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Foxtail millet bran dietary fibres foster in vitro beneficial gut microbes and metabolites while suppressing pathobionts

Qi Li, Xiaowen Wang, Chuanlong Ma (UGent) , Stanley Onyango, Weijie Wu, Haiyan Gao and Qiqiong Li
(2025) FOOD CHEMISTRY. 464(3).
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Abstract
Foxtail millet bran soluble dietary fibre (MBSDF) is a dietary compound with various bioactivities, potentially modulated by the gut microbiota. To elucidate this bioregulatory mechanism, this study focused on the structureal composition and in vitro fermentation characteristics of MBSDF. The results revealed that MBSDF has a molecular weight of 18.26 kDa. The main chain is connected through a glycosidic bond in the form of-*4)-alpha-DGlcp-(1-* 4)-(3-D-Xylp-(1-*, being branched by-*4, 6)-alpha-D-Glcp-(1-* O-6 and-*3, 4)-(3-D-Xylp-(1-* O 3 bonds. After 24 h fermentation, the carbohydrate utilisation rate reached 59.15 %, with a decreased molecular weight and monosaccharide composition molar mass ratio. Meanwhile, a increase was observed in the short-chain fatty acid, accompanied by an increased relative abundance of Faecalibacterium, Bifidobacterium and Lactobacillus and suppressed growth of pathogenic Enterococcus. Interestingly, the modulation of gut homeostasis probably occurs via butyrate metabolism pathway. Collectively, MBSDF can selectively regulate the gut microbiota and their metabolites.
Keywords
Soluble dietary fibre, Gut microbiota, In vitro fermentation, Metabolic function, Millet bran, Butyrate, CHAIN FATTY-ACIDS, POLYSACCHARIDE, FERMENTATION

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MLA
Li, Qi, et al. “Foxtail Millet Bran Dietary Fibres Foster in Vitro Beneficial Gut Microbes and Metabolites While Suppressing Pathobionts.” FOOD CHEMISTRY, vol. 464, no. 3, 2025, doi:10.1016/j.foodchem.2024.141933.
APA
Li, Q., Wang, X., Ma, C., Onyango, S., Wu, W., Gao, H., & Li, Q. (2025). Foxtail millet bran dietary fibres foster in vitro beneficial gut microbes and metabolites while suppressing pathobionts. FOOD CHEMISTRY, 464(3). https://doi.org/10.1016/j.foodchem.2024.141933
Chicago author-date
Li, Qi, Xiaowen Wang, Chuanlong Ma, Stanley Onyango, Weijie Wu, Haiyan Gao, and Qiqiong Li. 2025. “Foxtail Millet Bran Dietary Fibres Foster in Vitro Beneficial Gut Microbes and Metabolites While Suppressing Pathobionts.” FOOD CHEMISTRY 464 (3). https://doi.org/10.1016/j.foodchem.2024.141933.
Chicago author-date (all authors)
Li, Qi, Xiaowen Wang, Chuanlong Ma, Stanley Onyango, Weijie Wu, Haiyan Gao, and Qiqiong Li. 2025. “Foxtail Millet Bran Dietary Fibres Foster in Vitro Beneficial Gut Microbes and Metabolites While Suppressing Pathobionts.” FOOD CHEMISTRY 464 (3). doi:10.1016/j.foodchem.2024.141933.
Vancouver
1.
Li Q, Wang X, Ma C, Onyango S, Wu W, Gao H, et al. Foxtail millet bran dietary fibres foster in vitro beneficial gut microbes and metabolites while suppressing pathobionts. FOOD CHEMISTRY. 2025;464(3).
IEEE
[1]
Q. Li et al., “Foxtail millet bran dietary fibres foster in vitro beneficial gut microbes and metabolites while suppressing pathobionts,” FOOD CHEMISTRY, vol. 464, no. 3, 2025.
@article{01JCDH1FB6ZD8KZFMYV352Y07G,
  abstract     = {{Foxtail millet bran soluble dietary fibre (MBSDF) is a dietary compound with various bioactivities, potentially modulated by the gut microbiota. To elucidate this bioregulatory mechanism, this study focused on the structureal composition and in vitro fermentation characteristics of MBSDF. The results revealed that MBSDF has a molecular weight of 18.26 kDa. The main chain is connected through a glycosidic bond in the form of-*4)-alpha-DGlcp-(1-* 4)-(3-D-Xylp-(1-*, being branched by-*4, 6)-alpha-D-Glcp-(1-* O-6 and-*3, 4)-(3-D-Xylp-(1-* O 3 bonds. After 24 h fermentation, the carbohydrate utilisation rate reached 59.15 %, with a decreased molecular weight and monosaccharide composition molar mass ratio. Meanwhile, a increase was observed in the short-chain fatty acid, accompanied by an increased relative abundance of Faecalibacterium, Bifidobacterium and Lactobacillus and suppressed growth of pathogenic Enterococcus. Interestingly, the modulation of gut homeostasis probably occurs via butyrate metabolism pathway. Collectively, MBSDF can selectively regulate the gut microbiota and their metabolites.}},
  articleno    = {{141933}},
  author       = {{Li, Qi and Wang, Xiaowen and Ma, Chuanlong and Onyango, Stanley and Wu, Weijie and Gao, Haiyan and Li, Qiqiong}},
  issn         = {{0308-8146}},
  journal      = {{FOOD CHEMISTRY}},
  keywords     = {{Soluble dietary fibre,Gut microbiota,In vitro fermentation,Metabolic function,Millet bran,Butyrate,CHAIN FATTY-ACIDS,POLYSACCHARIDE,FERMENTATION}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{13}},
  title        = {{Foxtail millet bran dietary fibres foster in vitro beneficial gut microbes and metabolites while suppressing pathobionts}},
  url          = {{http://doi.org/10.1016/j.foodchem.2024.141933}},
  volume       = {{464}},
  year         = {{2025}},
}
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