@article{01JEBHGMTPW1SSGG7QXF59JMX1,
  abstract     = {{Objectives: To evaluate the value of (dynamic) contrast-enhanced MRI for the diagnosis and follow-up of central cartilage tumors (CCT) of the proximal humerus, distal femur and proximal tibia. Materials & methods: 97 patients (44 +/- 11 years, 31men) with a CCT (histopathologically proven and/or > 2 years follow-up (5 +/- 3 years)) were retrospectively/consecutively included at the Ghent University Hospital (Belgium, 2003-2021). Thickness of the enhancing rim and dynamic contrast-enhanced MRI parameters of the entire tumor were calculated. Tumor volumes were calculated to assess tumor growth. Significant differences between enchondromas, atypical cartilaginous tumors, high-grade chondrosarcomas, tumors with and without growth at follow-up were evaluated and ROC-curves were analyzed. Results: A significant difference (p = 0.015) existed in enhancing rim thickness between high-grade chondrosarcomas and other groups. A ROC-curve with an AUC of 0.89 and cut-off value of 1.2 mm had a sensitivity of 100 % and a specificity of 64 % to identify high-grade chondrosarcomas. A significant correlation was found between the relative maximal enhancement (Rel-Emax) of the whole tumor compared to muscle and the absolute growth rate (rho = 0.75, p < 0.001). Lesions with a Rel-Emax < 1 remained stable or showed regression during follow-up (mean-0.1 +/- 0.3 ml/year). Lesions with a Rel-Emax between 1 and 2 showed little growth (mean + 0.2 +/- 0.2 ml/year), and lesions with a Rel-Emax > 2 had the highest growth rate (mean 0.4 +/- 0.2 ml/year). Conclusion: A thick enhancing rim > 1.2 mm has a high sensitivity to detect high-grade chondrosarcomas. The higher the Rel-Emax of the whole tumor compared to muscle, the higher the growth rate of a CCT.}},
  articleno    = {{111860}},
  author       = {{Lejoly, Maryse and Van Den Berghe, Thomas and Delbare, Felix and Huysse, Wouter and Creytens, David and Sys, Gwen and Verstraete, Koenraad}},
  issn         = {{0720-048X}},
  journal      = {{EUROPEAN JOURNAL OF RADIOLOGY}},
  keywords     = {{Chondrosarcoma,Chondroma,Magnetic Resonance Imaging,Multiparametric Magnetic Resonance Imaging,Bone,Bones- and bone neoplasms,ENCHONDROMA}},
  language     = {{eng}},
  pages        = {{11}},
  title        = {{Evaluation of the value of dynamic contrast-enhanced MRI for the diagnosis and follow-up of central cartilage tumors}},
  url          = {{http://doi.org/10.1016/j.ejrad.2024.111860}},
  volume       = {{183}},
  year         = {{2025}},
}

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