Did we overreact? Insights on COVID-19 disease and vaccination in a large cohort of immune-mediated inflammatory disease patients during sequential phases of the pandemic (the BELCOMID study)
- Author
- Jeroen Geldof (UGent) , Marie Truyens (UGent) , João Sabino, Marc Ferrante, Jo Lambert (UGent) , Hilde Lapeere (UGent) , Tom Hillary, An Van Laethem, Kurt de Vlam, Patrick Verschueren, Triana Lobatón Ortega (UGent) , Elizaveta Padalko (UGent) and Séverine Vermeire
- Organization
- Abstract
- Introduction: As the COVID-19 pandemic becomes an endemic state, still many questions remain regarding the risks and impact of SARS-CoV-2 infection and vaccination in patients with immune-mediated inflammatory diseases (IMIDs) who were excluded from the phase 3 COVID-19 vaccination trials. Methods: The BELCOMID study collected patient data and serological samples from a large, multicentric IMID patient cohort that was prospectively followed during sequential stages of the pandemic. Patients were stratified according to vaccination status into five groups across three sampling periods. Interactions between SARS-CoV-2 infection, COVID-19 vaccination status, IMID-treatment modalities and IMID course were explored. Results: In total, 2165 patients with IBD, a dermatological or rheumatological IMID participated. SARS-CoV-2 infection rates increased over the course of the pandemic and were highest in IMID patients that had refused every vaccine. After baseline COVID-19 vaccination, serologic spike (S)-antibody responses were attenuated by particular types of immune-modulating treatment: anti-TNF, rituximab, JAKi, systemic steroids, combined biologic/immunomodulator treatment. Nonetheless, S-antibody concentration increased progressively in patients who received a booster vaccination, reaching 100% seroconversion rate in patients who had received two booster vaccines. Previous SARS-CoV-2 infection was found as a predictor of higher S-antibody response. Patients who had refused every vaccine showed the lowest rates of S-seroconversion (53.8%). Multiple logistic regression did not identify previous SARS-CoV-2 infection as a risk factor for IMID flare-up. Furthermore, no increased risk of IMID flare-up was found with booster vaccination. Conclusions: Altogether, the BELCOMID study provides evidence for the efficacy and safety of COVID-19 vaccination and confirms the importance of repeated booster vaccination in IMID patients.
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Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-01JAZ232G9CT1AESHTHV99SFD7
- MLA
- Geldof, Jeroen, et al. “Did We Overreact? Insights on COVID-19 Disease and Vaccination in a Large Cohort of Immune-Mediated Inflammatory Disease Patients during Sequential Phases of the Pandemic (the BELCOMID Study).” VACCINES, vol. 12, no. 10, 2024, doi:10.3390/vaccines12101157.
- APA
- Geldof, J., Truyens, M., Sabino, J., Ferrante, M., Lambert, J., Lapeere, H., … Vermeire, S. (2024). Did we overreact? Insights on COVID-19 disease and vaccination in a large cohort of immune-mediated inflammatory disease patients during sequential phases of the pandemic (the BELCOMID study). VACCINES, 12(10). https://doi.org/10.3390/vaccines12101157
- Chicago author-date
- Geldof, Jeroen, Marie Truyens, João Sabino, Marc Ferrante, Jo Lambert, Hilde Lapeere, Tom Hillary, et al. 2024. “Did We Overreact? Insights on COVID-19 Disease and Vaccination in a Large Cohort of Immune-Mediated Inflammatory Disease Patients during Sequential Phases of the Pandemic (the BELCOMID Study).” VACCINES 12 (10). https://doi.org/10.3390/vaccines12101157.
- Chicago author-date (all authors)
- Geldof, Jeroen, Marie Truyens, João Sabino, Marc Ferrante, Jo Lambert, Hilde Lapeere, Tom Hillary, An Van Laethem, Kurt de Vlam, Patrick Verschueren, Triana Lobatón Ortega, Elizaveta Padalko, and Séverine Vermeire. 2024. “Did We Overreact? Insights on COVID-19 Disease and Vaccination in a Large Cohort of Immune-Mediated Inflammatory Disease Patients during Sequential Phases of the Pandemic (the BELCOMID Study).” VACCINES 12 (10). doi:10.3390/vaccines12101157.
- Vancouver
- 1.Geldof J, Truyens M, Sabino J, Ferrante M, Lambert J, Lapeere H, et al. Did we overreact? Insights on COVID-19 disease and vaccination in a large cohort of immune-mediated inflammatory disease patients during sequential phases of the pandemic (the BELCOMID study). VACCINES. 2024;12(10).
- IEEE
- [1]J. Geldof et al., “Did we overreact? Insights on COVID-19 disease and vaccination in a large cohort of immune-mediated inflammatory disease patients during sequential phases of the pandemic (the BELCOMID study),” VACCINES, vol. 12, no. 10, 2024.
@article{01JAZ232G9CT1AESHTHV99SFD7, abstract = {{Introduction: As the COVID-19 pandemic becomes an endemic state, still many questions remain regarding the risks and impact of SARS-CoV-2 infection and vaccination in patients with immune-mediated inflammatory diseases (IMIDs) who were excluded from the phase 3 COVID-19 vaccination trials. Methods: The BELCOMID study collected patient data and serological samples from a large, multicentric IMID patient cohort that was prospectively followed during sequential stages of the pandemic. Patients were stratified according to vaccination status into five groups across three sampling periods. Interactions between SARS-CoV-2 infection, COVID-19 vaccination status, IMID-treatment modalities and IMID course were explored. Results: In total, 2165 patients with IBD, a dermatological or rheumatological IMID participated. SARS-CoV-2 infection rates increased over the course of the pandemic and were highest in IMID patients that had refused every vaccine. After baseline COVID-19 vaccination, serologic spike (S)-antibody responses were attenuated by particular types of immune-modulating treatment: anti-TNF, rituximab, JAKi, systemic steroids, combined biologic/immunomodulator treatment. Nonetheless, S-antibody concentration increased progressively in patients who received a booster vaccination, reaching 100% seroconversion rate in patients who had received two booster vaccines. Previous SARS-CoV-2 infection was found as a predictor of higher S-antibody response. Patients who had refused every vaccine showed the lowest rates of S-seroconversion (53.8%). Multiple logistic regression did not identify previous SARS-CoV-2 infection as a risk factor for IMID flare-up. Furthermore, no increased risk of IMID flare-up was found with booster vaccination. Conclusions: Altogether, the BELCOMID study provides evidence for the efficacy and safety of COVID-19 vaccination and confirms the importance of repeated booster vaccination in IMID patients.}}, articleno = {{1157}}, author = {{Geldof, Jeroen and Truyens, Marie and Sabino, João and Ferrante, Marc and Lambert, Jo and Lapeere, Hilde and Hillary, Tom and Van Laethem, An and de Vlam, Kurt and Verschueren, Patrick and Lobatón Ortega, Triana and Padalko, Elizaveta and Vermeire, Séverine}}, issn = {{2076-393X}}, journal = {{VACCINES}}, language = {{eng}}, number = {{10}}, pages = {{24}}, title = {{Did we overreact? Insights on COVID-19 disease and vaccination in a large cohort of immune-mediated inflammatory disease patients during sequential phases of the pandemic (the BELCOMID study)}}, url = {{http://doi.org/10.3390/vaccines12101157}}, volume = {{12}}, year = {{2024}}, }
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