@article{01JCPBT94QBTDTMQ24E7EY3AVR,
  abstract     = {{Introduction: Patients with congenital heart disease (ConHD) are at increased risk for adverse cardiac events. Predicting long-term outcomes and guidance of patient management might benefit from a range of (new) biomarkers. This is a rapidly evolving field with potentially large consequences for clinical decision making. With a systematic review of available biomarkers in ConHD we identified the clinical role of these markers, knowledge gaps and future research directions.

Methods: We systematically reviewed the literature on associations between blood biomarkers and outcome measures (mortality or composite adverse outcomes in patients with ConHD.

Results: The inclusion criteria were met by 102 articles. Biomarkers assessed in more than studies are discussed in the main text, those studied in 3 or less studies are summarized in the supplement. Thus, we discuss 15 biomarkers from 92 studies. These biomarkers were studied in 32,399 / 10,735 patients for the association with mortality and composite adverse outcomes, respectively. Biomarkers that were studied most and had statistically significant associations with mortality or composite adverse outcomes were (NT-pro)BNP, MELD-XI score, Hs-CRP, creatinine, albumin and sodium. Most of these biomarkers are involved in intracardiac processes associated with inflammation or are markers of renal function.

Conclusion: For (NT-pro)BNP, clinical value for prediction of mortality and composite adverse outcomes in adult and paediatric ConHD has been shown. For MELD-XI, hs-CRP, albumin, creatinine, sodium, RDW, and GDF-15, correlations with mortality and composite adverse outcomes have been demonstrated in patient groups with mixed types of ConHD, but clinical utility needs additional exploration.}},
  articleno    = {{132723}},
  author       = {{van Genuchten, W.J. and Averesch, H. and van Dieren, Q.M. and Bonnet, D. and Odemarsky, M. and Beghetti, M. and Roos-Hesselink, J.W. and Reinhardt, Z. and Male, C. and Naumburg, E. and Boersma, E. and De Wolf, Daniël and Helbing, W.A. and Cardiology Expert Group of the connect4children (c4c) network, [missing]}},
  issn         = {{0167-5273}},
  journal      = {{INTERNATIONAL JOURNAL OF CARDIOLOGY}},
  keywords     = {{Biomarkers,Prognosis,Congenital heart disease,Hs-TnT,CRP,ST-2,GDF-15,RDW,Albumin,Creatinine,Gal-3,Norepinephrine,BNP,NT-proBNP,MELD-XI,CELL DISTRIBUTION WIDTH,PULMONARY ARTERIAL-HYPERTENSION,BRAIN NATRIURETIC PEPTIDE,ANGIOTENSIN-ALDOSTERONE SYSTEM,AUTONOMIC NERVOUS ACTIVITY,DIFFERENTIATION FACTOR 15,SENSITIVITY TROPONIN-T,HUMAN SERUM-ALBUMIN,C-REACTIVE PROTEIN,PROGNOSTIC VALUE}},
  language     = {{eng}},
  pages        = {{13}},
  title        = {{Clinical impact of circulating biomarkers in prediction of adverse cardiac events in patients with congenital heart disease. A systematic review}},
  url          = {{http://doi.org/10.1016/j.ijcard.2024.132723}},
  volume       = {{421}},
  year         = {{2025}},
}

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