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Enhancing the trustworthiness of pain research : a call to action

Neil E. O’Connell, Joletta Belton, Geert Crombez (UGent) , Christopher Eccleston, Emma Fisher, Michael C. Ferraro, Anna Hood, Francis Keefe, Roger Knaggs, Emma Norris, et al.
(2025) JOURNAL OF PAIN. 28.
Author
Organization
Abstract
The personal, social and economic burden of chronic pain is enormous. Tremendous research efforts are being directed toward understanding, preventing, and managing chronic pain. Yet patients with chronic pain, clinicians and the public are sometimes poorly served by an evidence architecture that contains multiple structural weaknesses. These include incomplete research governance, a lack of diversity and inclusivity, inadequate stakeholder engagement, poor methodological rigour and incomplete reporting, a lack of data accessibility and transparency, and a failure to communicate findings with appropriate balance. These issues span pre-clinical research, clinical trials and systematic reviews and impact the development of clinical guidance and practice. Research misconduct and inauthentic data present a further critical risk. Combined, they increase uncertainty in this highly challenging area of study and practice, drive the provision of low value care, increase costs and impede the discovery of more effective solutions.
Keywords
Trustworthiness, Integrity, Equity, Engagement, Transparency, Rigour, ID TRIALS, PUBLICATIONS, JOURNALS, CHILDREN, HEALTH

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MLA
O’Connell, Neil E., et al. “Enhancing the Trustworthiness of Pain Research : A Call to Action.” JOURNAL OF PAIN, vol. 28, 2025, doi:10.1016/j.jpain.2024.104736.
APA
O’Connell, N. E., Belton, J., Crombez, G., Eccleston, C., Fisher, E., Ferraro, M. C., … Williams, A. C. de C. (2025). Enhancing the trustworthiness of pain research : a call to action. JOURNAL OF PAIN, 28. https://doi.org/10.1016/j.jpain.2024.104736
Chicago author-date
O’Connell, Neil E., Joletta Belton, Geert Crombez, Christopher Eccleston, Emma Fisher, Michael C. Ferraro, Anna Hood, et al. 2025. “Enhancing the Trustworthiness of Pain Research : A Call to Action.” JOURNAL OF PAIN 28. https://doi.org/10.1016/j.jpain.2024.104736.
Chicago author-date (all authors)
O’Connell, Neil E., Joletta Belton, Geert Crombez, Christopher Eccleston, Emma Fisher, Michael C. Ferraro, Anna Hood, Francis Keefe, Roger Knaggs, Emma Norris, Tonya M. Palermo, Gisèle Pickering, Esther Pogatzki-Zahn, Andrew SC Rice, Georgia Richards, Daniel Segelcke, Keith M. Smart, Nadia Soliman, Gavin Stewart, Thomas Tölle, Dennis Turk, Jan Vollert, Elaine Wainwright, Jack Wilkinson, and Amanda C.de C. Williams. 2025. “Enhancing the Trustworthiness of Pain Research : A Call to Action.” JOURNAL OF PAIN 28. doi:10.1016/j.jpain.2024.104736.
Vancouver
1.
O’Connell NE, Belton J, Crombez G, Eccleston C, Fisher E, Ferraro MC, et al. Enhancing the trustworthiness of pain research : a call to action. JOURNAL OF PAIN. 2025;28.
IEEE
[1]
N. E. O’Connell et al., “Enhancing the trustworthiness of pain research : a call to action,” JOURNAL OF PAIN, vol. 28, 2025.
@article{01JD70BM3JD0KCDRTGGMRTT7NA,
  abstract     = {{The personal, social and economic burden of chronic pain is enormous. Tremendous research efforts are being directed toward understanding, preventing, and managing chronic pain. Yet patients with chronic pain, clinicians and the public are sometimes poorly served by an evidence architecture that contains multiple structural weaknesses. These include incomplete research governance, a lack of diversity and inclusivity, inadequate stakeholder engagement, poor methodological rigour and incomplete reporting, a lack of data accessibility and transparency, and a failure to communicate findings with appropriate balance. These issues span pre-clinical research, clinical trials and systematic reviews and impact the development of clinical guidance and practice. Research misconduct and inauthentic data present a further critical risk. Combined, they increase uncertainty in this highly challenging area of study and practice, drive the provision of low value care, increase costs and impede the discovery of more effective solutions.}},
  articleno    = {{104736}},
  author       = {{O’Connell, Neil E. and Belton, Joletta and Crombez, Geert and Eccleston, Christopher and Fisher, Emma and Ferraro, Michael C. and Hood, Anna and Keefe, Francis and Knaggs, Roger and Norris, Emma and Palermo, Tonya M. and Pickering, Gisèle and Pogatzki-Zahn, Esther and Rice, Andrew SC and Richards, Georgia and Segelcke, Daniel and Smart, Keith M. and Soliman, Nadia and Stewart, Gavin and Tölle, Thomas and Turk, Dennis and Vollert, Jan and Wainwright, Elaine and Wilkinson, Jack and Williams, Amanda C.de C.}},
  issn         = {{1526-5900}},
  journal      = {{JOURNAL OF PAIN}},
  keywords     = {{Trustworthiness,Integrity,Equity,Engagement,Transparency,Rigour,ID TRIALS,PUBLICATIONS,JOURNALS,CHILDREN,HEALTH}},
  language     = {{eng}},
  pages        = {{11}},
  title        = {{Enhancing the trustworthiness of pain research : a call to action}},
  url          = {{http://doi.org/10.1016/j.jpain.2024.104736}},
  volume       = {{28}},
  year         = {{2025}},
}
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