Desmet. 2024. “The Many Functions of Carbohydrate-Active Enzymes in Family GH65 : Diversity and Application.” APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 108 (1). doi:10.1007/s00253-024-13301-4.
Vancouver
1.
De Beul E, Franceus J, Desmet T. The many functions of carbohydrate-active enzymes in family GH65 : diversity and application. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 2024;108(1).
IEEE
[1]
E. De Beul, J. Franceus, and T. Desmet, “The many functions of carbohydrate-active enzymes in family GH65 : diversity and application,” APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 108, no. 1, 2024.
@article{01JGXF73X603TF1KE60F76CJWV,
  abstract     = {{Glycoside Hydrolase family 65 (GH65) is a unique family of carbohydrate-active enzymes. It is the first protein family to bring together glycoside hydrolases, glycoside phosphorylases and glycosyltransferases, thereby spanning a broad range of reaction types. These enzymes catalyze the hydrolysis, reversible phosphorolysis or synthesis of various alpha-glucosides, typically alpha-glucobioses or their derivatives. In this review, we present a comprehensive overview of the diverse reaction types and substrate specificities found in family GH65. We describe the determinants that control this remarkable diversity, as well as the applications of GH65 enzymes for carbohydrate synthesis. center dot GH65 is the first CAZy family to contain hydrolases, phosphorylases and transferases center dot Distinct residues and loops are determinants of substrate specificity in family GH65 center dot GH65 enzymes hold strong potential for carbohydrate synthesis via coupled reactions}},
  articleno    = {{476}},
  author       = {{De Beul, Emma and Franceus, Jorick and Desmet, Tom}},
  issn         = {{0175-7598}},
  journal      = {{APPLIED MICROBIOLOGY AND BIOTECHNOLOGY}},
  keywords     = {{Glycoside Hydrolase family 65,Carbohydrate-active enzymes,Glycoside hydrolases,Glycoside phosphorylases,Glycosyltransferases,Specificity determinants,One-pot cascade reactions,LACTOBACILLUS-ACIDOPHILUS NCFM,BACILLUS-STEAROTHERMOPHILUS SK-1,TREHALOSE PHOSPHORYLASE,MALTOSE PHOSPHORYLASE,ACID TREHALASE,THERMOANAEROBACTER-BROCKII,ENZYMATIC-SYNTHESIS,KOJIBIOSE PHOSPHORYLASE,REVERSE PHOSPHOROLYSIS,SUBSTRATE-SPECIFICITY}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{22}},
  title        = {{The many functions of carbohydrate-active enzymes in family GH65 : diversity and application}},
  url          = {{http://doi.org/10.1007/s00253-024-13301-4}},
  volume       = {{108}},
  year         = {{2024}},
}
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