@article{01JE3YEY0RGRF6TKR1MYMRWPGE,
  abstract     = {{Background
Mycotoxins, fungal metabolites prevalent in many foods, are recognized for their role in carcinogenesis, especially when interacting with oncogenic viruses.

Objectives
This scoping review synthesizes current evidence on the human cancer risk associated with mycotoxin exposure and oncogenic virus infections.

Methods
Searches were conducted on PubMed, Embase, and Web of Science. Studies were selected based on the PECOS framework. Data extraction involved narrative and qualitative presentation of findings, with meta-analysis where feasible. Risk of bias and outcome quality were assessed using the OHAT tool and GRADE approach.

Results
From 25 included studies, 18 focused on aflatoxins and hepatitis viruses in hepatocellular carcinoma (HCC). Four studies examined aflatoxin B1 (AFB1) and human papilloma virus (HPV) in cervical cancer, while three investigated AFB1 with Epstein-Barr virus (EBV) in lymphomagenesis. The review highlights a significant synergistic effect between AFB1 and hepatitis B and C viruses in HCC development. Significant interactions between AFB1 and HPV, as well as AFB1 and EBV, were observed, but further research is needed.

Conclusions
The synergistic impact of mycotoxins and oncogenic viruses is a critical public health concern. Future research, especially prospective cohort studies and investigations into molecular mechanisms, is essential to address this complex issue.}},
  author       = {{Mouchtaris Michailidis, Thanos and De Saeger, Sarah and Khoueiry, Rita and Odongo, Grace A. and Bader, Yasmine and Dhaenens, Maarten and Herceg, Zdenko and De Boevre, Marthe}},
  issn         = {{1040-8398}},
  journal      = {{CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION}},
  keywords     = {{Aflatoxin,oncogenic viruses,carcinogenesis,exposure,mycotoxins,cancer,HEPATITIS-B-VIRUS,AFLATOXIN B-1 EXPOSURE,HEPATOCELLULAR-CARCINOMA,BREAST-CANCER,FUMONISIN B-1,OCHRATOXIN-A,HEPG2 CELLS,RISK,INFECTION,MECHANISMS}},
  language     = {{eng}},
  number       = {{25}},
  pages        = {{5008--5026}},
  title        = {{The interplay of dietary mycotoxins and oncogenic viruses toward human carcinogenesis : a scoping review}},
  url          = {{http://doi.org/10.1080/10408398.2024.2414828}},
  volume       = {{65}},
  year         = {{2025}},
}

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