Respiratory viruses in patients with hematological malignancy in boreal autumn/winter 2023–2024 : EPICOVIDEHA-EPIFLUEHA report
- Author
- Jon Salmanton‐García, Francesco Marchesi, Milan Navrátil, Klára Piukovics, Maria Ilaria del Principe, Marianna Criscuolo, Yavuz M. Bilgin, Nicola S. Fracchiolla, Antonio Vena, Alessandra Romano, Iker Falces‐Romero, Nicola Sgherza, Inmaculada Heras‐Fernando, Monika M. Biernat, Verena Petzer, Pavel Žák, Barbora Weinbergerová, Michail Samarkos, Nurettin Erben, Jens Van Praet (UGent) , Alberto López‐García, Jorge Labrador, Tobias Lahmer, Ľuboš Drgoňa, Maria Merelli, Annarosa Cuccaro, Sonia Martín‐Pérez, Julio Dávila‐Valls, Francesca Farina, Chiara Cattaneo, László Imre Pinczés, Ferenc Magyari, Ildefonso Espigado, Caterina Buquicchio, Donald C. Vinh, Igor Stoma, Martin Čerňan, Lucia Prezioso, Mario Virgilio Papa, Gaëtan Plantefeve, Reham Abdelaziz Khedr, Josip Batinić, Gabriele Magliano, Simge Erdem, Sofya Khostelidi, Natasha Čolović, Davide Nappi, Patricia García‐Ramírez, Jakub Góra, Marta Callejas‐Charavia, Jędrzej Tłusty, Martijn Bakker, Elwira Wojtyniak, Darko Antić, Agnieszka Magdziak, Michelina Dargenio, Larisa Idrizović, Nikola Pantić, Zlate Stojanoski, Noha Eisa, Vladimir Otašević, Monia Marchetti, Erica Mackenzie, Carolina Garcia‐Vidal, Avinash Aujayeb, Ahlam Almasari, Carolina Miranda‐Castillo, Eleni Gavriilaki, Nicola Coppola, Alessandro Busca, Tatjana Adžić‐Vukičević, Martin Schönlein, Ditte Stampe Hersby, Stefanie K. Gräfe, Andreas Glenthøj, Tommaso Francesco Aiello, Milche Cvetanoski, Mirjana Mitrović, Claudio Cerchione, Romane Prin, Gina Varricchio, Elena Arellano, Raúl Córdoba, Jiří Mayer, Benjamín Víšek, Dominik Wolf, Amalia N. Anastasopoulou, Mario Delia, Pellegrino Musto, Dario Leotta, Martina Bavastro, Alessandro Limongelli, Mariarita Sciumè, Lukas van den Ven, Luana Fianchi, Sara Caterina Brunetti, Joanna Drozd‐Sokołowska, Anna Dąbrowska‐Iwanicka, Oliver A. Cornely and Livio Pagano
- Organization
- Abstract
- Community-acquired respiratory viral infections (CARV) significantly impact patients with hematological malignancies (HM), leading to high morbidity and mortality. However, large-scale, real-world data on CARV in these patients is limited. This study analyzed data from the EPICOVIDEHA-EPIFLUEHA registry, focusing on patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season. The study assessed epidemiology, clinical characteristics, risk factors, and outcomes. The study examined 1312 patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season. Of these, 59.5% required hospitalization, with 13.5% needing ICU admission. The overall mortality rate was 10.6%, varying by virus: parainfluenza (21.3%), influenza (8.8%), metapneumovirus (7.1%), RSV (5.9%), or SARS-CoV-2 (5.0%). Poor outcomes were significantly associated with smoking history, severe lymphopenia, secondary bacterial infections, and ICU admission. This study highlights the severe risk CARV poses to patients with HM, especially those undergoing active treatment. The high rates of hospitalization and mortality stress the need for better prevention, early diagnosis, and targeted therapies. Given the severe outcomes with certain viruses like parainfluenza, tailored strategies are crucial to improving patient outcomes in future CARV seasons.
- Keywords
- antiviral therapy, community-acquired respiratory viral infection, hematological malignancy, secondary infection, vaccine coverage, CELL TRANSPLANT RECIPIENTS, PARAINFLUENZA VIRUS, INFECTIONS, INFLUENZA, COVID-19, MANAGEMENT, LEUKEMIA, METAPNEUMOVIRUS, PREVENTION, GUIDELINES
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01JG47N2B1PF5EK0YR8Y1VEXGB
- MLA
- Salmanton‐García, Jon, et al. “Respiratory Viruses in Patients with Hematological Malignancy in Boreal Autumn/Winter 2023–2024 : EPICOVIDEHA-EPIFLUEHA Report.” AMERICAN JOURNAL OF HEMATOLOGY, vol. 100, no. 3, 2025, pp. 358–74, doi:10.1002/ajh.27565.
