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The healthy canine brain model : non-invasive transcranial brain stimulation in the canine species

Sofie Salden (UGent) , Anouck Haverbeke (UGent) , Kathelijne Peremans (UGent) , Yangfeng Xu, Jimmy Saunders (UGent) and Chris Baeken (UGent)
(2024) European Veterinary Congress of Behavioural Medicine and Animal Welfare, 6th annual meeting, Abstracts. p.127-127
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Abstract
The canine species holds potential as a valid natural translational animal model for non-invasive brain stimulation (NIBS) research due to its relevance in modelling human neurological and neuropsychiatric disorders. Moreover, NIBS, particularly repetitive transcranial magnetic stimulation (rTMS), holds promise as a treatment for dog patients with behavioural disorders, emphasizing the interdisciplinary nature of investigating this modality. This review explores the applicability, feasibility, neuronal effects, and durability of accelerated high-frequency rTMS (aHF-rTMS) in healthy dogs and its potential application in veterinary medicine. Results demonstrate that aHF-rTMS is a viable method to use in the canine brain model, revealing consistent stimulation of left frontal neural activity with transient effects, and normalization after three months (Dockx et al., 2018, 2017; Xu et al., 2022b). Neurotransmitter studies revealed influences on both serotonergic and dopaminergic systems, with faster and less dose-dependent effects observed for dopamine compared to serotonin (Xu et al., 2023, 2022a). These findings suggest therapeutic potential of aHF-rTMS for canine behavioural disorders, supported by recent clinical trials showing behavioural improvements mirroring human medicine observations (Salden et al., in preparation). Further research is warranted to refine protocols, understand long-term effects, and establish criteria for patient selection. This will maximize the efficacy of aHF-rTMS in treating canine behavioural disorders, while also further bolstering the canine brain model for human NIBS research.

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MLA
Salden, Sofie, et al. “The Healthy Canine Brain Model : Non-Invasive Transcranial Brain Stimulation in the Canine Species.” European Veterinary Congress of Behavioural Medicine and Animal Welfare, 6th Annual Meeting, Abstracts, 2024, pp. 127–127.
APA
Salden, S., Haverbeke, A., Peremans, K., Xu, Y., Saunders, J., & Baeken, C. (2024). The healthy canine brain model : non-invasive transcranial brain stimulation in the canine species. European Veterinary Congress of Behavioural Medicine and Animal Welfare, 6th Annual Meeting, Abstracts, 127–127.
Chicago author-date
Salden, Sofie, Anouck Haverbeke, Kathelijne Peremans, Yangfeng Xu, Jimmy Saunders, and Chris Baeken. 2024. “The Healthy Canine Brain Model : Non-Invasive Transcranial Brain Stimulation in the Canine Species.” In European Veterinary Congress of Behavioural Medicine and Animal Welfare, 6th Annual Meeting, Abstracts, 127–127.
Chicago author-date (all authors)
Salden, Sofie, Anouck Haverbeke, Kathelijne Peremans, Yangfeng Xu, Jimmy Saunders, and Chris Baeken. 2024. “The Healthy Canine Brain Model : Non-Invasive Transcranial Brain Stimulation in the Canine Species.” In European Veterinary Congress of Behavioural Medicine and Animal Welfare, 6th Annual Meeting, Abstracts, 127–127.
Vancouver
1.
Salden S, Haverbeke A, Peremans K, Xu Y, Saunders J, Baeken C. The healthy canine brain model : non-invasive transcranial brain stimulation in the canine species. In: European Veterinary Congress of Behavioural Medicine and Animal Welfare, 6th annual meeting, Abstracts. 2024. p. 127–127.
IEEE
[1]
S. Salden, A. Haverbeke, K. Peremans, Y. Xu, J. Saunders, and C. Baeken, “The healthy canine brain model : non-invasive transcranial brain stimulation in the canine species,” in European Veterinary Congress of Behavioural Medicine and Animal Welfare, 6th annual meeting, Abstracts, Paris, 2024, pp. 127–127.
@inproceedings{01JCQFZJNA2VFVSW2JTBKYX1BK,
  abstract     = {{The canine species holds potential as a valid natural translational animal model for non-invasive brain stimulation (NIBS) research due to its relevance in modelling human neurological and neuropsychiatric disorders. Moreover, NIBS, particularly repetitive transcranial magnetic stimulation (rTMS), holds promise as a treatment for dog patients with behavioural disorders, emphasizing the interdisciplinary nature of investigating this modality. This review explores the applicability, feasibility, neuronal effects, and durability of accelerated high-frequency rTMS (aHF-rTMS) in healthy dogs and its potential application in veterinary medicine. Results demonstrate that aHF-rTMS is a viable method to use in the canine brain model, revealing consistent stimulation of left frontal neural activity with transient effects, and normalization after three months (Dockx et al., 2018, 2017; Xu et al., 2022b). Neurotransmitter studies revealed influences on both serotonergic and dopaminergic systems, with faster and less dose-dependent effects observed for dopamine compared to serotonin (Xu et al., 2023, 2022a). These findings suggest therapeutic potential of aHF-rTMS for canine behavioural disorders, supported by recent clinical trials showing behavioural improvements mirroring human medicine observations (Salden et al., in preparation). Further research is warranted to refine protocols, understand long-term effects, and establish criteria for patient selection. This will maximize the efficacy of aHF-rTMS in treating canine behavioural disorders, while also further bolstering the canine brain model for human NIBS research.}},
  author       = {{Salden, Sofie and Haverbeke, Anouck and Peremans, Kathelijne and Xu, Yangfeng and Saunders, Jimmy and Baeken, Chris}},
  booktitle    = {{European Veterinary Congress of Behavioural Medicine and Animal Welfare, 6th annual meeting, Abstracts}},
  language     = {{eng}},
  location     = {{Paris}},
  pages        = {{127--127}},
  title        = {{The healthy canine brain model : non-invasive transcranial brain stimulation in the canine species}},
  year         = {{2024}},
}