@article{01JAYS510ZMC6S3GBHX9GWDGN2,
  abstract     = {{Despite the excellent thermometric performance of many developed luminescent nanomaterials, their use
has not gone beyond proof-of-concept in vivo experiments to date. An important issue that needs to be
resolved before we can move towards true biomedical applications of engineered nanothermometers is
their potential toxicity and bioaccumulation in the human body considering the ultimate objective of
clinical applications. Since most reported nanothermometers currently are not degradable materials and
are mainly based on the incorporation of heavy metal ions, these aspects remain of genuine concern in
the fields of nanomedicine, nanobiotechnology, nanotoxicology, and nanopharmacology. In this work,
we explore the possibility of designing visible, as well as near-infrared, emitting luminescent ratiometric
nanothermometers based on appropriate organic dye mixtures embedded in hollow disulfide-bridged
periodic mesoporous organosilica (PMO) particles. Such hybrid particles show excellent thermometric
performance in the physiological temperature range (20-50 °C), favorable degradability in simulated
physiological conditions, as well as no toxicity to healthy normal human dermal fibroblast (NHDF) cells
in a wide concentration range. Considering the simplicity of the approach from the synthetic point of view,
and the large available library of known fluorescent dyes emitting in various regions of the
electromagnetic range, this motif renders a very promising approach to designing novel non-toxic,
decomposable, luminescent ratiometric thermometers.}},
  articleno    = {{2401026}},
  author       = {{Premcheska, Simona and Lederer, Mirijam and Mohanty, Sonali and Alici, Ayşe and Skirtach, Andre and Kaczmarek, Anna}},
  issn         = {{2195-1071}},
  journal      = {{ADVANCED OPTICAL MATERIALS}},
  keywords     = {{degradable materials,dyes,luminescence,periodic mesoporous organosilicas,ratiometric thermometry,METAL-ORGANIC FRAMEWORKS,SILICA NANOPARTICLES,TEMPERATURE,PROBE}},
  language     = {{eng}},
  number       = {{30}},
  pages        = {{13}},
  title        = {{Novel type of non-toxic, degradable, luminescent ratiometric thermometers based on dyes embedded in disulfide-bridged periodic mesoporous organosilica particles}},
  url          = {{http://doi.org/10.1002/adom.202401026}},
  volume       = {{12}},
  year         = {{2024}},
}

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