- APA
- Salmanton‐García, J., Marchesi, F., Navrátil, M., Piukovics, K., del Principe, M. I., Criscuolo, M., … Pagano, L. (2025). Respiratory viruses in patients with hematological malignancy in boreal autumn/winter 2023–2024 : EPICOVIDEHA-EPIFLUEHA report. AMERICAN JOURNAL OF HEMATOLOGY, 100(3), 358–374. https://doi.org/10.1002/ajh.27565
- Chicago author-date
- Salmanton‐García, Jon, Francesco Marchesi, Milan Navrátil, Klára Piukovics, Maria Ilaria del Principe, Marianna Criscuolo, Yavuz M. Bilgin, et al. 2025. “Respiratory Viruses in Patients with Hematological Malignancy in Boreal Autumn/Winter 2023–2024 : EPICOVIDEHA-EPIFLUEHA Report.” AMERICAN JOURNAL OF HEMATOLOGY 100 (3): 358–74. https://doi.org/10.1002/ajh.27565.
- Chicago author-date (all authors)
- Salmanton‐García, Jon, Francesco Marchesi, Milan Navrátil, Klára Piukovics, Maria Ilaria del Principe, Marianna Criscuolo, Yavuz M. Bilgin, Nicola S. Fracchiolla, Antonio Vena, Alessandra Romano, Iker Falces‐Romero, Nicola Sgherza, Inmaculada Heras‐Fernando, Monika M. Biernat, Verena Petzer, Pavel Žák, Barbora Weinbergerová, Michail Samarkos, Nurettin Erben, Jens Van Praet, Alberto López‐García, Jorge Labrador, Tobias Lahmer, Ľuboš Drgoňa, Maria Merelli, Annarosa Cuccaro, Sonia Martín‐Pérez, Julio Dávila‐Valls, Francesca Farina, Chiara Cattaneo, László Imre Pinczés, Ferenc Magyari, Ildefonso Espigado, Caterina Buquicchio, Donald C. Vinh, Igor Stoma, Martin Čerňan, Lucia Prezioso, Mario Virgilio Papa, Gaëtan Plantefeve, Reham Abdelaziz Khedr, Josip Batinić, Gabriele Magliano, Simge Erdem, Sofya Khostelidi, Natasha Čolović, Davide Nappi, Patricia García‐Ramírez, Jakub Góra, Marta Callejas‐Charavia, Jędrzej Tłusty, Martijn Bakker, Elwira Wojtyniak, Darko Antić, Agnieszka Magdziak, Michelina Dargenio, Larisa Idrizović, Nikola Pantić, Zlate Stojanoski, Noha Eisa, Vladimir Otašević, Monia Marchetti, Erica Mackenzie, Carolina Garcia‐Vidal, Avinash Aujayeb, Ahlam Almasari, Carolina Miranda‐Castillo, Eleni Gavriilaki, Nicola Coppola, Alessandro Busca, Tatjana Adžić‐Vukičević, Martin Schönlein, Ditte Stampe Hersby, Stefanie K. Gräfe, Andreas Glenthøj, Tommaso Francesco Aiello, Milche Cvetanoski, Mirjana Mitrović, Claudio Cerchione, Romane Prin, Gina Varricchio, Elena Arellano, Raúl Córdoba, Jiří Mayer, Benjamín Víšek, Dominik Wolf, Amalia N. Anastasopoulou, Mario Delia, Pellegrino Musto, Dario Leotta, Martina Bavastro, Alessandro Limongelli, Mariarita Sciumè, Lukas van den Ven, Luana Fianchi, Sara Caterina Brunetti, Joanna Drozd‐Sokołowska, Anna Dąbrowska‐Iwanicka, Oliver A. Cornely, and Livio Pagano. 2025. “Respiratory Viruses in Patients with Hematological Malignancy in Boreal Autumn/Winter 2023–2024 : EPICOVIDEHA-EPIFLUEHA Report.” AMERICAN JOURNAL OF HEMATOLOGY 100 (3): 358–374. doi:10.1002/ajh.27565.
- Vancouver
- 1.Salmanton‐García J, Marchesi F, Navrátil M, Piukovics K, del Principe MI, Criscuolo M, et al. Respiratory viruses in patients with hematological malignancy in boreal autumn/winter 2023–2024 : EPICOVIDEHA-EPIFLUEHA report. AMERICAN JOURNAL OF HEMATOLOGY. 2025;100(3):358–74.
- IEEE
- [1]J. Salmanton‐García et al., “Respiratory viruses in patients with hematological malignancy in boreal autumn/winter 2023–2024 : EPICOVIDEHA-EPIFLUEHA report,” AMERICAN JOURNAL OF HEMATOLOGY, vol. 100, no. 3, pp. 358–374, 2025.
@article{01JG47N2B1PF5EK0YR8Y1VEXGB,
abstract = {{Community-acquired respiratory viral infections (CARV) significantly impact patients with hematological malignancies (HM), leading to high morbidity and mortality. However, large-scale, real-world data on CARV in these patients is limited. This study analyzed data from the EPICOVIDEHA-EPIFLUEHA registry, focusing on patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season. The study assessed epidemiology, clinical characteristics, risk factors, and outcomes. The study examined 1312 patients with HM diagnosed with CARV during the 2023-2024 autumn-winter season. Of these, 59.5% required hospitalization, with 13.5% needing ICU admission. The overall mortality rate was 10.6%, varying by virus: parainfluenza (21.3%), influenza (8.8%), metapneumovirus (7.1%), RSV (5.9%), or SARS-CoV-2 (5.0%). Poor outcomes were significantly associated with smoking history, severe lymphopenia, secondary bacterial infections, and ICU admission. This study highlights the severe risk CARV poses to patients with HM, especially those undergoing active treatment. The high rates of hospitalization and mortality stress the need for better prevention, early diagnosis, and targeted therapies. Given the severe outcomes with certain viruses like parainfluenza, tailored strategies are crucial to improving patient outcomes in future CARV seasons.}},
author = {{Salmanton‐García, Jon and Marchesi, Francesco and Navrátil, Milan and Piukovics, Klára and del Principe, Maria Ilaria and Criscuolo, Marianna and Bilgin, Yavuz M. and Fracchiolla, Nicola S. and Vena, Antonio and Romano, Alessandra and Falces‐Romero, Iker and Sgherza, Nicola and Heras‐Fernando, Inmaculada and Biernat, Monika M. and Petzer, Verena and Žák, Pavel and Weinbergerová, Barbora and Samarkos, Michail and Erben, Nurettin and Van Praet, Jens and López‐García, Alberto and Labrador, Jorge and Lahmer, Tobias and Drgoňa, Ľuboš and Merelli, Maria and Cuccaro, Annarosa and Martín‐Pérez, Sonia and Dávila‐Valls, Julio and Farina, Francesca and Cattaneo, Chiara and Pinczés, László Imre and Magyari, Ferenc and Espigado, Ildefonso and Buquicchio, Caterina and Vinh, Donald C. and Stoma, Igor and Čerňan, Martin and Prezioso, Lucia and Papa, Mario Virgilio and Plantefeve, Gaëtan and Khedr, Reham Abdelaziz and Batinić, Josip and Magliano, Gabriele and Erdem, Simge and Khostelidi, Sofya and Čolović, Natasha and Nappi, Davide and García‐Ramírez, Patricia and Góra, Jakub and Callejas‐Charavia, Marta and Tłusty, Jędrzej and Bakker, Martijn and Wojtyniak, Elwira and Antić, Darko and Magdziak, Agnieszka and Dargenio, Michelina and Idrizović, Larisa and Pantić, Nikola and Stojanoski, Zlate and Eisa, Noha and Otašević, Vladimir and Marchetti, Monia and Mackenzie, Erica and Garcia‐Vidal, Carolina and Aujayeb, Avinash and Almasari, Ahlam and Miranda‐Castillo, Carolina and Gavriilaki, Eleni and Coppola, Nicola and Busca, Alessandro and Adžić‐Vukičević, Tatjana and Schönlein, Martin and Hersby, Ditte Stampe and Gräfe, Stefanie K. and Glenthøj, Andreas and Aiello, Tommaso Francesco and Cvetanoski, Milche and Mitrović, Mirjana and Cerchione, Claudio and Prin, Romane and Varricchio, Gina and Arellano, Elena and Córdoba, Raúl and Mayer, Jiří and Víšek, Benjamín and Wolf, Dominik and Anastasopoulou, Amalia N. and Delia, Mario and Musto, Pellegrino and Leotta, Dario and Bavastro, Martina and Limongelli, Alessandro and Sciumè, Mariarita and van den Ven, Lukas and Fianchi, Luana and Brunetti, Sara Caterina and Drozd‐Sokołowska, Joanna and Dąbrowska‐Iwanicka, Anna and Cornely, Oliver A. and Pagano, Livio}},
issn = {{0361-8609}},
journal = {{AMERICAN JOURNAL OF HEMATOLOGY}},
keywords = {{antiviral therapy,community-acquired respiratory viral infection,hematological malignancy,secondary infection,vaccine coverage,CELL TRANSPLANT RECIPIENTS,PARAINFLUENZA VIRUS,INFECTIONS,INFLUENZA,COVID-19,MANAGEMENT,LEUKEMIA,METAPNEUMOVIRUS,PREVENTION,GUIDELINES}},
language = {{eng}},
number = {{3}},
pages = {{358--374}},
title = {{Respiratory viruses in patients with hematological malignancy in boreal autumn/winter 2023–2024 : EPICOVIDEHA-EPIFLUEHA report}},
url = {{http://doi.org/10.1002/ajh.27565}},
volume = {{100}},
year = {{2025}},
}
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